(Q38074718)

28 August 2017

1 reference

title

Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond (English)

1 reference

28 August 2017

1 reference

Xiaojuan Chai

1

1 reference

28 August 2017

Su Zeng

series ordinal

2

1 reference

28 August 2017

Wen Xie

series ordinal

3

1 reference

28 August 2017

language of work or name

English

0 references

publication date

17 January 2013

1 reference

Expert Opinion on Drug Metabolism & Toxicology

28 August 2017

1 reference

28 August 2017

9

1 reference

28 August 2017

3

1 reference

28 August 2017

253-266

1 reference

Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism

28 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The RXR heterodimers and orphan receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Mechanisms of cytochrome P450 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Active nuclear receptors exhibit highly correlated AF-2 domain motions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Determinants of target gene specificity for steroid/thyroid hormone receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

ChIPing the cistrome of PXR in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear fa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The effect of rifampin treatment on intestinal expression of human MRP transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Overcoming drug resistance by regulating nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Activated pregnenolone X-receptor is a target for ketoconazole and its analogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Computational discovery of novel low micromolar human pregnane X receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Insulin regulation of PEPCK gene expression: a model for rapid and reversible modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The roles of nuclear receptors CAR and PXR in hepatic energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The role of stearoyl-CoA desaturase in the control of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

CD36: implications in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The enzymes, regulation, and genetics of bile acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

PXR and the regulation of apoA1 and HDL-cholesterol in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Expression of the pregnane X receptor in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Targeting farnesoid X receptor for liver and metabolic disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The continuing importance of bile acids in liver and intestinal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting P

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Pregnane X receptor is SUMOylated to repress the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Long-term changes in cyclosporine pharmacokinetics after renal transplantation in children: evidence for saturable presystemic metabolism and effect of NR1I2 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The role of CYP2B6 in human xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The importance of cytochrome P450 2B6 in the human metabolism of environmental chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

CAR and PXR: xenosensors of endocrine disrupters?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Choice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Drug interactions in childhood cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Effects of phenobarbital and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene on differentiated functions in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Inhibition of gluconeogenesis in isolated rat hepatocytes after chronic treatment with phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

A functional cross-talk between liver X receptor-α and constitutive androstane receptor links lipogenesis and xenobiotic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Functional analysis of four naturally occurring variants of human constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Pharmacogenetics of the constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Alternative splicing within the ligand binding domain of the human constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Alternatively spliced isoforms of the human constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

Eleven Novel Single Nucleotide Polymorphisms in the NRH2 (PXR) Gene, Pour of which Induce Non-synonymous Amino Acid Alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754010

10.1517/17425255.2013.754010

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference