(Q38925119)

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Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis

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scholarly article

1 reference

Europe PubMed Central

7 September 2017

Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis (English)

1 reference

Europe PubMed Central

7 September 2017

object named as

Petr Muller

8

0 references

Malcolm Walkinshaw

object named as

Malcolm Walkinshaw

7

0 references

Elizabeth Blackburn

6

object named as

Elizabeth Blackburn

1 reference

Europe PubMed Central

7 September 2017

author name string

Jennifer A Fraser

1

1 reference

Europe PubMed Central

7 September 2017

Erin G Worrall

2

1 reference

Europe PubMed Central

7 September 2017

Yao Lin

3

1 reference

Europe PubMed Central

7 September 2017

Vivien Landre

4

1 reference

Europe PubMed Central

7 September 2017

Susanne Pettersson

5

1 reference

Europe PubMed Central

7 September 2017

Borek Vojtesek

9

1 reference

Europe PubMed Central

7 September 2017

Kathryn Ball

10

1 reference

Europe PubMed Central

7 September 2017

Ted R Hupp

11

1 reference

Europe PubMed Central

7 September 2017

language of work or name

0 references

publication date

24 December 2014

1 reference

Europe PubMed Central

7 September 2017

number of pages

20

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based on heuristic

inferred from page(s)

Journal of Molecular Biology

1 reference

Europe PubMed Central

7 September 2017

427

1 reference

Europe PubMed Central

7 September 2017

8

1 reference

Europe PubMed Central

7 September 2017

1728-1747

1 reference

Europe PubMed Central

7 September 2017

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE11376

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

8 October 2022

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The central region of HDM2 provides a second binding site for p53.

1 reference

8 October 2022

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

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A function for the RING finger domain in the allosteric control of MDM2 conformation and activity

1 reference

8 October 2022

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Intrasteric regulation of MDM2.

1 reference

8 October 2022

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MDMX contains an autoinhibitory sequence element

1 reference

8 October 2022

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Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

1 reference

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The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

1 reference

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Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

1 reference

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Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway

1 reference

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Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein

1 reference

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Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

1 reference

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Mdm2 promotes the rapid degradation of p53

1 reference

8 October 2022

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Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells

1 reference

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Regulation of p53 stability by Mdm2

1 reference

8 October 2022

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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Attenuation of the p53 response to DNA damage by high cell density

1 reference

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Dual-site regulation of MDM2 E3-ubiquitin ligase activity

1 reference

8 October 2022

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Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo

1 reference

8 October 2022

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Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation

1 reference

8 October 2022

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Lipoic acid as a growth stimulant for Streptococcus faecalis in the presence of limiting quantities of isoleucine and valine

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8 October 2022

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

8 October 2022

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Autoactivation of the MDM2 E3 ligase by intramolecular interaction

1 reference

8 October 2022

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P53 mRNA controls p53 activity by managing Mdm2 functions

1 reference

8 October 2022

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An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

1 reference

8 October 2022

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Chemical states of the N-terminal "lid" of MDM2 regulate p53 binding: simulations reveal complexities of modulation

1 reference

8 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2014.12.011

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin

1 reference

8 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2014.12.011

A novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function

1 reference

8 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2014.12.011

Nanosensing protein allostery using a bivalent mouse double minute two (MDM2) assay

1 reference

8 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2014.12.011

Turning the RING domain protein MdmX into an active ubiquitin-protein ligase

1 reference

8 October 2022

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Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53

1 reference

8 October 2022

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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

1 reference

8 October 2022

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The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2.

1 reference

8 October 2022

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A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53

1 reference

8 October 2022

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On the mechanism of sequence-specific DNA-dependent acetylation of p53: the acetylation motif is exposed upon DNA binding

1 reference

8 October 2022

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Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo

1 reference

8 October 2022

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An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis.

1 reference

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Resumption of ovarian function in autumn lambing Dorset, Rambouillet and Finnish Landrace ewes

1 reference

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Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers

1 reference

8 October 2022

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Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression

1 reference

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Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro

1 reference

8 October 2022

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HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

1 reference

8 October 2022

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DNA-dependent acetylation of p53 by the transcription coactivator p300.

1 reference

8 October 2022

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Management of chemotherapy extravasation: ESMO--EONS clinical practice guidelines

1 reference

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Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

1 reference

8 October 2022

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Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif

1 reference

8 October 2022

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Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding

1 reference

8 October 2022

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10.1016/J.JMB.2014.12.011

1 reference

Europe PubMed Central

7 September 2017

1 reference

Europe PubMed Central

7 September 2017

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