(Q38233134)

31 August 2017

title

Molecular prognostic factors in glioblastoma: state of the art and future challenges (English)

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31 August 2017

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Ana Xavier-Magalhães

1

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Chris Jones

object named as

Chris Jones

series ordinal

3

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Bruno M. Costa

object named as

Bruno M Costa

series ordinal

4

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author name string

Meera Nandhabalan

series ordinal

2

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31 August 2017

publication date

1 November 2013

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31 August 2017

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31 August 2017

volume

2

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31 August 2017

issue

6

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31 August 2017

page(s)

495-510

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PI3Kinase signaling in glioblastoma

31 August 2017

cites work

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

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Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials

21 January 2018

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Prognostic factors for survival of patients with glioblastoma: recursive partitioning analysis

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Prognostic factors for survival in 676 consecutive patients with newly diagnosed primary glioblastoma

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Treatment outcome and prognostic factors of adult glioblastoma multiforme

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CD133/prominin1 is prognostic for GBM patient's survival, but inversely correlated with cysteine cathepsins' expression in glioblastoma derived spheroids

21 January 2018

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

21 January 2018

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NFKBIA deletion in glioblastomas

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The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas

21 January 2018

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Association between functional EGF+61 polymorphism and glioma risk.

21 January 2018

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Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma

21 January 2018

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Impact of EGFR genetic variants on glioma risk and patient outcome.

21 January 2018

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MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature

21 January 2018

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Biomarkers to predict response to epidermal growth factor receptor inhibitors

21 January 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

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YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas.

21 January 2018

1 reference

Prognostic significance of c-Met expression in glioblastomas

21 January 2018

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Sox11 expression in astrocytic gliomas: correlation with nestin/c-Met/IDH1-R132H expression phenotypes, p-Stat-3 and survival

21 January 2018

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

21 January 2018

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21 January 2018

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Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma

21 January 2018

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An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

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Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.

21 January 2018

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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

21 January 2018

1 reference

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

21 January 2018

1 reference

Molecular predictors in glioblastoma: toward personalized therapy

21 January 2018

1 reference

Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene

21 January 2018

1 reference

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

21 January 2018

1 reference

Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial

21 January 2018

1 reference

Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial

21 January 2018

1 reference

Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis.

21 January 2018

1 reference

MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.

21 January 2018

1 reference

Analysis of promoter CpG island hypermethylation in cancer: location, location, location!

21 January 2018

1 reference

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

21 January 2018

1 reference

Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM

21 January 2018

1 reference

IDH1 and IDH2 mutations in gliomas

21 January 2018

1 reference

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

1 reference

Analysis of the IDH1 codon 132 mutation in brain tumors

21 January 2018

1 reference

IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas

21 January 2018

1 reference

Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

21 January 2018

1 reference

Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

21 January 2018

1 reference

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

Cancer-associated IDH mutations: biomarker and therapeutic opportunities

21 January 2018

1 reference

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

1 reference

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

1 reference

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

1 reference

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

21 January 2018

1 reference

Histone demethylation by a family of JmjC domain-containing proteins

21 January 2018

1 reference

IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma

21 January 2018

1 reference

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

21 January 2018

1 reference

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

21 January 2018

1 reference

Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities

21 January 2018

1 reference

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

1 reference

21 January 2018

The microRNA Registry

1 reference

microRNAs as oncogenes and tumor suppressors

21 January 2018

1 reference

Oncomirs - microRNAs with a role in cancer

21 January 2018

1 reference

Gene expression and network-based analysis reveals a novel role for hsa-miR-9 and drug control over the p38 network in glioblastoma multiforme progression

21 January 2018

1 reference

Human glioma growth is controlled by microRNA-10b

21 January 2018

1 reference

MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme

21 January 2018

1 reference

miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion.

21 January 2018

1 reference

MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance

21 January 2018

1 reference

Upregulation of miR-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype

21 January 2018

1 reference

MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells

21 January 2018

1 reference

The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma

21 January 2018

1 reference

A ten-microRNA expression signature predicts survival in glioblastoma

21 January 2018

1 reference

Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme.

21 January 2018

1 reference

MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients

21 January 2018

1 reference

MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC.

21 January 2018

1 reference

MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10.

21 January 2018

1 reference

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

21 January 2018

1 reference

MiRNA-451 plays a role as tumor suppressor in human glioma cells

21 January 2018

1 reference

Definition of miRNAs expression profile in glioblastoma samples: the relevance of non-neoplastic brain reference.

21 January 2018

1 reference

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

21 January 2018

1 reference

Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients.

21 January 2018

1 reference

Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas.

21 January 2018

1 reference

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

21 January 2018

1 reference

The natural history of EGFR and EGFRvIII in glioblastoma patients

21 January 2018

1 reference

Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma

21 January 2018

1 reference

Amplification of the PDGFRA, KIT and KDR genes in glioblastoma: a population-based study.

