(Q38750197)

6 September 2017

D186/D190 is an allele-dependent determinant of HIV-1 Nef function (English)

1 reference

6 September 2017

1

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13 June 2020

Bettina Stolp

2

1 reference

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13 June 2020

Matthias Geyer

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27560372%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Oliver T Fackler

6

1 reference

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13 June 2020

author name string

Verena Böhmer

3

1 reference

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13 June 2020

Erez Raz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27560372%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

language of work or name

English

0 references

publication date

22 August 2016

1 reference

6 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27560372%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

498

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27560372%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

44-56

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27560372%20AND%20SRC:MED&resulttype=core&format=json

HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation.

13 June 2020

cites work

1 reference

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A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.

7 January 2021

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Lentivirus Nef specifically activates Pak2.

7 January 2021

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The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

7 January 2021

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Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.

7 January 2021

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Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions

7 January 2021

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HIV Nef inhibits T cell migration.

7 January 2021

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The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

7 January 2021

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

7 January 2021

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

7 January 2021

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

7 January 2021

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An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.

7 January 2021

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Guidance of primordial germ cell migration by the chemokine SDF-1.

7 January 2021

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Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

7 January 2021

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p21-activated kinase 1 plays a critical role in cellular activation by Nef.

7 January 2021

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Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

7 January 2021

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Adding new dimensions: towards an integrative understanding of HIV-1 spread.

7 January 2021

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

7 January 2021

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Structure--function relationships in HIV-1 Nef.

7 January 2021

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Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef.

7 January 2021

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Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice

7 January 2021

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HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins

7 January 2021

1 reference

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HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling

7 January 2021

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The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity

7 January 2021

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Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly

7 January 2021

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Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex

7 January 2021

1 reference

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HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis

7 January 2021

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Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

7 January 2021

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Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells

7 January 2021

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

7 January 2021

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

7 January 2021

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Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin

7 January 2021

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Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1.

7 January 2021

1 reference

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Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase

7 January 2021

1 reference

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HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases

7 January 2021

1 reference

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Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

7 January 2021

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Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody

7 January 2021

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Antagonism of aminoacid transport in primary CD4 T cells by HIV-1 Vpu.

7 January 2021

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The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.

7 January 2021

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Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation

7 January 2021

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HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes

7 January 2021

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

7 January 2021

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Zebrafish germ cells: motility and guided migration

7 January 2021

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HIV-1 Nef-mediated inhibition of T cell migration and its molecular determinants.

7 January 2021

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HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

7 January 2021

1 reference

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Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity

7 January 2021

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Identification of the Nef-associated kinase as p21-activated kinase 2

7 January 2021

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Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

7 January 2021

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Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation

7 January 2021

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HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail

7 January 2021

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HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

7 January 2021

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Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2016.08.012

Interactions of the HIV/SIV pathogenicity factor Nef with SH3 domain-containing host cell proteins

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VIROL.2016.08.012

Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes

7 January 2021

1 reference

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HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2016.08.012

Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VIROL.2016.08.012

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

7 January 2021

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Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2016.08.012

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2016.08.012

HIV-1 Nef interferes with host cell motility by deregulation of Cofilin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2016.08.012

Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2016.08.012

Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors

7 January 2021

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SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

7 January 2021

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The many faces and functions of β-catenin

7 January 2021

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Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection

7 January 2021

1 reference

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HIV's Nef interacts with β-catenin of the Wnt signaling pathway in HEK293 cells

7 January 2021

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Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection

7 January 2021

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UCSF Chimera, MODELLER, and IMP: an integrated modeling system

7 January 2021

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HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2016.08.012

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

7 January 2021

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.VIROL.2016.08.012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27560372%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference