(Q38606426)

4 September 2017

Natural and Synthetic Flavonoids: Structure-Activity Relationship and Chemotherapeutic Potential for the Treatment of Leukemia (English)

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4 September 2017

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4

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4 September 2017

José C J M D S Menezes

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José C J M D S Menezes

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1

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author name string

Barbora Orlikova

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2

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4 September 2017

Franck Morceau

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3

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4 September 2017

13 October 2015

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Critical Reviews in Food Science and Nutrition

4 September 2017

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4 September 2017

56 Suppl 1

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4 September 2017

S4-S28

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Novel insights into the antiproliferative effects and synergism of quercetin and menadione in human leukemia Jurkat T cells

4 September 2017

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https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Anti-cancer potential of flavonoids: recent trends and future perspectives.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Influence of galangin on HL-60 cell proliferation and survival

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Ethyl acetate extract and its major constituent, isorhamnetin 3-O-rutinoside, from Nitraria retusa leaves, promote apoptosis of human myelogenous erythroleukaemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Flavopiridol in chronic lymphocytic leukemia: a concise review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Synthesis of demethylxanthohumol, a new potent apoptosis-inducing agent from hops

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Ability of prenylflavanones present in hops to induce apoptosis in a human Burkitt lymphoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Enhancement of flavonoid ability to cross the blood-brain barrier of rats by co-administration with α-tocopherol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

The influence of 8-prenylnaringenin on the activity of voltage-gated Kv1.3 potassium channels in human Jurkat T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Pharmacokinetics and bioavailability of quercetin glycosides in humans

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Advances in flavonoid research since 1992.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Apigenin decreases cell viability and telomerase activity in human leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Flavonoid-induced glutathione depletion: potential implications for cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Apoptotic effects of chrysin in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukemia (HL-60) cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

The anticancer potential of flavonoids isolated from the stem bark of Erythrina suberosa through induction of apoptosis and inhibition of STAT signaling pathway in human leukemia HL-60 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Methylation suppresses the proteasome-inhibitory function of green tea polyphenols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Cytotoxic and apoptotic effects of prenylflavonoid artonin B in human acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Differentiation therapy of human cancer: basic science and clinical applications

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Growth inhibitory and apoptosis inducing by effects of total flavonoids from Lysimachia clethroides Duby in human chronic myeloid leukemia K562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Adamantyl arotinoids that inhibit IκB kinase α and IκB kinase β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

2(+/-)-7,8,3',4',5'-Pentamethoxyflavan induces G2/M phase arrest and apoptosis in HL60 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Apoptotic events induced by synthetic naphthylchalcones in human acute leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Dietary bioflavonoids induce apoptosis in human leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Anti-leukemic activity of Wattakaka volubilis leaf extract against human myeloid leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Structure-activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Methylenedioxy flavonoids: assessment of cytotoxic and anti-cancer potential in human leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Apoptosis induction of human leukemia U937 cells by 7,8-dihydroxyflavone hydrate through modulation of the Bcl-2 family of proteins and the MAPKs signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Morin, a flavonoid from moraceae, induces apoptosis by induction of BAD protein in human leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

III-10, a newly synthesized flavonoid, induced differentiation of human U937 leukemia cells via PKCδ activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Flavonoids: Promising anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Cytotoxic effect of flavonoids on leukemia cells and normal cells of human blood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Dietary flavonoids: bioavailability, metabolic effects, and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Probing antioxidant activity of 2'-hydroxychalcones: crystal and molecular structures, in vitro antiproliferative studies and in vivo effects on glucose regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Cytotoxic and apoptogenic effect of Swietenia mahagoni (L.) Jacq. leaf extract in human leukemic cell lines U937, K562 and HL-60.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Acetyl derivate of quercetin increases the sensitivity of human leukemia cells toward apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Quercetin solid lipid microparticles: a flavonoid for inhalation lung delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Anti-carcinogenic effects of the flavonoid luteolin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Casticin induces leukemic cell death through apoptosis and mitotic catastrophe

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Apigenin: a promising molecule for cancer prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Therapeutic potential of apigenin, a plant flavonoid, for imatinib-sensitive and resistant chronic myeloid leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Flavonoids as RTK inhibitors and potential anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Flavonoid bioavailability and attempts for bioavailability enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Improvement in solubility and dissolution rate of flavonoids by complexation with beta-cyclodextrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Height and breast cancer risk--the bias of self-reported versus measured results. Comments on height and breast cancer risk, Tavani et al., Eur J Cancer 1998, 34, 543-547.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

CXCL12/CXCR4 axis confers adriamycin resistance to human chronic myelogenous leukemia and oroxylin A improves the sensitivity of K562/ADM cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Delivering flavonoids into solid tumors using nanotechnologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Involvement of extrinsic and intrinsic apoptotic pathways together with endoplasmic reticulum stress in cell death induced by naphthylchalcones in a leukemic cell line: advantages of multi-target action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Structure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Enhanced lymphatic transport of bioactive lipids: cell culture study of polymethoxyflavone incorporation into chylomicrons

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Flavonoids in food and their health benefits

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Induction of apoptosis in K562 human leukemia cells by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

6-C-methyl flavonoids isolated from Pinus densata inhibit the proliferation and promote the apoptosis of the HL-60 human promyelocytic leukaemia cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Luteolin from Flos Chrysanthemi and its derivatives: New small molecule Bcl-2 protein inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2015.1074532

10.1080/10408398.2015.1074532

21 January 2018

Identifiers

DOI

1 reference

release_fffirbwonrdcnl6hkabkh3vcnu

4 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fffirbwonrdcnl6hkabkh3vcnu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference