(Q39234405)

10 September 2017

title

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease (English)

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10 September 2017

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9

Bart De Strooper

1 reference

10 September 2017

Amantha Thathiah

1

1 reference

10 September 2017

Katrien Horré

2

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10 September 2017

An Snellinx

3

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10 September 2017

Elke Vandewyer

4

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10 September 2017

Yunhong Huang

5

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10 September 2017

Marta Ciesielska

6

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10 September 2017

Gerdien De Kloe

7

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10 September 2017

Sebastian Munck

8

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10 September 2017

language of work or name

English

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publication date

2 December 2012

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10 September 2017

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10 September 2017

volume

19

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10 September 2017

issue

1

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10 September 2017

page(s)

43-49

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https://scigraph.springernature.com/pub.10.1038/nm.3023

10 September 2017

exact match

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cites work

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

Tau-targeted treatment strategies in Alzheimer's disease

21 January 2018

1 reference

Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift

21 January 2018

1 reference

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

21 January 2018

1 reference

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

21 January 2018

1 reference

Resolving controversies on the path to Alzheimer's therapeutics

21 January 2018

1 reference

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

The genetics of Alzheimer disease: back to the future

21 January 2018

1 reference

Genetics of Alzheimer disease

21 January 2018

1 reference

APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

21 January 2018

1 reference

The repertoire of G-protein-coupled receptors in fully sequenced genomes

21 January 2018

1 reference

Receptors and G proteins as primary components of transmembrane signal transduction. Part 1. G-protein-coupled receptors: structure and function.

21 January 2018

1 reference

The G protein-coupled receptor repertoires of human and mouse

21 January 2018

1 reference

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

21 January 2018

1 reference

Beta-arrestins and cell signaling

21 January 2018

1 reference

Therapeutic potential of β-arrestin- and G protein-biased agonists.

21 January 2018

1 reference

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

21 January 2018

1 reference

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

21 January 2018

1 reference

A beta-arrestin 2 signaling complex mediates lithium action on behavior

21 January 2018

1 reference

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation

21 January 2018

1 reference

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization

21 January 2018

1 reference

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors

21 January 2018

1 reference

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

21 January 2018

1 reference

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

21 January 2018

1 reference

The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons

21 January 2018

1 reference

Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

21 January 2018

1 reference

A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.

21 January 2018

1 reference

Beta galactosidase complementation: a cell-based luminescent assay platform for drug discovery

21 January 2018

1 reference

The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling

21 January 2018

1 reference

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor

21 January 2018

1 reference

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

21 January 2018

1 reference

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice

21 January 2018

1 reference

G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there?

21 January 2018

1 reference

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

21 January 2018

1 reference

Gamma-secretase activity is present in rafts but is not cholesterol-dependent

21 January 2018

1 reference

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

1 reference

Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains

21 January 2018

1 reference

Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors

21 January 2018

1 reference

Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase

21 January 2018

1 reference

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

21 January 2018

1 reference

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

1 reference

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

21 January 2018

1 reference

The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner

21 January 2018

1 reference

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

21 January 2018

1 reference

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

21 January 2018

1 reference

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

Neuropathological stageing of Alzheimer-related changes

21 January 2018

1 reference

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

21 January 2018

1 reference

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

21 January 2018

1 reference

Enhanced morphine analgesia in mice lacking beta-arrestin 2

21 January 2018

2 references

PubMed

https://pubmed.ncbi.nlm.nih.gov/23202293

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

inferred from DOI database lookup

7 January 2021

based on heuristic

Mapping the road forward in Alzheimer's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23202293

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NM.3023

1 reference

Dimensions Publication ID

10 September 2017

1006374095

0 references

1 reference