(Q38198091)

30 August 2017

1 reference

title

Progesterone and its metabolites as therapeutic targets in psychiatric disorders (English)

1 reference

30 August 2017

Carolina Gubert

3

0 references

Adriane R Rosa

object named as

Adriane R Rosa

6

0 references

Flávio Kapczinski

5

object named as

Flávio Kapczinski

1 reference

30 August 2017

Giovana Bristot

1

1 reference

30 August 2017

Bruna Ascoli

2

1 reference

30 August 2017

Bruna Panizzutti

4

1 reference

30 August 2017

language of work or name

English

0 references

publication date

21 March 2014

1 reference

Expert Opinion on Therapeutic Targets

30 August 2017

1 reference

30 August 2017

18

1 reference

30 August 2017

6

1 reference

30 August 2017

679-690

1 reference

Neurosteroids: biochemistry and clinical significance

30 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

GABAergic neuroactive steroids: a new frontier in bipolar disorders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Dehydroepiandrosterone: biosynthesis and metabolism in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The regional brain distribution of the neurosteroids pregnenolone and pregnenolone sulfate following intravenous infusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone and progestins: effects on brain, allopregnanolone and beta-endorphin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neurosteroids and GABAA receptor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Pharmacology of endogenous neuroactive steroids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Subunit composition, distribution and function of GABA(A) receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Structure, pharmacology, and function of GABAA receptor subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Conserved site for neurosteroid modulation of GABA A receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Differential anesthetic activity of ketamine and the GABAergic neurosteroid allopregnanolone in mice lacking progesterone receptor A and B subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The steroid and thyroid hormone receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The neuropsychopharmacological potential of neuroactive steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The role of reproductive hormones in the development and maintenance of eating disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neuroprotective activity of a new class of steroidal inhibitors of the N-methyl-D-aspartate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Mechanism underlying potentiation by progesterone of the kainate-induced current in cultured neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Distinct effect of pregnenolone sulfate on NMDA receptor subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Molecular mechanism of pregnenolone sulfate action at NR1/NR2B receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Subtype-dependence of N-methyl-D-aspartate receptor modulation by pregnenolone sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neurosteroid-induced enhancement of glutamate transmission in rat hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Presynaptic modulation of synaptic transmission by pregnenolone sulfate as studied by optical recordings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Effects of steroids on NMDA receptors and excitatory synaptic transmission in neonatal motoneurons in rat spinal cord slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB [corrected] signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Src kinases: a hub for NMDA receptor regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Pregnenolone sulfate in the brain: a controversial neurosteroid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

20-oxo-5beta-pregnan-3alpha-yl sulfate is a use-dependent NMDA receptor inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone protects against lipid peroxidation following traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone and estrogen regulate oxidative metabolism in brain mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Estrogen enhances retrograde transport of brain-derived neurotrophic factor in the rodent forebrain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Mechanisms of estrogen action during neural development: mediation by interactions with the neurotrophins and their receptors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neurosteroids: endogenous role in the human brain and therapeutic potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neurosteroids: a novel function of the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Demonstration of progesterone receptors in rat Schwann cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone treatment normalizes the levels of cell proliferation and cell death in the dentate gyrus of the hippocampus after traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Slow-release and injected progesterone treatments enhance acute recovery after traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Estradiol and progesterone modify microtubule associated protein 2 content in the rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Beneficial immune activity after CNS injury: prospects for vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Post-ischemic administration of progesterone in rats exerts neuroprotective effects on the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone influences postischemic synaptogenesis in the CA1 region of the hippocampus in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Axonal growth-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Synaptophysin expression during synaptogenesis in the rat cerebellar cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Progesterone prevents depression-like behavior in a model of Parkinson's disease induced by 6-hydroxydopamine in male rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Effects of neurosteroids on glucocorticoid receptor-mediated gene transcription in LMCAT cells--a possible interaction with psychotropic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Fluoxetine decreases concentrations of 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) in major depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Plasma concentrations of neuroactive steroids before and after electroconvulsive therapy in major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

AKR1C4 gene variant associated with low euthymic serum progesterone and a history of mood irritability in males with bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neurosteroid secretion in panic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The clinical implications of cognitive impairment and allostatic load in bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Clinical implications of a staging model for bipolar disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

One-year psychosocial functioning in patients in the early vs. late stage of bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Peripheral biomarkers and illness activity in bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Is bipolar disorder an inflammatory condition? The relevance of microglial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Neuroimaging in bipolar disorder: what have we learned?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Allopregnanolone: state of the art.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

The role of allopregnanolone in depression and anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Translocator protein (18 kDa) (TSPO) as a therapeutic target for anxiety and neurologic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

An update on GABAA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.897329

10.1517/14728222.2014.897329

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference