(Q38678741)

5 September 2017

1 reference

title

Targeting nuclear receptors for the treatment of fatty liver disease (English)

1 reference

5 September 2017

Naoki Tanaka

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6659998&resulttype=core&format=json

15 May 2020

Toshifumi Aoyama

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6659998&resulttype=core&format=json

15 May 2020

Shioko Kimura

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6659998&resulttype=core&format=json

15 May 2020

Frank J Gonzalez

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6659998&resulttype=core&format=json

15 May 2020

publication date

22 May 2017

1 reference

28546081

Pharmacology & Therapeutics

5 September 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6659998&resulttype=core&format=json

15 May 2020

volume

179

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6659998&resulttype=core&format=json

15 May 2020

page(s)

142-157

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6659998&resulttype=core&format=json

Identification of a nuclear receptor for bile acids

15 May 2020

cites work

1 reference

12 December 2020

Bezafibrate for tamoxifen-induced non-alcoholic steatohepatitis

1 reference

12 December 2020

Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity

1 reference

12 December 2020

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

1 reference

12 December 2020

The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein

1 reference

12 December 2020

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

1 reference

12 December 2020

Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting.

1 reference

12 December 2020

Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor

1 reference

12 December 2020

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

1 reference

12 December 2020

Peroxisome proliferator-activated receptors and hepatic stellate cell activation

1 reference

12 December 2020

Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators

1 reference

12 December 2020

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

1 reference

12 December 2020

Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein

1 reference

12 December 2020

Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate

1 reference

12 December 2020

DNA Binding-Independent Induction of I B Gene Transcription by PPAR

1 reference

12 December 2020

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

1 reference

12 December 2020

Differential nuclear receptor signalling from DR4-type response elements

1 reference

12 December 2020

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

1 reference

12 December 2020

Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression

1 reference

12 December 2020

Pathogenesis and pathophysiology of citrin (a mitochondrial aspartate glutamate carrier) deficiency

1 reference

12 December 2020

Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

1 reference

12 December 2020

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

1 reference

12 December 2020

Bezafibrate is a dual ligand for PPARalpha and PPARbeta: studies using null mice

1 reference

12 December 2020

Prevention of ethanol-induced liver injury in rats by an agonist of peroxisome proliferator-activated receptor-gamma, pioglitazone

1 reference

12 December 2020

Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background

1 reference

12 December 2020

CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor

1 reference

12 December 2020

Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes.

1 reference

12 December 2020

Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met

1 reference

12 December 2020

Peroxisome proliferator-activated receptor alpha target genes

1 reference

12 December 2020

Beyond insulin resistance in NASH: TNF-alpha or adiponectin?

1 reference

12 December 2020

Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage

1 reference

12 December 2020

PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats

1 reference

12 December 2020

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

1 reference

12 December 2020

Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

1 reference

12 December 2020

FGF-21 as a novel metabolic regulator

1 reference

12 December 2020

Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes.

1 reference

12 December 2020

Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention

1 reference

12 December 2020

5-Oxo-ETE analogs and the proliferation of cancer cells

1 reference

12 December 2020

Laparoscopic findings in patients with nonalcoholic steatohepatitis

1 reference

12 December 2020

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

1 reference

12 December 2020

PPARdelta regulates glucose metabolism and insulin sensitivity

1 reference

12 December 2020

A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway

1 reference

12 December 2020

Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet

1 reference

12 December 2020

A lean man with nonalcoholic fatty liver disease

1 reference

12 December 2020

The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis

1 reference

12 December 2020

Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population

1 reference

12 December 2020

Long-term follow-up of patients with NAFLD and elevated liver enzymes

1 reference

12 December 2020

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

1 reference

12 December 2020

In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway

1 reference

12 December 2020

Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression

1 reference

12 December 2020

Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice

1 reference

12 December 2020

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor

1 reference

12 December 2020

Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation

1 reference

12 December 2020

Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model

1 reference

12 December 2020

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

1 reference

12 December 2020

13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells

1 reference

12 December 2020

PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

1 reference

12 December 2020

Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis

1 reference

12 December 2020

PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators

1 reference

12 December 2020

Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice

1 reference

12 December 2020

Analysis of Nuclear Receptor Pseudogenes in Vertebrates: How the Silent Tell Their Stories

1 reference

12 December 2020

Pancreatic exocrine insufficiency: a rare cause of nonalcoholic steatohepatitis.

1 reference

12 December 2020

PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice

1 reference

12 December 2020

Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis

1 reference

12 December 2020

A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease

1 reference

12 December 2020

Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27.

1 reference

12 December 2020

Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised

1 reference

12 December 2020

Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial

1 reference

12 December 2020

Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease

1 reference

12 December 2020

Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression

1 reference

12 December 2020

Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice

1 reference

12 December 2020

Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: a novel peroxisome proliferator-activated receptor alpha-independent mechanism

1 reference

12 December 2020

Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice

1 reference

12 December 2020

Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress

1 reference

12 December 2020

Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization

1 reference

12 December 2020

Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis.

1 reference

12 December 2020

PXR and CAR in energy metabolism

1 reference

12 December 2020

The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity

1 reference

12 December 2020

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

1 reference

12 December 2020

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

1 reference

12 December 2020

Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).

1 reference

12 December 2020

Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism.

1 reference

12 December 2020

The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease

1 reference

12 December 2020

Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection

1 reference

12 December 2020

Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits

1 reference

12 December 2020

Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

1 reference

12 December 2020

Serum fragmented cytokeratin 18 levels reflect the histologic activity score of nonalcoholic fatty liver disease more accurately than serum alanine aminotransferase levels

1 reference

12 December 2020

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response

1 reference

12 December 2020

Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARgamma agonist KR62776.

1 reference

12 December 2020

Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-alpha agonist

1 reference

12 December 2020

Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

1 reference

12 December 2020

Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro.

1 reference

12 December 2020

Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease

1 reference

12 December 2020

Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation

1 reference

12 December 2020

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.

1 reference

12 December 2020

Down-regulation of SREBP-1c is associated with the development of burned-out NASH.

1 reference

12 December 2020

Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis

1 reference

12 December 2020

Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy.

1 reference

12 December 2020

Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease

1 reference

12 December 2020

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1 reference

12 December 2020

The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

1 reference

12 December 2020

Transgenic animal models in toxicology: historical perspectives and future outlook.

1 reference

12 December 2020

A role for central nervous system PPAR-γ in the regulation of energy balance

1 reference

12 December 2020

Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones

1 reference

12 December 2020

Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha)

1 reference

12 December 2020

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

1 reference

12 December 2020

Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor

1 reference

12 December 2020

Human fatty liver disease: old questions and new insights

1 reference

12 December 2020

Thiazolidinediones are potent inducers of fibroblast growth factor 21 expression in the liver.

1 reference

12 December 2020

Variations in ATP-binding cassette transporter regulation during the progression of human nonalcoholic fatty liver disease

1 reference

12 December 2020

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.

1 reference

12 December 2020

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.

1 reference

12 December 2020

Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study

1 reference

12 December 2020

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

1 reference

12 December 2020

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

1 reference

12 December 2020

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

1 reference

12 December 2020

Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21

1 reference

12 December 2020

Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice

1 reference

12 December 2020

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

1 reference

12 December 2020

Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.

1 reference

12 December 2020

CCAAT/enhancer binding protein β deletion increases mitochondrial function and protects mice from LXR-induced hepatic steatosis

1 reference

12 December 2020

The impact of hepatic steatosis on liver regeneration after partial hepatectomy.

1 reference

12 December 2020

Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance

1 reference

12 December 2020

MicroRNA-1 and microRNA-206 suppress LXRα-induced lipogenesis in hepatocytes

1 reference

12 December 2020

Pregnane X receptor agonists impair postprandial glucose tolerance.

1 reference

12 December 2020

Pleiotropic roles of bile acids in metabolism

1 reference

12 December 2020

PPARγ signaling and metabolism: the good, the bad and the future

1 reference

12 December 2020

Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells

1 reference

12 December 2020

PPARβ/δ modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity.

1 reference

12 December 2020

Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis

1 reference

12 December 2020

Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3.

1 reference

12 December 2020

Bile acid receptors in non-alcoholic fatty liver disease

1 reference

12 December 2020

Pathological bacterial translocation in liver cirrhosis

1 reference

12 December 2020

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

1 reference

12 December 2020

All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.

1 reference

12 December 2020

Adiponectin, driver or passenger on the road to insulin sensitivity?

1 reference

12 December 2020

Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.

1 reference

12 December 2020

Hepatic molecular effects of rosiglitazone in human non-alcoholic steatohepatitis suggest long-term pro-inflammatory damage

1 reference

12 December 2020

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.

1 reference

12 December 2020

Role of pregnane X receptor in obesity and glucose homeostasis in male mice

1 reference

12 December 2020

Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers

1 reference

12 December 2020

Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice

1 reference

12 December 2020

Diagnosis and classification of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: Current concepts and remaining challenges

1 reference

12 December 2020

Nuclear Receptors, RXR, and the Big Bang

1 reference

12 December 2020

The FXR agonist 6ECDCA reduces hepatic steatosis and oxidative stress induced by ethanol and low-protein diet in mice

1 reference

12 December 2020

Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice

1 reference

12 December 2020

Inventing new medicines: The FGF21 story

1 reference

12 December 2020

Metabolically healthy obesity, presence or absence of fatty liver, and risk of type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 20 (TOPICS 20).

1 reference

12 December 2020

Liver X receptors in lipid metabolism: opportunities for drug discovery

1 reference

12 December 2020

Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes

1 reference

12 December 2020

Pathway-based toxicity: history, current approaches and liver fibrosis and steatosis as prototypes

1 reference

12 December 2020

Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation

1 reference

12 December 2020

PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.

1 reference

12 December 2020

Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease

1 reference

12 December 2020

Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis

1 reference

12 December 2020

Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet

1 reference

12 December 2020

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.

1 reference

12 December 2020

Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor

1 reference

12 December 2020

Targeting xenobiotic receptors PXR and CAR in human diseases

1 reference

12 December 2020

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

1 reference

12 December 2020

Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice.

1 reference

12 December 2020

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.

1 reference

12 December 2020

Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα.

1 reference

12 December 2020

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

1 reference

12 December 2020

SLC13A5 is a novel transcriptional target of the pregnane X receptor and sensitizes drug-induced steatosis in human liver

1 reference

12 December 2020

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

1 reference

12 December 2020

Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet

1 reference

12 December 2020

The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

1 reference

12 December 2020

Environmental pollutants directly affect the liver X receptor alpha activity: Kinetic and thermodynamic characterization of binding

1 reference

12 December 2020

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

1 reference

12 December 2020

Regulation of gene expression by CAR: an update

1 reference

12 December 2020

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans

1 reference

12 December 2020

The Hierarchical Model of NAFLD: Prognostic Significance of Histologic Features in NASH.

1 reference

12 December 2020

Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case.

1 reference

12 December 2020

The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways

1 reference

12 December 2020

Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases

1 reference

12 December 2020

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

1 reference

12 December 2020

Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy

1 reference

12 December 2020

Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells.

1 reference

12 December 2020

Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid

1 reference

12 December 2020

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD).

1 reference

12 December 2020

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.

1 reference

12 December 2020

Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

1 reference

12 December 2020

Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis

1 reference

12 December 2020

Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis.

1 reference

12 December 2020

Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection

1 reference

12 December 2020

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus: A Randomized Trial.

1 reference

12 December 2020

Editor's Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver

1 reference

12 December 2020

FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists.

1 reference

12 December 2020

An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease.

1 reference

12 December 2020

PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis

1 reference

12 December 2020

Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.

1 reference

12 December 2020

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

1 reference

12 December 2020

Roles of Peroxisome Proliferator-Activated Receptor β/δ in skeletal muscle physiology

1 reference

12 December 2020

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice

1 reference

12 December 2020

Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells.

1 reference

12 December 2020

Current and emergent pharmacologic treatments for irritable bowel syndrome with diarrhea: evidence-based treatment in practice

1 reference

12 December 2020

Association between endotoxemia and histological features of nonalcoholic fatty liver disease

1 reference

12 December 2020

An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice.

1 reference

12 December 2020

Effects of the hepatocarcinogen nafenopin, a peroxisome proliferator, on the activities of rat liver glutathione-requiring enzymes and catalase in comparison to the action of phenobarbital.

1 reference

12 December 2020

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1 reference

12 December 2020

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

1 reference

12 December 2020

Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease

1 reference

12 December 2020

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

1 reference

12 December 2020

Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

1 reference

12 December 2020

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1 reference

12 December 2020

LXR, a nuclear receptor that defines a distinct retinoid response pathway

1 reference

12 December 2020

Identification of a nuclear receptor that is activated by farnesol metabolites

1 reference

12 December 2020

NER, a new member of the gene family encoding the human steroid hormone nuclear receptor

1 reference

12 December 2020

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

1 reference

12 December 2020

Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study

1 reference

12 December 2020

Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)

1 reference

12 December 2020

Steatohepatitis: a tale of two "hits"?

1 reference

12 December 2020

Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators

1 reference

12 December 2020

Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.

1 reference

12 December 2020

10.1016/J.PHARMTHERA.2017.05.011

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6659998&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6659998&resulttype=core&format=json

15 May 2020

28546081

1 reference