(Q38667942)

5 September 2017

Review: Sporadic Parkinson's disease: development and distribution of α-synuclein pathology (English)

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5 September 2017

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K Del Tredici

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PubMed ID

26662475

5 September 2017

H Braak

series ordinal

2

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PubMed ID

26662475

5 September 2017

language of work or name

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13 December 2015

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Neuropathology and Applied Neurobiology

5 September 2017

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5 September 2017

42

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5 September 2017

1

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5 September 2017

33-50

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Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

5 September 2017

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Epidemiology of Parkinson's disease

21 January 2018

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The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans

21 January 2018

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The intermediolateral nucleus and Clarke's column in Parkinson's disease.

21 January 2018

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Abnormalities of rate-corrected QT intervals in Parkinson's disease-a comparison with multiple system atrophy and progressive supranuclear palsy.

21 January 2018

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Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease.

21 January 2018

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Lewy body pathology involves cutaneous nerves.

21 January 2018

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Lesions outside the CNS in Parkinson's disease

21 January 2018

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Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders

21 January 2018

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Spinal cord lesions in sporadic Parkinson's disease.

21 January 2018

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What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?

21 January 2018

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Parkinson's disease: chameleons and mimics

21 January 2018

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Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases

21 January 2018

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Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects.

21 January 2018

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Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

21 January 2018

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Alpha-synuclein in Lewy bodies

21 January 2018

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NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.

21 January 2018

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Neuropathology of synuclein aggregates

21 January 2018

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The cellular pathology of Parkinson's disease

21 January 2018

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Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses

21 January 2018

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Parkinson's disease: Distribution of Lewy bodies and monoamine neuron system

21 January 2018

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Poor and protracted myelination as a contributory factor to neurodegenerative disorders.

21 January 2018

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Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review

21 January 2018

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The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease

21 January 2018

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The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease

21 January 2018

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Amygdala pathology in Parkinson's disease

21 January 2018

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Immunoreactivity profile of hippocampal CA2/3 neurites in diffuse Lewy body disease.

21 January 2018

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Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

21 January 2018

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Accumulation of phosphorylated alpha-synuclein in aging human brain.

21 January 2018

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Alpha-synuclein and the Lewy body disorders

21 January 2018

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The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases

21 January 2018

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100 years of Lewy pathology.

21 January 2018

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Alpha-synuclein: normal function and role in neurodegenerative diseases.

21 January 2018

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Physiological and pathological properties of alpha-synuclein

21 January 2018

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Atypical parkinsonism: an update

21 January 2018

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Red blood cells are the major source of alpha-synuclein in blood.

21 January 2018

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Alpha-synuclein is not a requisite component of synaptic boutons in the adult human central nervous system.

21 January 2018

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

21 January 2018

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Targeting the chameleon: a focused look at α-synuclein and its roles in neurodegeneration

21 January 2018

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NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein

21 January 2018

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

21 January 2018

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Structure of the toxic core of α-synuclein from invisible crystals

21 January 2018

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Parkinson's disease: Crystals of a toxic core

21 January 2018

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

21 January 2018

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Molecular chaperones, α-synuclein, and neurodegeneration

21 January 2018

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Defining the native state of α-synuclein

21 January 2018

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Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

21 January 2018

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α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

21 January 2018

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Properties of native brain α-synuclein

21 January 2018

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Alpha-synuclein biology in Lewy body diseases

21 January 2018

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Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

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Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease

21 January 2018

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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

21 January 2018

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Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.

21 January 2018

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Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice

21 January 2018

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Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells

21 January 2018

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Critical role of truncated α-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease

21 January 2018

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Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

21 January 2018

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Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry

21 January 2018

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The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates

21 January 2018

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The Lewy body in Parkinson's disease and related neurodegenerative disorders

21 January 2018

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Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies.

21 January 2018

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Cell type specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies

21 January 2018

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Alteration of Upstream Autophagy-Related Proteins (ULK1, ULK2, Beclin1, VPS34 and AMBRA1) in Lewy Body Disease

21 January 2018

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Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

21 January 2018

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Proteasomal function is impaired in substantia nigra in Parkinson's disease

21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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Autophagy and neurodegeneration: when the cleaning crew goes on strike

21 January 2018

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Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

21 January 2018

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Pathogenic lysosomal depletion in Parkinson's disease

21 January 2018

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The role of autophagy in Parkinson's disease.

21 January 2018

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Pathology and neurotransmitter abnormalities of dementia with Lewy bodies

21 January 2018

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Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

21 January 2018

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Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals.

