(Q38957364)

8 September 2017

1 reference

title

Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment (English)

1 reference

G protein-coupled receptor

8 September 2017

main subject

0 references

author

Jose Vazquez-prado

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638873%20AND%20SRC:MED&resulttype=core&format=json

Rodolfo Daniel Cervantes-Villagrana

31 May 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638873%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Ismael Bracho-Valdés

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638873%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Guadalupe Reyes-Cruz

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638873%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

publication date

16 September 2016

1 reference

8 September 2017

published in

Molecular Pharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638873%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

90

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638873%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638873%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

573-586

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638873%20AND%20SRC:MED&resulttype=core&format=json

Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion

31 May 2020

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PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

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Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

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Molecular basis for interactions of G protein betagamma subunits with effectors

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Cancer invasion and the microenvironment: plasticity and reciprocity

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Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis

21 January 2018

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21 January 2018

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G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction

21 January 2018

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P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer

21 January 2018

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I'm coming to GEF you: Regulation of RhoGEFs during cell migration

21 January 2018

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21 January 2018

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21 January 2018

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Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

21 January 2018

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The disparate twins: a comparative study of CXCR4 and CXCR7 in SDF-1α-induced gene expression, invasion and chemosensitivity of colon cancer.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression

21 January 2018

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

21 January 2018

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Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases.

21 January 2018

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GPCR Signaling Mediates Tumor Metastasis via PI3Kβ

21 January 2018

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Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis

21 January 2018

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Immune cell promotion of metastasis

21 January 2018

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Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

21 January 2018

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Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13

21 January 2018

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21 January 2018

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Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families

21 January 2018

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Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release

21 January 2018

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21 January 2018

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21 January 2018

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G protein-coupled receptors: novel targets for drug discovery in cancer

21 January 2018

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Insights into the biological functions of Dock family guanine nucleotide exchange factors

21 January 2018

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Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor

21 January 2018

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21 January 2018

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21 January 2018

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Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

21 January 2018

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PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils

21 January 2018

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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

21 January 2018

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Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases

21 January 2018

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Biased signalling: the instinctive skill of the cell in the selection of appropriate signalling pathways

21 January 2018

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The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.

21 January 2018

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Spatial and Temporal Aspects of Signaling by G-Protein-Coupled Receptors

21 January 2018

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Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.

21 January 2018

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21 January 2018

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21 January 2018

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Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

21 January 2018

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Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4.

21 January 2018

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PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

21 January 2018

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Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.

21 January 2018

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Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity

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21 January 2018

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P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer.

21 January 2018

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Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

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Endosomes: a legitimate platform for the signaling train

21 January 2018

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Galphai is not required for chemotaxis mediated by Gi-coupled receptors

21 January 2018

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21 January 2018

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21 January 2018

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

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Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization

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The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.

21 January 2018

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Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration

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Calcium-sensing receptor inhibits TGF-β-signaling by decreasing Smad2 phosphorylation

21 January 2018

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

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Molecular pathways: P-Rex in cancer.

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

The metastatic niche: adapting the foreign soil

21 January 2018

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CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

Macrophage diversity enhances tumor progression and metastasis

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

Crystal structure of the β2 adrenergic receptor-Gs protein complex

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

Rho GTPase signalling in cell migration

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Cell migration: integrating signals from front to back

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

A family of G protein βγ subunits translocate reversibly from the plasma membrane to endomembranes on receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

Heterotrimeric G-protein betagamma-dimers in growth and differentiation

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105338

Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors

21 January 2018

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Improved culture-based isolation of differentiating endothelial progenitor cells from mouse bone marrow mononuclear cells

21 January 2018

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The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ.

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Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Essential role of Elmo1 in Dock2-dependent lymphocyte migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Gbetagamma inhibits Galpha GTPase-activating proteins by inhibition of Galpha-GTP binding during stimulation by receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Involvement of an autocrine stromal cell derived factor-1/CXCR4 system on the distant metastasis of human oral squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Domain-domain interaction of P-Rex1 is essential for the activation and inhibition by G protein betagamma subunits and PKA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Chemotaxis: signalling the way forward

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Mutations in GNA11 in uveal melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Whole genomes redefine the mutational landscape of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Regulation and function of P-Rex family Rac-GEFs

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Migratory neighbors and distant invaders: tumor-associated niche cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

X-ray structure of the mammalian GIRK2–βγ G-protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2-Gβ1γ2 Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

Blockade of the Stromal Cell–Derived Factor-1/CXCR4 Axis AttenuatesIn vivoTumor Growth by Inhibiting Angiogenesis in a Vascular Endothelial Growth Factor–Independent Manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105338

21 January 2018

Identifiers

DOI

10.1124/MOL.116.105338

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638873%20AND%20SRC:MED&resulttype=core&format=json

release_l3orfcaaprgzrbryrxku2nuxfy

31 May 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/l3orfcaaprgzrbryrxku2nuxfy

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference