(Q39024437)

8 September 2017

title

Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway (English)

1 reference

8 September 2017

0 references

1 reference

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24522518%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Ju-Xian Song

2

1 reference

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5 June 2020

Jiahong Lu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24522518%20AND%20SRC:MED&resulttype=core&format=json

Siva Sundara Kumar Durairajan

5 June 2020

6

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5 June 2020

5

Liang-Feng Liu

1 reference

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5 June 2020

author name string

Lei-Lei Chen

1

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5 June 2020

Zhen-Wei Yuan

4

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5 June 2020

publication date

13 February 2014

1 reference

Journal of Neuroimmune Pharmacology

8 September 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24522518%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

9

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5 June 2020

issue

3

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5 June 2020

page(s)

380-387

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Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.

5 June 2020

cites work

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Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

21 January 2018

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Epidemiology of Parkinson's disease

21 January 2018

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Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease.

21 January 2018

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Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages

21 January 2018

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mTOR regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-014-9528-2

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

21 January 2018

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

21 January 2018

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alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

21 January 2018

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Design and synthesis of novel furoquinoline based inhibitors of multiple targets in the PI3K/Akt-mTOR pathway

21 January 2018

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Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.

21 January 2018

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Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease

21 January 2018

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The role of chaperone-mediated autophagy in huntingtin degradation

21 January 2018

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Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

21 January 2018

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Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease

21 January 2018

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Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

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A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

21 January 2018

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Role and regulation of starvation-induced autophagy in the Drosophila fat body

21 January 2018

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

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Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats

21 January 2018

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Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

21 January 2018

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Uncaria rhynchophylla (miq) Jack plays a role in neuronal protection in kainic acid-treated rats

21 January 2018

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A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

21 January 2018

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

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Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

21 January 2018

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Autophagy contributes to caspase-independent macrophage cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-014-9528-2

Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-014-9528-2

Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-014-9528-2

Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism

21 January 2018

1 reference

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LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection

21 January 2018

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Targeting the mTOR kinase domain: the second generation of mTOR inhibitors

21 January 2018

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Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

21 January 2018

1 reference

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Clearance of mutant huntingtin

21 January 2018

1 reference

12 December 2020

1 reference

12 December 2020

Alpha-synuclein and Parkinson's disease

1 reference

12 December 2020

The role of autophagy in Parkinson's disease.

1 reference

12 December 2020

α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies

1 reference

12 December 2020

Treatment of idiopathic Parkinson's disease with traditional chinese herbal medicine: a randomized placebo-controlled pilot clinical study.

1 reference

12 December 2020

10.1007/S11481-014-9528-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24522518%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference