(Q38870753)

7 September 2017

HER2-mTOR signaling-driven breast cancer cells require ER-associated degradation to survive (English)

1 reference

7 September 2017

Navneet Singh

1

1 reference

PubMed ID

26012635

7 September 2017

Rashika Joshi

series ordinal

2

1 reference

PubMed ID

26012635

7 September 2017

Kakajan Komurov

series ordinal

3

1 reference

7 September 2017

26 May 2015

1 reference

7 September 2017

1 reference

7 September 2017

8

1 reference

7 September 2017

378

1 reference

7 September 2017

ra52

1 reference

Oncogene addiction: setting the stage for molecularly targeted cancer therapy

7 September 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Improving treatment of HER2-positive cancers: opportunities and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Cancer therapy based on oncogene addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Principles of cancer therapy: oncogene and non-oncogene addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Non-oncogene addiction and the stress phenotype of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Systematic identification of genomic markers of drug sensitivity in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Inconsistency in large pharmacogenomic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

International network of cancer genome projects

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

A comparative survey of functional footprints of EGFR pathway mutations in human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Comprehensive molecular portraits of human breast tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Oncogene-induced senescence as an initial barrier in lymphoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

NetWalker: a contextual network analysis tool for functional genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Cleaning up: ER-associated degradation to the rescue

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Defining human ERAD networks through an integrative mapping strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Inhibition of p97-dependent protein degradation by Eeyarestatin I

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

ER stress-induced cell death mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) displays a p-JNK-MAPK substrate preference in astrocytes in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Epidermal growth factor receptor targeting in cancer: a review of trends and strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Passenger deletions generate therapeutic vulnerabilities in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Cancer vulnerabilities unveiled by genomic loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

The role of the unfolded protein response in tumour development: friend or foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Targeting the unfolded protein response in disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAA6922

10.1126/SCISIGNAL.AAA6922

21 January 2018

Identifiers

DOI

1 reference

7 September 2017

1 reference

PubMed ID

26012635