(Q38991133)

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Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model.

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10 April 2020

Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model (English)

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10 April 2020

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Alzheimer's disease

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6

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10 April 2020

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10 April 2020

author name string

Zhong-Hao Zhang

1

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10 April 2020

Qiu-Yan Wu

2

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10 April 2020

Rui Zheng

3

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10 April 2020

Chen Chen

4

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10 April 2020

Yao Chen

5

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10 April 2020

Peter R Hoffmann

7

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10 April 2020

Jia-Zuan Ni

8

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10 April 2020

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30 January 2017

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10 April 2020

Journal of Neuroscience

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10 April 2020

37

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10 April 2020

9

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10 April 2020

2449-2462

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10 April 2020

TOR, a central controller of cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy as a regulated pathway of cellular degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development by self-digestion: molecular mechanisms and biological functions of autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P70 S6 kinase mediates tau phosphorylation and synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Role of serine/threonine protein phosphatase in tau phosphorylation]

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and Alzheimer disease: the autophagy connection?

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin D expression is decreased in Alzheimer's disease fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selenium level and cognitive function in rural elderly Chinese

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy fights disease through cellular self-digestion

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of tau in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selenium attenuates A beta production and A beta-induced neuronal death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methods in mammalian autophagy research

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Convergence of amyloid-beta and tau pathologies on mitochondria in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of tau kinases in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau reduction prevents Abeta-induced defects in axonal transport.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GSK3 and tau: two convergence points in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selenium level and depressive symptoms in a rural elderly Chinese cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble forms of tau are toxic in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selenite stimulates mitochondrial biogenesis signaling and enhances mitochondrial functional performance in murine hippocampal neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selenomethionine ameliorates cognitive decline, reduces tau hyperphosphorylation, and reverses synaptic deficit in the triple transgenic mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatase 2A dysfunction in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemic preconditioning provides neuroprotection by induction of AMP-activated protein kinase-dependent autophagy in a rat model of ischemic stroke.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect size of memory deficits in mice with adult-onset P301L tau expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The physiology and pathology of microtubule-associated protein tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 RNA interference improves spatial memory and attenuates Aβ burden in a streptozotocin-induced tau hyperphosphorylated rat model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-Dependent kinase 5 targeting prevents β-Amyloid aggregation involving glycogen synthase kinase 3β and phosphatases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox regulation of autophagy in healthy brain and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atorvastatin prevents Aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting Tau cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2015 Alzheimer's disease facts and figures

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of tau rescues inflammation-mediated neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TFEB Participates in the Aβ-Induced Pathogenesis of Alzheimer's Disease by Regulating the Autophagy-Lysosome Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Role of Oxidative Stress in Neurodegenerative Diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of proteasomes by lysosomes in rat liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered microtubule organization in small-calibre axons of mice lacking tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/28137967

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3229-16.2017

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28137967%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28137967%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28137967%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

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