21 January 2018

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Axonal transport defects: a common theme in neurodegenerative diseases

21 January 2018

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Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: a speculative synthesis

21 January 2018

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Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

21 January 2018

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

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Autophagy in the Pathogenesis of Disease

21 January 2018

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Α-synuclein misfolding and Parkinson's disease

21 January 2018

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Pathogenesis of Parkinson's disease: emerging role of molecular chaperones

21 January 2018

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Preventing α-synuclein aggregation: the role of the small heat-shock molecular chaperone proteins

21 January 2018

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Viruses and neurodegeneration

21 January 2018

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Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets

21 January 2018

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Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough

21 January 2018

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The Parkinson's complex: parkinsonism is just the tip of the iceberg

21 January 2018

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Beating a dead horse: dopamine and Parkinson disease

21 January 2018

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Neuropathology of non-motor features of Parkinson disease

21 January 2018

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Milestones in Parkinson's disease--clinical and pathologic features

21 January 2018

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Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

21 January 2018

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Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

21 January 2018

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Association of olfactory dysfunction with incidental Lewy bodies.

21 January 2018

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Bowel movement frequency in late-life and incidental Lewy bodies

21 January 2018

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Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study.

21 January 2018

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Incidental Lewy body disease and preclinical Parkinson disease

21 January 2018

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Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease

21 January 2018

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Lewy body pathology in normal elderly subjects

21 January 2018

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When does Parkinson disease start?

21 January 2018

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Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease

21 January 2018

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Lewy pathology and neurodegeneration in premotor Parkinson's disease

21 January 2018

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Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.

21 January 2018

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21 January 2018

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Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism

21 January 2018

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Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease

21 January 2018

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Diagnosis and the premotor phase of Parkinson disease

21 January 2018

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Molecular and clinical prodrome of Parkinson disease: implications for treatment

21 January 2018

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The significance of defining preclinical or prodromal Parkinson's disease

21 January 2018

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Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease

21 January 2018

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Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease

21 January 2018

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Is Parkinson's disease a primary olfactory disorder?

21 January 2018

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A timeline for Parkinson's disease

21 January 2018

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21 January 2018

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Olfactory dysfunction in Parkinson disease

21 January 2018

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Olfaction in neurodegenerative disorder

21 January 2018

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Idiopathic hyposmia as a preclinical sign of Parkinson's disease

21 January 2018

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Olfactory loss may be a first sign of idiopathic Parkinson's disease.

21 January 2018

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Frequency of bowel movements and the future risk of Parkinson's disease

21 January 2018

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Non-motor symptoms of Parkinson's disease: diagnosis and management

21 January 2018

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Non-motor symptoms in Parkinson's disease

21 January 2018

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A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials

21 January 2018

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Autonomic involvement in Parkinson's disease: pathology, pathophysiology, clinical features and possible peripheral biomarkers

21 January 2018

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Identifying prodromal Parkinson's disease: pre-motor disorders in Parkinson's disease

21 January 2018

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The spectrum of nonmotor symptoms in early Parkinson disease

21 January 2018

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Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease.

21 January 2018

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Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT.

21 January 2018

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REM sleep behavior disorder: a possible early marker for synucleinopathies.

21 January 2018

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Parkinson's disease: before the motor symptoms and beyond

21 January 2018

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Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response

21 January 2018

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The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years

21 January 2018

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Parkinson disease with dementia: comparing patients with and without Alzheimer pathology

21 January 2018

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Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study).

21 January 2018

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Neuropathologic substrates of Parkinson disease dementia

21 January 2018

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Mortality in Parkinson's disease: a 38-year follow-up study.

21 January 2018

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Parkinson's disease: a dual-hit hypothesis

21 January 2018

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Parkinson's disease: the dual hit theory revisited

21 January 2018

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Neuropathology underlying clinical variability in patients with synucleinopathies

21 January 2018

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Patterns of α-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease

21 January 2018

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Stages in the development of Parkinson's disease-related pathology

21 January 2018

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Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered

21 January 2018

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Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb

21 January 2018

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Evidence in favor of Braak staging of Parkinson's disease.

21 January 2018

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Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?

21 January 2018

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Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

21 January 2018

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The anterior olfactory nucleus in Parkinson's disease

21 January 2018

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The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases

21 January 2018

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Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

21 January 2018

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Alpha-synuclein pathology in the olfactory pathways of dementia patients.

21 January 2018

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The olfactory vector hypothesis of neurodegenerative disease: is it viable?

21 January 2018

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Olfactory pathogenesis of idiopathic Parkinson disease revisited

21 January 2018

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Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

21 January 2018

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Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease

21 January 2018

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Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.

21 January 2018

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Infectious agents and neurodegeneration

21 January 2018

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The locus ceruleus norepinephrine system: functional organization and potential clinical significance

21 January 2018

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Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons

21 January 2018

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α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways

21 January 2018

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Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

21 January 2018

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The human amygdaloid complex: A cytologic and histochemical atlas using Nissl, myelin, acetylcholinesterase and nicotinamide adenine dinucleotide phosphate diaphorase staining

21 January 2018

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The pedunculopontine nucleus and Parkinson's disease

21 January 2018

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The central nucleus of the amygdala projection to dopamine subpopulations in primates.

21 January 2018

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Direct spread of reovirus from the intestinal lumen to the central nervous system through vagal autonomic nerve fibers

21 January 2018

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Potential role of viruses in neurodegeneration

21 January 2018

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Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

21 January 2018

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The human entorhinal cortex: normal morphology and lamina-specific pathology in various diseases

21 January 2018

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The preclinical phase of the pathological process underlying sporadic Alzheimer's disease

21 January 2018

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Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps

21 January 2018

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Cortical Lewy body-containing neurons are pyramidal cells: laser confocal imaging of double-immunolabeled sections with anti-ubiquitin and SMI32.

21 January 2018

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Cortical structure predicts the pattern of corticocortical connections.

21 January 2018

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Inter- and intra-laminar connections of pyramidal cells in the neocortex

21 January 2018

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Specialized elements of orbitofrontal cortex in primates

21 January 2018

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Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

21 January 2018

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View point: etiology in Parkinson's disease. Dual hit or spreading intoxication

21 January 2018

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Considerations on the role of environmental toxins in idiopathic Parkinson's disease pathophysiology

21 January 2018

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α-Synuclein pathology in the cranial and spinal nerves in Lewy body disease.

21 January 2018

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Enteric nervous system: functional organization and neurologic implications

21 January 2018

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Neural control of the gastrointestinal tract: implications for Parkinson disease

21 January 2018

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

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Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats.

21 January 2018

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Caudo-rostral brain spreading of α-synuclein through vagal connections

21 January 2018

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Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

21 January 2018

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Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

21 January 2018

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Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease?

21 January 2018

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Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system.

21 January 2018

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Vagotomy and subsequent risk of Parkinson's disease

21 January 2018

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Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

21 January 2018

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Axonal and transneuronal transport in the transmission of neurological disease: potential role in system degenerations, including Alzheimer's disease

21 January 2018

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Research in motion: the enigma of Parkinson's disease pathology spread

21 January 2018

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Are synucleinopathies prion-like disorders?

21 January 2018

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The propagation of prion-like protein inclusions in neurodegenerative diseases

21 January 2018

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Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies

21 January 2018

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A deadly spread: cellular mechanisms of α-synuclein transfer

21 January 2018

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Exosomal cell-to-cell transmission of alpha synuclein oligomers.

21 January 2018

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Can Parkinson's disease pathology be propagated from one neuron to another?

21 January 2018

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Beyond α-synuclein transfer: pathology propagation in Parkinson's disease

21 January 2018

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Structural and functional characterization of two alpha-synuclein strains

21 January 2018

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α-Synuclein: the long distance runner

21 January 2018

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

21 January 2018

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Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?

21 January 2018

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Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology?

21 January 2018

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Modeling Lewy pathology propagation in Parkinson's disease

21 January 2018

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Alpha-synuclein spreading in Parkinson's disease

21 January 2018

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Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration

21 January 2018

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Parkinson's disease as a member of Prion-like disorders

21 January 2018

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Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases

21 January 2018

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α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

21 January 2018

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Dietary fat intake, pesticide use, and Parkinson's disease

21 January 2018

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Predominant affection of the blue cone pathway in Parkinson's disease.

21 January 2018

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Sensory deficit in Parkinson's disease: evidence of a cutaneous denervation

21 January 2018

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Cutaneous neuropathy in Parkinson's disease: a window into brain pathology

21 January 2018

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Correlation Between Structural and Functional Retinal Changes in Parkinson Disease.

21 January 2018

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Alpha-Synuclein Pathology in Sensory Nerve Terminals of the Upper Aerodigestive Tract of Parkinson's Disease Patients

21 January 2018

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Types of neurons in the enteric nervous system.

21 January 2018

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Alpha-synuclein immunoreactivity patterns in the enteric nervous system.

21 January 2018

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New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies

21 January 2018

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The awakening of α-synuclein

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/NAN.12298

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5 September 2017

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PubMed ID

26662475