(Q38235868)

31 August 2017

Organelle-specific initiation of cell death (English)

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José Manuel Bravo-San Pedro

31 August 2017

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1

Lorenzo Galluzzi

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Guido Kroemer

series ordinal

3

object named as

Guido Kroemer

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object named as

José Manuel Bravo-San Pedro

series ordinal

2

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publication date

1 August 2014

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31 August 2017

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31 August 2017

16

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31 August 2017

8

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31 August 2017

728-736

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https://scigraph.springernature.com/pub.10.1038/ncb3005

31 August 2017

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cites work

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Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival

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Mitochondrial membrane permeabilization in cell death

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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p53 has a direct apoptogenic role at the mitochondria

21 January 2018

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p53 opens the mitochondrial permeability transition pore to trigger necrosis

21 January 2018

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Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

21 January 2018

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FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

21 January 2018

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A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

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Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

21 January 2018

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The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

21 January 2018

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Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

21 January 2018

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Caspase-2 activation in the absence of PIDDosome formation

21 January 2018

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Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway

21 January 2018

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PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

21 January 2018

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PARP inhibition: PARP1 and beyond

21 January 2018

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Cell death assays for drug discovery

21 January 2018

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Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

21 January 2018

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XIAP discriminates between type I and type II FAS-induced apoptosis

21 January 2018

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

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CD95 promotes tumour growth

21 January 2018

1 reference

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

21 January 2018

1 reference

TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

1 reference

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

21 January 2018

1 reference

The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase

21 January 2018

1 reference

The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex

21 January 2018

1 reference

Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity

21 January 2018

1 reference

Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage

21 January 2018

1 reference

TRPV1 receptors mediate particulate matter-induced apoptosis

21 January 2018

1 reference

Dampening of death pathways by schnurri-2 is essential for T-cell development

21 January 2018

1 reference

Apoptosis of uninfected cells induced by HIV envelope glycoproteins

21 January 2018

1 reference

Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation

21 January 2018

1 reference

A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism.

21 January 2018

1 reference

G protein-coupled receptors: novel targets for drug discovery in cancer

21 January 2018

1 reference

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis

21 January 2018

1 reference

Mitochondria: master regulators of danger signalling

21 January 2018

1 reference

Molecular ordering of hypoxia-induced apoptosis: critical involvement of the mitochondrial death pathway in a FADD/caspase-8 independent manner.

21 January 2018

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Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types

21 January 2018

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p53 regulates a non-apoptotic death induced by ROS.

21 January 2018

1 reference

The mitochondrial UPR - protecting organelle protein homeostasis

21 January 2018

1 reference

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

21 January 2018

1 reference

Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.

21 January 2018

1 reference

Endoplasmic reticulum-mitochondria contacts: function of the junction

21 January 2018

1 reference

Short RNA duplexes elicit RIG-I-mediated apoptosis in a cell type- and length-dependent manner.

21 January 2018

1 reference

A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis

21 January 2018

1 reference

MAVS-mediated apoptosis and its inhibition by viral proteins

21 January 2018

1 reference

Organization of the ER-Golgi interface for membrane traffic control

21 January 2018

1 reference

Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis

21 January 2018

1 reference

Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death

21 January 2018

1 reference

Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway

21 January 2018

1 reference

Crosstalk between ER stress and immunogenic cell death

21 January 2018

1 reference

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

21 January 2018

1 reference

PML regulates apoptosis at endoplasmic reticulum by modulating calcium release

21 January 2018

1 reference

ER stress triggers apoptosis by activating BH3-only protein Bim

21 January 2018

1 reference

Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1.

21 January 2018

1 reference

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

1 reference

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

21 January 2018

1 reference

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

21 January 2018

1 reference

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

21 January 2018

1 reference

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

21 January 2018

1 reference

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

21 January 2018

1 reference

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

21 January 2018

1 reference

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

21 January 2018

1 reference

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

21 January 2018

1 reference

The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis

21 January 2018

1 reference

The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress

21 January 2018

1 reference

CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model

21 January 2018

1 reference

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

21 January 2018

1 reference

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

1 reference

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

1 reference

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.

21 January 2018

1 reference

CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress

21 January 2018

1 reference

Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.

