(Q37526353)

20 August 2017

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title

Mitochondrial membrane permeabilization in neuronal injury (English)

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20 August 2017

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1

Lorenzo Galluzzi

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Guido Kroemer

series ordinal

3

object named as

Guido Kroemer

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Klas Blomgren

object named as

Klas Blomgren

series ordinal

2

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language of work or name

English

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publication date

1 July 2009

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Nature Reviews Neuroscience

20 August 2017

published in

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20 August 2017

volume

10

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20 August 2017

issue

7

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20 August 2017

page(s)

481-494

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Astrocyte metabolism and signaling during brain ischemia

20 August 2017

cites work

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Mitochondrial membrane permeabilization in cell death

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Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons

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SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia.

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ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury

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Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects

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Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia

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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

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Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation

31 March 2020

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Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis

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Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model

31 March 2020

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Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion

31 March 2020

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Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury

31 March 2020

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Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway

31 March 2020

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Neuroprotection against ischemic brain injury by a small peptide inhibitor of c-Jun N-terminal kinase (JNK) via nuclear and non-nuclear pathways

31 March 2020

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Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury.

31 March 2020

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A critical role of neural-specific JNK3 for ischemic apoptosis

31 March 2020

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Specific pathophysiological functions of JNK isoforms in the brain

31 March 2020

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Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric oxide in human glioblastoma cells

31 March 2020

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JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

31 March 2020

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Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.

31 March 2020

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Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS.

31 March 2020

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PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury

31 March 2020

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Phosphorylation of PTEN and Akt in astrocytes of the rat hippocampus following transient forebrain ischemia

31 March 2020

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Nitric oxide, cell bioenergetics and neurodegeneration.

31 March 2020

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Mitochondria as targets of apoptosis regulation by nitric oxide

31 March 2020

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Increased neurons containing neuronal nitric oxide synthase in the brain of a hypoxic-ischemic neonatal rat model

31 March 2020

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HIF-1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion.

31 March 2020

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The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

31 March 2020

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Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia

31 March 2020

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S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury

31 March 2020

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Nitric oxide is involved in ischemia-induced apoptosis in brain: a study in neuronal nitric oxide synthase null mice

31 March 2020

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Gene-dosing effect and persistence of reduction in ischemic brain injury in mice lacking inducible nitric oxide synthase

31 March 2020

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The nitric oxide donor LA 419 decreases brain damage in a focal ischemia model

31 March 2020

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Exogenous nitric oxide negatively regulates c-Jun N-terminal kinase activation via inhibiting endogenous NO-induced S-nitrosylation during cerebral ischemia and reperfusion in rat hippocampus

31 March 2020

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Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke

31 March 2020

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Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus.

31 March 2020

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Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia

31 March 2020

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Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase

31 March 2020

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Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals

31 March 2020

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Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury

31 March 2020

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Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.

31 March 2020

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Glutathione peroxidase inhibits cell death and glial activation following experimental stroke

31 March 2020

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Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

31 March 2020

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Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1.

31 March 2020

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Overexpression of SOD1 in transgenic rats attenuates nuclear translocation of endonuclease G and apoptosis after spinal cord injury

31 March 2020

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Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging

31 March 2020

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The novel antioxidant edaravone: from bench to bedside

31 March 2020

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Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis

31 March 2020

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Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity.

31 March 2020

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Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice

31 March 2020

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Intravenous TAT-Bcl-Xl is protective after middle cerebral artery occlusion in mice

31 March 2020

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Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain

31 March 2020

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BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

31 March 2020

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BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways

31 March 2020

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Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury.

31 March 2020

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Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats

31 March 2020

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Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.

31 March 2020

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BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

31 March 2020

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Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia

31 March 2020

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

31 March 2020

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Necroptosis: a specialized pathway of programmed necrosis

31 March 2020

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Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion

31 March 2020

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

31 March 2020

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Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

31 March 2020

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Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury

31 March 2020

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All three isoforms of the voltage-dependent anion channel (VDAC1, VDAC2, and VDAC3) are present in mitochondria from bovine, rabbit, and rat brain

31 March 2020

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Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death

31 March 2020

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

31 March 2020

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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

31 March 2020

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DNA methylation is required for silencing of ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells

31 March 2020

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Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor

31 March 2020

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Hexokinase binding in ischemic and reperfused piglet brain

31 March 2020

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Glycolysis and perinatal hypoxic-ischemic brain damage

31 March 2020

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Regulation of hexokinase binding to VDAC

31 March 2020

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Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.

31 March 2020

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Mitochondrial creatine kinase in human health and disease

31 March 2020

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Protective effects of oral creatine supplementation on spinal cord injury in rats.

31 March 2020

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Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration

31 March 2020

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Oxidative phosphorylation at the fin de siècle

31 March 2020

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Blockade of electron transport during ischemia protects cardiac mitochondria

31 March 2020

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Respiratory chain inhibition induces tolerance to focal cerebral ischemia

31 March 2020

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Mitochondrial uncoupling proteins in the CNS: in support of function and survival.

31 March 2020

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Amplified expression of uncoupling proteins in human brain ischemic lesions

31 March 2020

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Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

31 March 2020

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Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels

31 March 2020

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The transcriptional targets of p53 in apoptosis control

31 March 2020

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Transcription-independent pro-apoptotic functions of p53.

