(Q38815318)

6 September 2017

title

Heat shock proteins as potential targets for protective strategies in neurodegeneration (English)

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6 September 2017

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1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27106072%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Steven Bergink

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27106072%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Harm H Kampinga

series ordinal

1

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6 September 2017

Steven Bergink

series ordinal

2

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6 September 2017

publication date

19 April 2016

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6 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27106072%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27106072%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27106072%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

748-759

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27106072%20AND%20SRC:MED&resulttype=core&format=json

Unfolding the role of protein misfolding in neurodegenerative diseases

4 June 2020

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7 January 2021

Heat shock proteins: therapeutic drug targets for chronic neurodegeneration?

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

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7 January 2021

Guidelines for the nomenclature of the human heat shock proteins

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7 January 2021

Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library

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7 January 2021

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

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7 January 2021

The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones

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7 January 2021

Molecular chaperones and protein quality control

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7 January 2021

A new puffing pattern induced by temperature shock and DNP in drosophila

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7 January 2021

Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs

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7 January 2021

Cellular strategies for controlling protein aggregation

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7 January 2021

State of play in amyotrophic lateral sclerosis genetics

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7 January 2021

Bridging the gap: from protein misfolding to protein misfolding diseases

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7 January 2021

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

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7 January 2021

Barcoding heat shock proteins to human diseases: looking beyond the heat shock response

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7 January 2021

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

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7 January 2021

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.

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7 January 2021

A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein

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7 January 2021

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.

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7 January 2021

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation

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7 January 2021

Cellular protein quality control and the evolution of aggregates in spinocerebellar ataxia type 3 (SCA3).

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7 January 2021

Polyglutamine aggregation in Huntington's disease and spinocerebellar ataxia type 3: similar mechanisms in aggregate formation

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7 January 2021

Levels of DNAJB family members (HSP40) correlate with disease onset in patients with spinocerebellar ataxia type 3.

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7 January 2021

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

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7 January 2021

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

β-hairpin-mediated nucleation of polyglutamine amyloid formation.

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7 January 2021

Protein folding and misfolding

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7 January 2021

The insulin paradox: aging, proteotoxicity and neurodegeneration

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7 January 2021

pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers

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7 January 2021

Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect

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7 January 2021

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

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7 January 2021

The amyloid state and its association with protein misfolding diseases.

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7 January 2021

From macroscopic measurements to microscopic mechanisms of protein aggregation

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7 January 2021

Chemical kinetics for drug discovery to combat protein aggregation diseases

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7 January 2021

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

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7 January 2021

Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis.

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7 January 2021

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

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7 January 2021

The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy

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7 January 2021

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

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7 January 2021

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

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7 January 2021

Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation.

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7 January 2021

Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity

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7 January 2021

Polyglutamine protein aggregates are dynamic

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7 January 2021

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

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7 January 2021

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

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7 January 2021

DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation

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https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

1 reference

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7 January 2021

The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol

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https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

DNAJs: more than substrate delivery to HSPA

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https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

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https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

Protein disaggregation mediated by heat-shock protein Hsp104.

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7 January 2021

Hsp104 and ClpB: protein disaggregating machines

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7 January 2021

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

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7 January 2021

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

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7 January 2021

Hsp104: a weapon to combat diverse neurodegenerative disorders.

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7 January 2021

Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease

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7 January 2021

The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system

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7 January 2021

Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans

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7 January 2021

Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils

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7 January 2021

Aggresomes: a cellular response to misfolded proteins

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7 January 2021

Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection

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7 January 2021

Misfolded proteins partition between two distinct quality control compartments

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7 January 2021

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition

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7 January 2021

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

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7 January 2021

Spatially organized aggregation of misfolded proteins as cellular stress defense strategy

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7 January 2021

Chaperone-mediated autophagy: a unique way to enter the lysosome world

1 reference

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7 January 2021

A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

1 reference

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7 January 2021

Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

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7 January 2021

Autophagic processes in yeast: mechanism, machinery and regulation

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7 January 2021

Potential therapeutic applications of autophagy

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7 January 2021

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones

1 reference

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7 January 2021

HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

A role for ubiquitin in selective autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

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https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch.

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7 January 2021

siRNA screen identifies QPCT as a druggable target for Huntington's disease

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7 January 2021

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition

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7 January 2021

Protein homeostasis as a therapeutic target for diseases of protein conformation

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7 January 2021

Hsp70 protein complexes as drug targets

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7 January 2021

A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases

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https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

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https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900099-5

7 January 2021

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

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7 January 2021

Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks

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7 January 2021

Pharmacological chaperone for α-crystallin partially restores transparency in cataract models

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7 January 2021

10.1016/S1474-4422(16)00099-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27106072%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference