(Q38530635)

3 September 2017

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title

Cloaked in ubiquitin, a killer hides in plain sight: the molecular regulation of RIPK1. (English)

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3 September 2017

Scott J Justus

1

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3 September 2017

Adrian T Ting

series ordinal

2

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3 September 2017

publication date

1 July 2015

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3 September 2017

published in

Immunological Reviews

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3 September 2017

volume

266

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3 September 2017

issue

1

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3 September 2017

page(s)

145-160

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Cell death mechanisms and the immune system

3 September 2017

cites work

1 reference

21 January 2018

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Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies

21 January 2018

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Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules

21 January 2018

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Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

21 January 2018

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Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

21 January 2018

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A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

21 January 2018

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RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

21 January 2018

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

21 January 2018

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FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

21 January 2018

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A novel domain within the 55 kd TNF receptor signals cell death

21 January 2018

1 reference

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

21 January 2018

1 reference

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

21 January 2018

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The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

21 January 2018

1 reference

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

21 January 2018

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

21 January 2018

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

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The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death

21 January 2018

1 reference

Regulated commitment of TNF receptor signaling: a molecular switch for death or activation.

21 January 2018

1 reference

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

21 January 2018

1 reference

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

1 reference

FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

21 January 2018

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Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

21 January 2018

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Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

21 January 2018

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FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

21 January 2018

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Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

21 January 2018

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The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

21 January 2018

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

1 reference

Inhibition of death receptor signals by cellular FLIP

21 January 2018

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NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

21 January 2018

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NF-kappaB signals induce the expression of c-FLIP.

21 January 2018

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Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

21 January 2018

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Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

21 January 2018

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Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro

21 January 2018

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

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Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

21 January 2018

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A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

21 January 2018

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Linear ubiquitination prevents inflammation and regulates immune signalling

21 January 2018

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

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Ubiquitin signalling in the NF-kappaB pathway

21 January 2018

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

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Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

21 January 2018

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Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

21 January 2018

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Chronicles of a death foretold: dual sequential cell death checkpoints in TNF signaling

21 January 2018

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Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1

21 January 2018

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The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

21 January 2018

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Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

21 January 2018

1 reference

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

21 January 2018

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

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Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

21 January 2018

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Synthetic Smac peptide enhances the effect of etoposide-induced apoptosis in human glioblastoma cell lines

21 January 2018

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A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

21 January 2018

1 reference

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

21 January 2018

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

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The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases

21 January 2018

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

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Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

21 January 2018

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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

21 January 2018

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TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

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Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

21 January 2018

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A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses

21 January 2018

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Caspase 8 inhibits programmed necrosis by processing CYLD

21 January 2018

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

21 January 2018

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

21 January 2018

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Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

21 January 2018

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Resistance to the cytotoxic effects of tumor necrosis factor alpha can be overcome by inhibition of a FADD/caspase-dependent signaling pathway

21 January 2018

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Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cells

21 January 2018

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Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

21 January 2018

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Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2.

21 January 2018

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A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

21 January 2018

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TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

21 January 2018

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Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

21 January 2018

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Identification of RIP1 kinase as a specific cellular target of necrostatins

21 January 2018

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

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Molecular mechanisms and pathophysiology of necrotic cell death

21 January 2018

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Cell death by necrosis, a regulated way to go.

21 January 2018

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TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death

21 January 2018

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

21 January 2018

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

21 January 2018

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Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.

21 January 2018

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The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

21 January 2018

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The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

21 January 2018

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The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

21 January 2018

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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

21 January 2018

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Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

21 January 2018

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

21 January 2018

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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

21 January 2018

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Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

21 January 2018

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MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

21 January 2018

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Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

21 January 2018

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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

21 January 2018

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Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

21 January 2018

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Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart

21 January 2018

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Caspase-8 serves both apoptotic and nonapoptotic roles

21 January 2018

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Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

21 January 2018

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Mechanisms of necroptosis in T cells

21 January 2018

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Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

21 January 2018

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Dynamic expression of epidermal caspase 8 simulates a wound healing response

21 January 2018

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Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice

21 January 2018

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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

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Functional complementation between FADD and RIP1 in embryos and lymphocytes

21 January 2018

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

21 January 2018

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Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

21 January 2018

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Survival function of the FADD-CASPASE-8-cFLIP(L) complex

21 January 2018

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FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

21 January 2018

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Protective roles for caspase-8 and cFLIP in adult homeostasis.

21 January 2018

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Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation

21 January 2018

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Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain.

21 January 2018

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Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

21 January 2018

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NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling

21 January 2018

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Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins

21 January 2018

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NEMO inhibits programmed necrosis in an NFκB-independent manner by restraining RIP1.

21 January 2018

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TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP.

21 January 2018

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TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity

21 January 2018

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cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

21 January 2018

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The prevalence of TNFα-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay

21 January 2018

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Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation

21 January 2018

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

21 January 2018

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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

21 January 2018

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Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.

21 January 2018

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A ubiquitin ligase complex assembles linear polyubiquitin chains

21 January 2018

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Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

21 January 2018

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TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

21 January 2018

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Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

21 January 2018

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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

21 January 2018

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

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Direct activation of protein kinases by unanchored polyubiquitin chains

21 January 2018

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Pan-caspase inhibitor zVAD enhances cell death in RAW246.7 macrophages

21 January 2018

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Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death

21 January 2018

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Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen-activated protein kinase/STAT1/reactive oxygen species pathway

21 January 2018

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Autophagy contributes to caspase-independent macrophage cell death

21 January 2018

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NF-kappaB protects macrophages from lipopolysaccharide-induced cell death: the role of caspase 8 and receptor-interacting protein

21 January 2018

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Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

21 January 2018

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RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

21 January 2018

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Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia.

21 January 2018

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Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways

21 January 2018

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Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

21 January 2018

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dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8.

21 January 2018

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Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.

21 January 2018

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Virus inhibition of RIP3-dependent necrosis

21 January 2018

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DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

21 January 2018

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TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

21 January 2018

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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation

21 January 2018

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TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

21 January 2018

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RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

21 January 2018

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RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

21 January 2018

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RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

21 January 2018

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RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

21 January 2018

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RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

21 January 2018

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Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

21 January 2018

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RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.

21 January 2018

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RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis

21 January 2018

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RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

21 January 2018

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Two distinct signalling cascades target the NF-kappaB regulatory factor c-IAP1 for degradation

21 January 2018

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Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1).

21 January 2018

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Regulation of TRAF2 signaling by self-induced degradation.

21 January 2018

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TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

21 January 2018

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TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8

21 January 2018

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Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

21 January 2018

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Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

21 January 2018

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Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.

21 January 2018

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Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

21 January 2018

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RIP3 induces apoptosis independent of pronecrotic kinase activity

21 January 2018

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Viral modulation of the host response via crmA/SPI-2 expression.

21 January 2018

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Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

21 January 2018

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Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis

21 January 2018

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Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade

21 January 2018

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Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling

21 January 2018

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Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-κB essential modulator

21 January 2018

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Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon

21 January 2018

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A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response

21 January 2018

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The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response

21 January 2018

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Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

21 January 2018

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The E. coli effector protein NleF is a caspase inhibitor

21 January 2018

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TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.

21 January 2018

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Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

21 January 2018

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Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability.

21 January 2018

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p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils

21 January 2018

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Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression

21 January 2018

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Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis

21 January 2018

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Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.

21 January 2018

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The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation

21 January 2018

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Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12304

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3 September 2017

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