(Q38248803)

1 September 2017

1 reference

title

Senescent cells: SASPected drivers of age-related pathologies (English)

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1 September 2017

1

Yossi Ovadya

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1 September 2017

Valery Krizhanovsky

2

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1 September 2017

13 September 2014

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1 September 2017

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1 September 2017

15

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1 September 2017

6

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1 September 2017

627-642

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https://scigraph.springernature.com/pub.10.1007/s10522-014-9529-9

1 September 2017

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cites work

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Chemokine signaling via the CXCR2 receptor reinforces senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Inflammation and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Cataract and surgery for cataract

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Astrocyte senescence as a component of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

T-helper-1-cell cytokines drive cancer into senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Microarray analysis of senescent vascular smooth muscle cells: A link to atherosclerosis and vascular calcification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Cellular senescence: when bad things happen to good cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Aging, cellular senescence, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Tumour biology: senescence in premalignant tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Important Causes of Visual Impairment in the World Today

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

21 January 2018

The adversities of aging

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Rapamycin decelerates cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

A DNA damage checkpoint response in telomere-initiated senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Type 2 diabetes as an inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Cellular senescence in vivo: its relevance in ageing and cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Short telomeres limit tumor progression in vivo by inducing senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

A DNA methylation fingerprint of 1628 human samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Modulating human aging and age-associated diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Inflammatory networks during cellular senescence: causes and consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Lamin B1 loss is a senescence-associated biomarker.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Development of monocytes, macrophages, and dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Osteoporosis, inflammation and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Mechanisms underlying inflammation in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Vascular smooth muscle cell senescence in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Understanding immunosenescence to improve responses to vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

NKG2D and cytotoxic effector function in tumor immune surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

The impact of ageing on natural killer cell function and potential consequences for health in older adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

How genetic analysis tests theories of animal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Cellular senescence in aging primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

DNA Damage, Aging, and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Mechanistic links between COPD and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Immune surveillance of unhealthy cells by natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Microenvironmental regulation of metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

The sirtuin SIRT6 regulates lifespan in male mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Genomic DNA methylation: the mark and its mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

21 January 2018

Chasing the cancer demon

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Chromatin modifications and their function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Ink4a/Arf expression is a biomarker of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Senescence of activated stellate cells limits liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Glucocorticoids suppress selected components of the senescence-associated secretory phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

T cell senescence and contraction of T cell repertoire diversity in patients with chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Epigenetic Control of MicroRNA Expression and Aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Inflammation in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

21 January 2018

The hallmarks of aging

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Non-cell-autonomous tumor suppression by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Widespread and tissue specific age-related DNA methylation changes in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Macrophage plasticity and polarization in tissue repair and remodelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

HMGA2 expression in white adipose tissue linking cellular senescence with diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Vascular cell senescence: contribution to atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

The role of DNA damage and repair in aging through the prism of Koch-like criteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Protective and pathogenic functions of macrophage subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Inflammation in atherosclerosis and implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Microglia in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Macrophage diversity enhances tumor progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Aging is not a disease: implications for intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Osteoporosis: a still increasing prevalence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Type 2 diabetes-a matter of beta-cell life and death?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Immunosurveillance of senescent cells: the bright side of the senescence program

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Granule exocytosis mediates immune surveillance of senescent cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Cellular senescence and its effector programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Inflammation in Alzheimer's disease: insights from immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Role of oxidatively induced DNA lesions in human pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Age-dependent dysregulation of innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

The role of nuclear lamin B1 in cell proliferation and senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Nonenzymatic posttranslational protein modifications in ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Molecular links between cellular senescence, longevity and age-related diseases - a systems biology perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

DNA damage foci at dysfunctional telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Mechanistic links between aging and lung fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

p53 mutant mice that display early ageing-associated phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Recent advances in pre-clinical mouse models of COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Oxidative stress shortens telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

Telomerized presenescent osteoblasts prevent bone mass loss in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-014-9529-9

10.1007/S10522-014-9529-9

21 January 2018

Identifiers

DOI

1 reference

PubMed ID

25217383

Dimensions Publication ID

1 September 2017

0 references

1 reference

PubMed ID

25217383