31 March 2020

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Targeting p53 to mitochondria for cancer therapy

31 March 2020

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Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats.

31 March 2020

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Enhanced expression of p53 in reactive astrocytes following transient focal ischemia

31 March 2020

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A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

31 March 2020

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The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha

31 March 2020

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p53 potentiates hippocampal neuronal death caused by global ischemia

31 March 2020

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Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

31 March 2020

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Regulation of autophagy by cytoplasmic p53

31 March 2020

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Potential therapeutic applications of autophagy

31 March 2020

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Aggravation of brain injury after transient focal ischemia in p53-deficient mice

31 March 2020

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p53 regulates mitochondrial respiration

31 March 2020

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The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia.

31 March 2020

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Mechanisms of cytochrome c release from mitochondria

31 March 2020

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Targeting post-mitochondrial effectors of apoptosis for neuroprotection

31 March 2020

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Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

31 March 2020

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Proteome-wide Identification of HtrA2/Omi Substrates

31 March 2020

1 reference

No death without life: vital functions of apoptotic effectors

31 March 2020

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Caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia

31 March 2020

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Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia

31 March 2020

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Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo

31 March 2020

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

31 March 2020

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Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice.

31 March 2020

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Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation

31 March 2020

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Caspase-3 deficiency during development increases vulnerability to hypoxic-ischemic injury through caspase-3-independent pathways

31 March 2020

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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

31 March 2020

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Apaf1 is required for mitochondrial pathways of apoptosis and brain development

31 March 2020

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Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

31 March 2020

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Inhibition of apoptosome activation protects injured motor neurons from cell death

31 March 2020

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Apaf-1 deficiency and neural tube closure defects are found in fog mice

31 March 2020

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Nonapoptotic role for Apaf-1 in the DNA damage checkpoint

31 March 2020

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A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint

31 March 2020

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boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats

31 March 2020

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Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury

31 March 2020

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Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury

31 March 2020

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Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

31 March 2020

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Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.

31 March 2020

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Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain

31 March 2020

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X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia

31 March 2020

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Oxidative stress is associated with XIAP and Smac/DIABLO signaling pathways in mouse brains after transient focal cerebral ischemia

31 March 2020

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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

31 March 2020

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Generation and characterization of Smac/DIABLO-deficient mice.

31 March 2020

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The X-linked inhibitor of apoptosis (XIAP) prevents cell death in axotomized CNS neurons in vivo.

31 March 2020

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Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

31 March 2020

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IAP family proteins delay motoneuron cell death in vivo

31 March 2020

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Apoptosis inhibition in ischemic brain by intraperitoneal PTD-BIR3-RING (XIAP).

31 March 2020

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Monoubiquitination and cellular distribution of XIAP in neurons after traumatic brain injury

31 March 2020

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Targeted expression of anti-apoptotic protein p35 in oligodendrocytes reduces delayed demyelination and functional impairment after spinal cord injury

31 March 2020

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AIF deficiency compromises oxidative phosphorylation

31 March 2020

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Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

31 March 2020

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The harlequin mouse mutation downregulates apoptosis-inducing factor

31 March 2020

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Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.

31 March 2020

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Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms

31 March 2020

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Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury

31 March 2020

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Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia

31 March 2020

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EndoG is dispensable in embryogenesis and apoptosis

31 March 2020

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Role of EndoG in development and cell injury

31 March 2020

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Early nuclear translocation of endonuclease G and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.

31 March 2020

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Focal cerebral ischaemia increases the levels of several classes of heat shock proteins and their corresponding mRNAs.

31 March 2020

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Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.

31 March 2020

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Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro

31 March 2020

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Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection

31 March 2020

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Negative regulation of the Apaf-1 apoptosome by Hsp70

31 March 2020

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Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation

31 March 2020

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Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.

31 March 2020

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Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP

31 March 2020

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Neuroprotective effects of virally delivered HSPs in experimental stroke

31 March 2020

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Changes in immunoreactivity of HSP60 and its neuroprotective effects in the gerbil hippocampal CA1 region induced by transient ischemia

31 March 2020

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Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70

31 March 2020

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Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2.

31 March 2020

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Effects of hsp70.1 gene knockout on the mitochondrial apoptotic pathway after focal cerebral ischemia.

31 March 2020

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Caspase 3 activation is essential for neuroprotection in preconditioning

31 March 2020

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Structure, activation, and biology of calpain

31 March 2020

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Mechanistic role of calpains in postischemic neurodegeneration

31 March 2020

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Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"?

31 March 2020

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Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.

31 March 2020

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Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.

31 March 2020

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The plasma membrane Na+/Ca2+ exchanger is cleaved by distinct protease families in neuronal cell death

31 March 2020

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Ischemic neuronal death in the rat hippocampus: the calpain-calpastatin-caspase hypothesis

31 March 2020

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Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia

31 March 2020

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Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'.

31 March 2020

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Ca2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates

31 March 2020

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Activation of calpain, cathepsin-b and caspase-3 during transient focal cerebral ischemia in rat model

31 March 2020

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN2665

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20 August 2017

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