(Q38191881)

30 August 2017

title

The wonders of 2-deoxy-D-glucose (English)

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30 August 2017

Haibin Xi

1

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30 August 2017

Metin Kurtoglu

series ordinal

2

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30 August 2017

Theodore J Lampidis

series ordinal

3

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30 August 2017

publication date

27 February 2014

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30 August 2017

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30 August 2017

volume

66

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30 August 2017

issue

2

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30 August 2017

page(s)

110-121

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THE METABOLISM OF TUMORS IN THE BODY

30 August 2017

cites work

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Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation

21 January 2018

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Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells

21 January 2018

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2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

21 January 2018

1 reference

Sugar-free approaches to cancer cell killing

21 January 2018

1 reference

Hypersensitization of tumor cells to glycolytic inhibitors

21 January 2018

1 reference

Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).

21 January 2018

1 reference

From delocalized lipophilic cations to hypoxia: blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors

21 January 2018

1 reference

Hypoxia-regulated target genes implicated in tumor metastasis

21 January 2018

1 reference

Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.

21 January 2018

1 reference

Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas.

21 January 2018

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Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditions

21 January 2018

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2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

21 January 2018

1 reference

Targeting hypoxia, a novel treatment for advanced retinoblastoma

21 January 2018

1 reference

The inhibition of bovine heart hexokinase by 2-deoxy-D-glucose-6-phosphate: characterization by 31P NMR and metabolic implications

21 January 2018

1 reference

The effects of 2-deoxy-D-glucose on metabolism of slices of cerebral cortex incubated in vitro.

21 January 2018

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Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells".

21 January 2018

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Metabolism of 2-Deoxy-2-fluoro-d-[3H]glucose and 2-Deoxy-2-fluoro-d-[3H]mannose in Yeast and Chick-Embryo Cells

21 January 2018

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Interference with glycosylation of glycoproteins. Inhibition of formation of lipid-linked oligosaccharides in vivo

21 January 2018

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Formation of 2-Deoxyglucose-Containing Lipid-Linked Oligosaccharides. Interference with Glycosylation of Glycoproteins

21 January 2018

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2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma

21 January 2018

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2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines

21 January 2018

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Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia

21 January 2018

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

21 January 2018

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Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells

21 January 2018

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ER stress and the unfolded protein response

21 January 2018

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Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy

21 January 2018

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TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1.

21 January 2018

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Coping with stress: eIF2 kinases and translational control

21 January 2018

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2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer

21 January 2018

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13C and 31P NMR studies of glucose and 2-deoxyglucose metabolism in normal and enzyme-deficient human erythrocytes

21 January 2018

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Metabolic control of resistance of human epithelial cells to H2O2 and NO stresses

21 January 2018

1 reference

Autophagy in the Pathogenesis of Disease

21 January 2018

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Role of autophagy in cancer

21 January 2018

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Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy

21 January 2018

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Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy

21 January 2018

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Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

21 January 2018

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The engine driving the ship: metabolic steering of cell proliferation and death.

21 January 2018

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Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

21 January 2018

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Glucose-starved cells do not engage in prosurvival autophagy

21 January 2018

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Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.

21 January 2018

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

21 January 2018

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Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes

21 January 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

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Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

21 January 2018

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Energy dependence of autophagic protein degradation in isolated rat hepatocytes

21 January 2018

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Self-eating and self-killing: crosstalk between autophagy and apoptosis

21 January 2018

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A unique glucose-dependent apoptotic pathway induced by c-Myc

21 January 2018

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Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death

21 January 2018

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Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines

21 January 2018

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Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation.

21 January 2018

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BH3-only proteins trigger cytochrome c release, but how?

21 January 2018

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The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

21 January 2018

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The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose

21 January 2018

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Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice.

21 January 2018

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Bcl2 family proteins in carcinogenesis and the treatment of cancer.

21 January 2018

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Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation

21 January 2018

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Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy

21 January 2018

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ABT-263 enhances sensitivity to metformin and 2-deoxyglucose in pediatric glioma by promoting apoptotic cell death

21 January 2018

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Activation of the unfolded protein response by 2-deoxy-D-glucose inhibits Kaposi's sarcoma-associated herpesvirus replication and gene expression

21 January 2018

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Human cytomegalovirus infection activates and regulates the unfolded protein response

21 January 2018

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Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products

21 January 2018

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HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response

21 January 2018

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Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1

21 January 2018

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The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-

21 January 2018

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Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor.

21 January 2018

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Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells

21 January 2018

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Selective down-regulation of human papillomavirus transcription by 2-deoxyglucose

21 January 2018

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The global health burden of infection-associated cancers in the year 2002

21 January 2018

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21 January 2018

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Antiangiogenic activity of 2-deoxy-D-glucose

21 January 2018

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Role of PFKFB3-driven glycolysis in vessel sprouting

21 January 2018

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Glycolysis inhibition by 2-deoxy-D-glucose reverts the metastatic phenotype in vitro and in vivo.

21 January 2018

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Hypoxia-inducible factors, stem cells, and cancer

21 January 2018

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Tumor metastasis: molecular insights and evolving paradigms

21 January 2018

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Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response.

21 January 2018

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2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation.

21 January 2018

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A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors

21 January 2018

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Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

21 January 2018

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Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IUB.1251

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30 August 2017

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