(Q39081836)

English

Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection

scientific article published on 2 October 2013

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

enantioselectivity

1 reference

based on heuristic

inferred from title

Carsten Strohmann

5

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Herbert Waldmann

8

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Andrey P. Antonchick

object named as

Andrey P Antonchick

7

0 references

Jonathan O Bauer

object named as

Jonathan O Bauer

4

0 references

object named as

Slava Ziegler

6

0 references

author name string

Hiroshi Takayama

1

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Zhi-Jun Jia

2

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Lea Kremer

3

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

language of work or name

0 references

publication date

2 October 2013

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Europe PubMed Central

PubMed publication ID

8 September 2017

Angewandte Chemie International Edition

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52

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

47

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

12404-12408

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

Synthesis of natural product inspired compound collections

1 reference

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Biology-inspired synthesis of compound libraries

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Bioactivity-guided navigation of chemical space

1 reference

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Biology-oriented synthesis

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The evolving role of natural products in drug discovery

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New aspects of natural products in drug discovery

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Natural products as sources of new drugs over the last 25 years

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The impact of natural products upon modern drug discovery.

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Natural products in drug discovery

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Drug discovery and natural products: end of an era or an endless frontier?

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Drug development from marine natural products

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Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

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Wnt/β-catenin signaling and disease

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Wnt/beta-catenin signaling: components, mechanisms, and diseases

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Wnt signalling and its impact on development and cancer

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Mining the Wnt pathway for cancer therapeutics

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The Wnt signaling pathway in development and disease

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Small molecules for stem cells

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In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction

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Wnt signalling in stem cells and cancer

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Effect of Wnt signaling pathway on wound healing

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Wnt signaling induces epithelial differentiation during cutaneous wound healing

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Beta-catenin in the race to fracture repair: in it to Wnt.

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The Hedgehog's tale: developing strategies for targeting cancer

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Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics

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New developments in the discovery of small molecule Hedgehog pathway antagonists

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Small-molecule modulators of the Sonic Hedgehog signaling pathway.

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Hedgehog-Gli signaling pathway inhibitors as anticancer agents.

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Modulators of the hedgehog signaling pathway

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Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

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A 1,536-well ultra-high-throughput siRNA screen to identify regulators of the Wnt/beta-catenin pathway

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A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

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Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

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Small molecule modulation of Smoothened activity

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A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model

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Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.

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Potent small molecule Hedgehog agonists induce VEGF expression in vitro

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Asymmetric synthesis of natural product inspired tricyclic benzopyrones by an organocatalyzed annulation reaction

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Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

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Discovery of neuritogenic compound classes inspired by natural products

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Naturally occurring iridoids, secoiridoids and their bioactivity. An updated review, part 3.

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Naturally occurring secoiridoids and bioactivity of naturally occurring iridoids and secoiridoids. A review, part 2.

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Naturally occurring iridoids. A review, part 1.

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Biological and pharmacological activity of naturally occurring iridoids and secoiridoids

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Biological and pharmacological activities of iridoids: recent developments

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Anti-inflammatory iridoids of botanical origin

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Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation.

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Identifiers

10.1002/ANIE.201306948

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

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