21 January 2018

1 reference

Prevalence, clinico-pathological value, and co-occurrence of PDGFRA abnormalities in diffuse gliomas

21 January 2018

1 reference

Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme

21 January 2018

1 reference

Higher pAkt expression predicts a significant worse prognosis in glioblastomas

21 January 2018

1 reference

Homozygous 10q23/PTEN deletion and its impact on outcome in glioblastoma: a prospective translational study on a uniformly treated cohort of adult patients.

21 January 2018

1 reference

Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era.

21 January 2018

1 reference

Additive effect on survival of Raf kinase inhibitor protein and signal transducer and activator of transcription 3 in high-grade glioma

21 January 2018

1 reference

Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas

21 January 2018

1 reference

Malignant gliomas in adults

21 January 2018

1 reference

Response criteria for glioma

21 January 2018

1 reference

End point assessment in gliomas: novel treatments limit usefulness of classical Macdonald's Criteria

21 January 2018

1 reference

Cathepsin D is a potential serum marker for poor prognosis in glioma patients.

21 January 2018

1 reference

Serum alpha 2-HS glycoprotein predicts survival in patients with glioblastoma

21 January 2018

1 reference

Serum YKL-40 following resection for cerebral glioblastoma

21 January 2018

1 reference

Serum YKL-40 is a marker of prognosis and disease status in high-grade gliomas

21 January 2018

1 reference

YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma.

21 January 2018

1 reference

Plasma YKL-40: a potential new cancer biomarker?

21 January 2018

1 reference

Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

21 January 2018

1 reference

A distinct spectrum of copy number aberrations in pediatric high-grade gliomas

21 January 2018

1 reference

Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets

21 January 2018

1 reference

Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma

21 January 2018

1 reference

Paediatric and adult malignant glioma: close relatives or distant cousins?

21 January 2018

1 reference

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

1 reference

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

1 reference

Prognostic impact of CD133 mRNA expression in 48 glioblastoma patients treated with concomitant radiochemotherapy: a prospective patient cohort at a single institution.

21 January 2018

1 reference

Glioblastoma cancer stem-like cells: implications for pathogenesis and treatment

21 January 2018

1 reference

Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme.

21 January 2018

1 reference

Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis.

21 January 2018

1 reference

Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade.

21 January 2018

1 reference

Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network

21 January 2018

1 reference

Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas.

21 January 2018

1 reference

Analysis of mdm2 and p53 gene alterations in glioblastomas and its correlation with clinical factors.

21 January 2018

1 reference

Gene expression profiling and genetic markers in glioblastoma survival.

21 January 2018

1 reference

Clinical stratification of glioblastoma based on alterations in retinoblastoma tumor suppressor protein (RB1) and association with the proneural subtype

21 January 2018

1 reference

Impact of genotype and morphology on the prognosis of glioblastoma

21 January 2018

1 reference

Analysis of homozygous deletion of the p16 gene and correlation with survival in patients with glioblastoma multiforme

21 January 2018

1 reference

Cancer stem cells in nervous system tumors

21 January 2018

1 reference

Identification of human brain tumour initiating cells

21 January 2018

1 reference

Stem cell marker nestin and c-Jun NH2-terminal kinases in tumor and peritumor areas of glioblastoma multiforme: possible prognostic implications.

21 January 2018

1 reference

The prognostic value of nestin expression in newly diagnosed glioblastoma: report from the Radiation Therapy Oncology Group

21 January 2018

1 reference

The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas

21 January 2018

1 reference

Correlations between O6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study

21 January 2018

1 reference

The Hox genes and their roles in oncogenesis.

21 January 2018

1 reference

Differential expression of HOX genes in neoplastic and non-neoplastic human astrocytes

21 January 2018

1 reference

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

What is the clinical value of cancer stem cell markers in gliomas?

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

Current strategies for identification of glioma stem cells: adequate or unsatisfactory?

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

Clinical significance of molecular biomarkers in glioblastoma

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

Prognostic value of MGMT promoter methylation in glioblastoma patients treated with temozolomide-based chemoradiation: a Portuguese multicentre study.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

Short postoperative survival for glioblastoma patients with a dysfunctional Rb1 pathway in combination with no wild-type PTEN.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

The expression of PAX6, PTEN, vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: relationship to tumor grade and survival

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

Prognostic relevance of p53 protein expression in glioblastoma.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

Epidermal growth factor receptor gene amplification as a prognostic marker in glioblastoma multiforme: results of a meta-analysis

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6136097

TP53 gene mutations, nuclear p53 accumulation, expression of Waf/p21, Bcl-2, and CD95 (APO-1/Fas) proteins are not prognostic factors in de novo glioblastoma multiforme

5 November 2018

1 reference

12 December 2020

Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance

1 reference

12 December 2020

Sensitivity of metabolic fluxes to covalent control

1 reference

12 December 2020

World Health Organization classification of tumors

1 reference

12 December 2020

Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha

1 reference

12 December 2020

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene

1 reference

12 December 2020

Identifiers

DOI

10.2217/CNS.13.48

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31 August 2017

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