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English
Sirtuin inhibitors as anticancer agents.
scientific article published on May 2014
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Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
title
Sirtuin inhibitors as anticancer agents
(English)
1 reference
stated in
Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
author
Hening Lin
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
author name string
Jing Hu
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
Hui Jing
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
publication date
1 May 2014
1 reference
stated in
Europe PubMed Central
PMCID
4384657
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
published in
Future Medicinal Chemistry
1 reference
stated in
Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
volume
6
1 reference
stated in
Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
issue
8
1 reference
stated in
Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
page(s)
945-966
1 reference
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Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
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6 September 2017
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
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6 September 2017
Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria
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6 September 2017
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
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6 September 2017
Mammalian sirtuins: biological insights and disease relevance
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6 September 2017
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
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6 September 2017
Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula
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6 September 2017
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
miR-34a repression of SIRT1 regulates apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Epigenetic control of rDNA loci in response to intracellular energy status
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
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6 September 2017
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Can we rationally design promiscuous drugs?
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
SIRT1 regulates HIV transcription via Tat deacetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Identification of a small molecule inhibitor of Sir2p
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Negative control of p53 by Sir2alpha promotes cell survival under stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
SIRT2 activity is required for the survival of C6 glioma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
6 September 2017
SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Function of the SIRT1 protein deacetylase in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
14 September 2017
SIRT6 exhibits nucleosome-dependent deacetylase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
23 June 2018
Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
23 June 2018
The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
23 June 2018
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
23 June 2018
Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
23 June 2018
Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
A fluorogenic assay for screening Sirt6 modulators
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
Substrate specificity of SIRT1-catalyzed lysine Nepsilon-deacetylation reaction probed with the side chain modified Nepsilon-acetyl-lysine analogs
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
Development and characterization of lysine based tripeptide analogues as inhibitors of Sir2 activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
Linking SIRT2 to Parkinson's disease.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
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31 August 2018
Chemical genetics: where genetics and pharmacology meet
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
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31 August 2018
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
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31 August 2018
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
31 August 2018
Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
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31 August 2018
Potent selective inhibitors of protein kinase C
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Crossref
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https://api.crossref.org/works/10.4155%2FFMC.14.44
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21 January 2018
Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)
2 references
stated in
Crossref
reference URL
https://api.crossref.org/works/10.4155%2FFMC.14.44
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21 January 2018
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384657
retrieved
3 December 2018
Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
1 reference
stated in
PubMed
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https://pubmed.ncbi.nlm.nih.gov/24962284
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24962284
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins
1 reference
stated in
PubMed
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https://pubmed.ncbi.nlm.nih.gov/24962284
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24962284
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24962284
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
N(epsilon)-methanesulfonyl-lysine as a non-hydrolyzable functional surrogate for N(epsilon)-acetyl-lysine
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24962284
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.4155/FMC.14.44
1 reference
stated in
Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PMCID
4384657
1 reference
stated in
Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PubMed ID
24962284
1 reference
stated in
Europe PubMed Central
PMCID
4384657
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24962284%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
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