21 January 2018

1 reference

Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis

21 January 2018

1 reference

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

21 January 2018

1 reference

Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis

21 January 2018

1 reference

In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.

21 January 2018

1 reference

RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus

21 January 2018

1 reference

SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death.

21 January 2018

1 reference

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death

21 January 2018

1 reference

Lysosomal cell death at a glance.

21 January 2018

1 reference

Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine.

21 January 2018

1 reference

Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis.

21 January 2018

1 reference

Zinc and 4-hydroxy-2-nonenal mediate lysosomal membrane permeabilization induced by H2O2 in cultured hippocampal neurons.

21 January 2018

1 reference

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

21 January 2018

1 reference

The cathepsin B death pathway contributes to TNF plus IFN-gamma-mediated human endothelial injury

21 January 2018

1 reference

Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells.

21 January 2018

1 reference

Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia.

21 January 2018

1 reference

Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization

21 January 2018

1 reference

Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.

21 January 2018

1 reference

Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion

21 January 2018

1 reference

Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells

21 January 2018

1 reference

Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

21 January 2018

1 reference

Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues

21 January 2018

1 reference

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

21 January 2018

1 reference

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

21 January 2018

1 reference

Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis

21 January 2018

1 reference

Intralysosomal iron chelation protects against oxidative stress-induced cellular damage.

21 January 2018

1 reference

Ferroptosis: an iron-dependent form of nonapoptotic cell death

21 January 2018

1 reference

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

21 January 2018

1 reference

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

21 January 2018

1 reference

Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates

21 January 2018

1 reference

Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death

21 January 2018

1 reference

An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury

21 January 2018

1 reference

Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.

21 January 2018

1 reference

Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.

21 January 2018

1 reference

Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation

21 January 2018

1 reference

Mitochondrial membrane permeabilization in neuronal injury

21 January 2018

1 reference

Stat3 controls lysosomal-mediated cell death in vivo.

21 January 2018

1 reference

Many cuts to ruin: a comprehensive update of caspase substrates

21 January 2018

1 reference

Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events

21 January 2018

1 reference

Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients

21 January 2018

1 reference

Microtubule-targeted agents: when mitochondria become essential to chemotherapy

21 January 2018

1 reference

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

21 January 2018

1 reference

Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim.

21 January 2018

1 reference

Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis

21 January 2018

1 reference

Filamin A protects cells against force-induced apoptosis by stabilizing talin- and vinculin-containing cell adhesions

21 January 2018

1 reference

Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors

21 January 2018

1 reference

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

21 January 2018

1 reference

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

1 reference

Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanoma.

21 January 2018

1 reference

Ezrin is a negative regulator of death receptor-induced apoptosis

21 January 2018

1 reference

Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the Bcl-2 homology domain 3-only protein Bim.

21 January 2018

1 reference

Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation.

21 January 2018

1 reference

Mitochondrial translocation of cofilin is an early step in apoptosis induction.

21 January 2018

1 reference

Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin

21 January 2018

1 reference

Mitochondrial translocation of oxidized cofilin induces caspase-independent necrotic-like programmed cell death of T cells

21 January 2018

1 reference

Organelle-specific initiation of cell death pathways

21 January 2018

1 reference

The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development

21 January 2018

1 reference

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

21 January 2018

1 reference

TLR9 agonists induced cell death in Burkitt's lymphoma cells is variable and influenced by TLR9 polymorphism

21 January 2018

1 reference

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

21 January 2018

1 reference

A Complex between Atg7 and Caspase-9: A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS.

21 January 2018

1 reference

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

21 January 2018

1 reference

Apoptosis: controlled demolition at the cellular level

21 January 2018

1 reference

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

21 January 2018

1 reference

12 December 2020

Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels.

1 reference

12 December 2020

Protection against oxidant-mediated lysosomal rupture: a new anti-apoptotic activity of Bcl-2?

1 reference

12 December 2020

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

1 reference

12 December 2020

Dependence receptors: from basic research to drug development

1 reference

12 December 2020

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

1 reference

12 December 2020

Mechanism of toxicity in rotenone models of Parkinson's disease

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCB3005

1 reference

PubMed ID

25082195

Dimensions Publication ID

31 August 2017

0 references

1 reference

PubMed ID

25082195