(Q39167898)

9 September 2017

title

Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells (English)

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9 September 2017

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Yu Zhu

1

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9 September 2017

Le Xu

2

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9 September 2017

Jianping Zhang

3

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9 September 2017

Xiaoyi Hu

4

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9 September 2017

Yujun Liu

5

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9 September 2017

Hankun Yin

6

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9 September 2017

Tao Lv

7

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9 September 2017

Heng Zhang

8

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9 September 2017

Li Liu

9

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9 September 2017

Huimin An

10

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9 September 2017

Haiou Liu

11

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9 September 2017

Jiejie Xu

12

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9 September 2017

Zongming Lin

13

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9 September 2017

publication date

16 May 2013

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9 September 2017

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9 September 2017

volume

104

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9 September 2017

issue

8

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9 September 2017

page(s)

1052-1061

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9 September 2017

cites work

Cancer statistics, 2012

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Renal cell carcinoma guideline

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What can molecular pathology contribute to the management of renal cell carcinoma?

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Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma

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Interferon alfa-2a versus combination therapy with interferon alfa-2a, interleukin-2, and fluorouracil in patients with untreated metastatic renal cell carcinoma (MRC RE04/EORTC GU 30012): an open-label randomised trial

21 January 2018

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Molecular basis for sunitinib efficacy and future clinical development

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Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells

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Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma

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Sunitinib versus interferon alfa in metastatic renal-cell carcinoma

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Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma

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Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma

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Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study

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Modes of resistance to anti-angiogenic therapy

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Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation

21 January 2018

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The BH3 mimetic ABT-737 induces cancer cell senescence.

21 January 2018

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A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

21 January 2018

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Inhibition of VEGF induces cellular senescence in colorectal cancer cells

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Senescence-messaging secretome: SMS-ing cellular stress

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Inflammatory networks during cellular senescence: causes and consequences

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Cellular senescence: putting the paradoxes in perspective

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

1 reference

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors

21 January 2018

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Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation

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Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization.

21 January 2018

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Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component

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Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway

21 January 2018

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Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage

21 January 2018

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Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1

21 January 2018

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DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence

21 January 2018

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8-oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts

21 January 2018

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

21 January 2018

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Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

21 January 2018

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Treatment of metastatic renal cell carcinoma.

21 January 2018

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Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex

21 January 2018

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Evidence that exposure of the telomere 3' overhang sequence induces senescence

21 January 2018

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Sunitinib in patients with metastatic renal cell carcinoma

21 January 2018

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Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance.

21 January 2018

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p53 pathway in renal cell carcinoma is repressed by a dominant mechanism.

21 January 2018

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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

21 January 2018

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Pro-senescence therapy for cancer treatment

21 January 2018

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Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations

21 January 2018

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A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23578198

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/CAS.12176

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9 September 2017

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