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Targeting xenobiotic receptors PXR and CAR in human diseases
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title
Targeting xenobiotic receptors PXR and CAR in human diseases
(English)
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author name string
Monimoy Banerjee
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1
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Delira Robbins
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2
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Taosheng Chen
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3
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language of work or name
English
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PubMed
publication date
May 2015
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PubMed
published in
Drug Discovery Today
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stated in
PubMed
volume
20
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PubMed
issue
5
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PubMed
page(s)
618-28
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PubMed
cites work
Modulation of xenobiotic receptors by steroids
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Targeting xenobiotic receptors PXR and CAR for metabolic diseases
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21 March 2017
Pregnane X receptor as a target for treatment of inflammatory bowel disorders
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21 March 2017
Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).
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21 March 2017
2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin
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21 March 2017
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
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21 March 2017
Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRα
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21 March 2017
Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721
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21 March 2017
Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism
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21 March 2017
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity
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21 March 2017
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
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Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site
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21 March 2017
Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor
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21 March 2017
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital
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21 March 2017
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
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21 March 2017
Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR
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21 March 2017
Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2
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21 March 2017
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
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21 March 2017
Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity
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21 March 2017
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
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7 April 2017
Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.
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28 September 2017
Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.
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28 September 2017
Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes
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28 September 2017
The role of FOXO1 in β-cell failure and type 2 diabetes mellitus
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28 September 2017
Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor
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28 September 2017
Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity
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28 September 2017
Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR
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28 September 2017
Allosteric controls of nuclear receptor function in the regulation of transcription
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28 September 2017
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy
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28 September 2017
Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond
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28 September 2017
3D structures and ligand specificities of nuclear xenobiotic receptors CAR, PXR and VDR.
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28 September 2017
Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective
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28 September 2017
The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies
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28 September 2017
Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches
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28 September 2017
Ligand- and structure-based pregnane X receptor models
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28 September 2017
Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery
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28 September 2017
Role of CAR and PXR in xenobiotic sensing and metabolism
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28 September 2017
Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma
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28 September 2017
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice
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28 September 2017
In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation
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28 September 2017
Nuclear receptor PXR, transcriptional circuits and metabolic relevance
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28 September 2017
Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease
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28 September 2017
Identification of clinically used drugs that activate pregnane X receptors
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28 September 2017
Overcoming drug resistance by regulating nuclear receptors
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28 September 2017
Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B
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28 September 2017
Orphan nuclear receptors as targets for drug development
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28 September 2017
Activation of xenobiotic receptors: driving into the nucleus
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28 September 2017
Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening
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28 September 2017
Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects
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28 September 2017
Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists
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28 September 2017
Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.
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28 September 2017
Computational discovery of novel low micromolar human pregnane X receptor antagonists
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28 September 2017
The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor
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28 September 2017
The antiapoptotic role of pregnane X receptor in human colon cancer cells
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28 September 2017
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor
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28 September 2017
A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor
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28 September 2017
Human pregnane X receptor and resistance to chemotherapy in prostate cancer
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28 September 2017
Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites
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28 September 2017
Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.
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28 September 2017
CAR and PXR: the xenobiotic-sensing receptors
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28 September 2017
The nuclear receptor superfamily and drug discovery
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28 September 2017
Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligands.
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28 September 2017
Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation
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28 September 2017
Here be dragons: docking and screening in an uncharted region of chemical space
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28 September 2017
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes
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PubMed Central
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28 September 2017
Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.
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PubMed Central
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28 September 2017
A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.
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28 September 2017
Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors
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28 September 2017
A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta
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PubMed Central
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28 September 2017
Gene- and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences
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28 September 2017
Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans
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28 September 2017
Pregnane X receptor agonists impair postprandial glucose tolerance.
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31 May 2018
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis
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31 May 2018
Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis.
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31 May 2018
Inhibition of gluconeogenesis in isolated rat hepatocytes after chronic treatment with phenobarbital
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PubMed Central
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31 May 2018
Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
Nuclear Receptors as Drug Targets: New Developments in Coregulators, Orphan Receptors and Major Therapeutic Areas
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stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
retrieved
28 November 2018
Inhibitors of dihydrodipicolinate reductase, a key enzyme of the diaminopimelate pathway of Mycobacterium tuberculosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
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28 November 2018
Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433851
retrieved
28 November 2018
Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25463033
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25463033
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The pregnane X receptor: from bench to bedside
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25463033
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.DRUDIS.2014.11.011
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1261446
OpenCitations bibliographic resource ID
1261446
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1261446
PMC publication ID
4433851
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1261446
PubMed publication ID
25463033
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1261446
ResearchGate publication ID
268695876
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