(Q38275382)

1 September 2017

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title

Kinases, tails and more: regulation of PTEN function by phosphorylation (English)

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1 September 2017

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Rita Fragoso

1

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João T. Barata

object named as

João T Barata

series ordinal

2

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language of work or name

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22 October 2014

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1 September 2017

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1 September 2017

volume

77-78

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1 September 2017

page(s)

75-81

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 September 2017

cites work

1 reference

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Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

7 January 2021

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The biology and clinical relevance of the PTEN tumor suppressor pathway

7 January 2021

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

7 January 2021

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Pten is essential for embryonic development and tumour suppression

7 January 2021

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

7 January 2021

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

7 January 2021

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Subtle variations in Pten dose determine cancer susceptibility

7 January 2021

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A continuum model for tumour suppression

7 January 2021

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The multiple layers of non-genetic regulation of PTEN tumour suppressor activity

7 January 2021

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Tenets of PTEN tumor suppression

7 January 2021

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Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma

7 January 2021

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7 January 2021

New insights into PTEN.

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

7 January 2021

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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

7 January 2021

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PTEN and the PI3-kinase pathway in cancer

7 January 2021

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7 January 2021

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A unified nomenclature and amino acid numbering for human PTEN.

7 January 2021

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Phosphorylation of the PTEN tail regulates protein stability and function

7 January 2021

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The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

7 January 2021

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Direct identification of PTEN phosphorylation sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

7 January 2021

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Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain

7 January 2021

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Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane

7 January 2021

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Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

7 January 2021

1 reference

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Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase

7 January 2021

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p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.

7 January 2021

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Membrane-binding and activation mechanism of PTEN.

7 January 2021

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Phosphorylation keeps PTEN phosphatase closed for business

7 January 2021

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A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

7 January 2021

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Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

7 January 2021

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Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs

7 January 2021

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Regulation of PTEN by Rho small GTPases

7 January 2021

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Rak functions as a tumor suppressor by regulating PTEN protein stability and function

7 January 2021

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Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity

7 January 2021

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Deubiquitylation and stabilization of PTEN by USP13

7 January 2021

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Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions

7 January 2021

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Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3beta and stimulate axonal growth

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

7 January 2021

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Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

PTEN is destabilized by phosphorylation on Thr366.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Regulation of PTEN stability and activity by Plk3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2014.10.015

10.1016/J.YMETH.2014.10.015

7 January 2021

Identifiers

DOI

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1 September 2017

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