(Q39066287)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

title

Histone Lysine Demethylase Inhibitors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

author name string

Jamie N Anastas

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Yang Shi

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

publication date

3 January 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

Cold Spring Harbor Perspectives in Medicine

5 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

5 April 2020

cites work

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Genome-wide localization of small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Histone methylation: dynamic or static?

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1-CoREST Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

High-resolution profiling of histone methylations in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Oncogenic features of the JMJD2A histone demethylase in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibition of polyamine and spermine oxidases by polyamine analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Crystal structure of human histone lysine-specific demethylase 1 (LSD1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Structural basis of the recognition of a methylated histone tail by JMJD2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A mechanism-based inactivator for histone demethylase LSD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Antabuse's diamond anniversary: still sparkling on?

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Pesticides and food safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Monoamine oxidase inhibitors: Nature of their interaction with rabbit pancreatic islets to alter insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Suppression of invasion and metastasis of triple-negative breast cancer lines by pharmacological or genetic inhibition of slug activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Antihypertensive and monoamine oxidase inhibitory activity of some derivatives of 3-formyl-4-oxo-4H-pyrido (1,2-a) pyrimidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Novel Tranylcypromine/Hydroxylcinnamic Acid Hybrids as Lysine-Specific Demethylase 1 Inhibitors with Potent Antitumor Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibition of demethylases by GSK-J1/J4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphé tryptophan hydroxylase gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Histone lysine demethylases as targets for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Histone Demethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

p53 is regulated by the lysine demethylase LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Translating the Histone Code

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Histone H3 peptide based LSD1-selective inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A novel mammalian flavin-dependent histone demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Lysine methylation regulates E2F1-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Chromatin modifications and their function

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A histone H3 lysine 27 demethylase regulates animal posterior development

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

21 January 2018

The human flavoproteome

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Synthesis and biological evaluation of hybrids from farnesylthiosalicylic acid and hydroxylcinnamic acid with dual inhibitory activities of Ras-related signaling and phosphorylated NF-κB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Crystal structure of the nucleosome core particle at 2.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Design, synthesis, and structure-activity relationship of novel LSD1 inhibitors based on pyrimidine-thiourea hybrids as potent, orally active antitumor agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Advances in the development of histone lysine demethylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Molecular Pathways: At the Crossroads of Cancer Epigenetics and Immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

An high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

The diverse functions of histone lysine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

JmjC-domain containing histone demethylase 1B-mediated p15(Ink4b) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Brain-penetrant LSD1 inhibitors can block memory consolidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Identification of catechols as histone-lysine demethylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

The mechanism of action of the monoamine oxidase inhibitor pargyline

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Enzymatic demethylation of calf thymus histones

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A selective phenelzine analogue inhibitor of histone demethylase LSD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Glucocorticoid enhancement of memory storage involves noradrenergic activation in the basolateral amygdala

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A miniaturized screen for inhibitors of Jumonji histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

KDM1 is a novel therapeutic target for the treatment of gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Regulation of LSD1 histone demethylase activity by its associated factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Transcriptional regulation and multiple functions of MAO genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Nonsteroidal antiinflammatory drugs (second of two parts).

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Crystal structure and mechanism of human lysine-specific demethylase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Pyridinedicarboxylates, the first mechanism-derived inhibitors for prolyl 4-hydroxylase, selectively suppress cellular hydroxyprolyl biosynthesis. Decrease in interstitial collagen and Clq secretion in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Histone demethylation by a family of JmjC domain-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Identification of cell-active lysine specific demethylase 1-selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Overexpression of the shortest isoform of histone demethylase LSD1 primes hematopoietic stem cells for malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Opposing LSD1 complexes function in developmental gene activation and repression programmes

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Inhibition of LSD1 by Pargyline inhibited process of EMT and delayed progression of prostate cancer in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

The histone demethylase LSD1 is a novel oncogene and therapeutic target in oral cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Cryptotanshinone down-regulates androgen receptor signaling by modulating lysine-specific demethylase 1 function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FCSHPERSPECT.A026484

Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines

21 January 2018

1 reference

12 December 2020

Tranylcypromine in depression: a clinical report.

1 reference

12 December 2020

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).

1 reference

12 December 2020

Structure-based drug design: Opening the door to an epigenetic target

1 reference

12 December 2020

The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein

1 reference

12 December 2020

Natural Polyphenols Inhibit Lysine-Specific Demethylase-1 in vitro.

1 reference

12 December 2020

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

1 reference

12 December 2020

Epigenetic regulation and cancer (review).

1 reference

12 December 2020

Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential

1 reference

12 December 2020

Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors

1 reference

12 December 2020

Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer

1 reference

12 December 2020

GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells

1 reference

12 December 2020

Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.

1 reference

12 December 2020

Synthesis and biological evaluation of novel (E)-N'-(2,3-dihydro-1H-inden-1-ylidene) benzohydrazides as potent LSD1 inhibitors.

1 reference

12 December 2020

10.1101/CSHPERSPECT.A026484

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28049654%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

PubMed publication ID

28049654

1 reference