(Q38857167)

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A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression

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7 September 2017

A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression (English)

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7 September 2017

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7 June 2020

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H Chen

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7 June 2020

B Lorton

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7 June 2020

V Gupta

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6 June 2016

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7 September 2017

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7 June 2020

36

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7 June 2020

373-386

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https://scigraph.springernature.com/pub.10.1038/onc.2016.205

0 references

Arginine methyltransferases in normal and malignant hematopoiesis

1 reference

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Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.

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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

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9 September 2017

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

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9 September 2017

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

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9 September 2017

CXCR7 mediates TGFβ1-promoted EMT and tumor-initiating features in lung cancer

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9 September 2017

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

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9 September 2017

Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer

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9 September 2017

Ski prevents TGF-β-induced EMT and cell invasion by repressing SMAD-dependent signaling in non-small cell lung cancer

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9 September 2017

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

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9 September 2017

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

1 reference

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9 September 2017

Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

1 reference

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9 September 2017

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

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9 September 2017

MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation

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9 September 2017

Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition

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9 September 2017

Molecular mechanisms of epithelial-mesenchymal transition

1 reference

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9 September 2017

Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

The epigenetics of epithelial-mesenchymal plasticity in cancer

1 reference

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9 September 2017

Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.

1 reference

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9 September 2017

Cancer development, progression, and therapy: an epigenetic overview.

1 reference

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9 September 2017

PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer

1 reference

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9 September 2017

Exploring TCGA Pan-Cancer data at the UCSC Cancer Genomics Browser

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9 September 2017

Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5.

1 reference

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9 September 2017

Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Metastasis suppressor genes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Overexpression of PRMT5 promotes tumor cell growth and is associated with poor disease prognosis in epithelial ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Protein arginine methyltransferases and cancer

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9 September 2017

The ConsensusPathDB interaction database: 2013 update

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9 September 2017

Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Chipster: user-friendly analysis software for microarray and other high-throughput data

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9 September 2017

REVIGO summarizes and visualizes long lists of gene ontology terms

1 reference

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Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression

1 reference

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9 September 2017

Histone arginine methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

1 reference

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9 September 2017

TGFbeta signalling: a complex web in cancer progression

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9 September 2017

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9 September 2017

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

PRMT5 is required for cell-cycle progression and p53 tumor suppressor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

1 reference

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9 September 2017

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

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9 September 2017

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9 September 2017

Analysis of histones in Xenopus laevis. II. mass spectrometry reveals an index of cell type-specific modifications on H3 and H4.

1 reference

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Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Metastasis suppressors genes in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

9 September 2017

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

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TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

1 reference

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Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes

1 reference

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9 September 2017

Discovery of a Dual PRMT5-PRMT7 Inhibitor

1 reference

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9 September 2017

HuR knockdown changes the oncogenic potential of oral cancer cells

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14 September 2017

The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation

1 reference

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14 September 2017

PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers

1 reference

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17 June 2018

Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion

1 reference

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17 June 2018

Suppression of SCARA5 by Snail1 is essential for EMT-associated cell migration of A549 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

22 August 2018

Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5140780

22 August 2018

The complex transcriptional landscape of the anucleate human platelet

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21 January 2018

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21 January 2018

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10.1038/ONC.2016.205

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27270440%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27270440%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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Europe PubMed Central

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7 June 2020

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