(Q38287226)

1 September 2017

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title

The molecular mechanisms underlying the therapeutic resistance of cancer stem cells (English)

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1 September 2017

main subject

neoplastic stem cells

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Jun-Kyum Kim

1

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1 September 2017

Hee-Young Jeon

series ordinal

2

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1 September 2017

Hyunggee Kim

series ordinal

3

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1 September 2017

publication date

13 December 2014

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Archives of Pharmacal Research

1 September 2017

published in

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1 September 2017

volume

38

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1 September 2017

issue

3

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1 September 2017

page(s)

389-401

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Mechanisms of chemoresistance in cancer stem cells

1 September 2017

cites work

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Multiple myeloma: a paradigm for translation of the cancer stem cell hypothesis

21 January 2018

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Cancer stem cells in solid tumors

21 January 2018

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

21 January 2018

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Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

21 January 2018

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Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy.

21 January 2018

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DNA-damage response in tissue-specific and cancer stem cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

21 January 2018

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Cancer stem cell niche: the place to be

21 January 2018

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Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma

21 January 2018

1 reference

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The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance

21 January 2018

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The CDK inhibitors: potential targets for therapeutic stem cell manipulations?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Orthotopic glioblastoma stem-like cell xenograft model in mice to evaluate intra-arterial delivery of bevacizumab: from bedside to bench

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

The cancer stem cell niche--there goes the neighborhood?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

A perivascular niche for brain tumor stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/β-catenin-ATP-binding cassette G2 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

CD95 promotes tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

ATR: an essential regulator of genome integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Cancer stem cells: implications for the progression and treatment of metastatic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

New insights into checkpoint kinase 1 in the DNA damage response signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

CD133+ cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Stem cell concepts renew cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Association of reactive oxygen species levels and radioresistance in cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

ABC transporters in cancer: more than just drug efflux pumps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Regulation of apoptosis pathways in cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Apoptosis signaling in cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

The critical role of SDF-1/CXCR4 axis in cancer and cancer stem cells metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

The cancer stem cell microenvironment and anti-cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Polycomb group proteins in the DNA damage response: a link between radiation resistance and "stemness".

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

γ-Secretase Inhibitors Enhance Temozolomide Treatment of Human Gliomas by Inhibiting Neurosphere Repopulation and Xenograft Recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

DNA damage-mediated induction of a chemoresistant niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

CD13 is a therapeutic target in human liver cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Cancer drug resistance: an evolving paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Hedgehog pathway activation in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Radiation-induced Notch signaling in breast cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Radiation-induced reprogramming of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

TNFα enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Getting TRAIL back on track for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

NOTCH1 signaling promotes chemoresistance via regulating ABCC1 expression in prostate cancer stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Phase I and pharmacokinetic study of lapatinib and docetaxel in patients with advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Intrinsic tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Cancer stem cells: impact, heterogeneity, and uncertainty

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Radioresistance of glioma stem cells: intrinsic characteristic or property of the 'microenvironment-stem cell unit'?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

DNA damage repair pathways in cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Quiescent, slow-cycling stem cell populations in cancer: a review of the evidence and discussion of significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Drug review: Safety and efficacy of bevacizumab for glioblastoma and other brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Cancer stem cells and self-renewal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Role of cell cycle in mediating sensitivity to radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Notch signalling in solid tumours: a little bit of everything but not all the time

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

A drug from poison: how the therapeutic effect of arsenic trioxide on acute promyelocytic leukemia was discovered

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

TNF-induced signaling in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Stem cells, cancer, and cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Cancer stem cells in radiation resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

IAP proteins: blocking the road to death's door

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Identification and targeting of cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Identification of cells initiating human melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Identification of a specific inhibitor of the dishevelled PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Reactive oxygen species in cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

ATM and ATR: networking cellular responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Understanding cancer stem cell heterogeneity and plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

CXCR4 as biomarker for radioresistant cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Comparative proteomics of colon cancer stem cells and differentiated tumor cells identifies BIRC6 as a potential therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Wnt pathway activity confers chemoresistance to cancer stem-like cells in a neuroblastoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Regulation of self-renewal in normal and cancer stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

The emerging role of Polycomb repressors in the response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Caveolin-1 mediates chemoresistance in breast cancer stem cells via β-catenin/ABCG2 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

The phenotypic radiation resistance of CD44+/CD24(-or low) breast cancer cells is mediated through the enhanced activation of ATM signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-014-0531-1

10.1007/S12272-014-0531-1

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

1 September 2017

1018982949

0 references

1 reference