(Q34604101)

3 August 2017

title

Genetics of Alzheimer disease (English)

1 reference

3 August 2017

0 references

Debby W Tsuang

4

0 references

author name string

Lynn M Bekris

series ordinal

1

1 reference

3 August 2017

Chang-En Yu

series ordinal

2

1 reference

3 August 2017

Thomas D Bird

series ordinal

3

1 reference

3 August 2017

publication date

1 December 2010

1 reference

Journal of Geriatric Psychiatry and Neurology

3 August 2017

published in

1 reference

3 August 2017

volume

23

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3 August 2017

issue

4

1 reference

3 August 2017

page(s)

213-227

1 reference

A novel presenilin 2 mutation (V393M) in early-onset dementia with profound language impairment.

3 August 2017

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7 July 2018

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7 July 2018

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Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline

7 July 2018

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Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials

7 July 2018

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When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

7 July 2018

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Alzheimer's disease and cholesterol: the fat connection

7 July 2018

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A century of Alzheimer's disease

7 July 2018

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Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies.

7 July 2018

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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

7 July 2018

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Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

7 July 2018

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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

7 July 2018

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The development of amyloid beta protein deposits in the aged brain.

7 July 2018

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7 July 2018

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Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

7 July 2018

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Global prevalence of dementia: a Delphi consensus study

7 July 2018

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Genes involved in Alzheimer's disease, a survey of possible candidates

7 July 2018

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Emerging prospects for the disease-modifying treatment of Alzheimer's disease

7 July 2018

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The current status of Alzheimer's disease genetics: what do we tell the patients?

7 July 2018

1 reference

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Molecular pathways to neurodegeneration

7 July 2018

1 reference

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Molecular genetics of late-onset Alzheimer's disease.

7 July 2018

1 reference

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Meat-adaptive genes and the evolution of slower aging in humans

7 July 2018

1 reference

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Alzheimer's disease: one disorder, too many genes?

7 July 2018

1 reference

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Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

7 July 2018

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7 July 2018

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A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

21 January 2018

1 reference

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Transgenic mouse models of Alzheimer's disease: phenotype and application

7 July 2018

1 reference

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Clinical practice. Early Alzheimer's disease

7 July 2018

1 reference

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Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

7 July 2018

1 reference

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

7 July 2018

1 reference

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Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

7 July 2018

1 reference

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Alzheimer's disease and Parkinson's disease

7 July 2018

1 reference

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The role of presenilin cofactors in the gamma-secretase complex

7 July 2018

1 reference

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Epidemiology of neurodegeneration

7 July 2018

1 reference

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7 July 2018

1 reference

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The genetic causes of neurodegenerative diseases

7 July 2018

1 reference

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

7 July 2018

1 reference

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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Genetic and host factors for dementia in Down's syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Alzheimer's disease and other dementias: a review

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Risk of dementia among white and African American relatives of patients with Alzheimer disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

A portrait of Alzheimer secretases--new features and familiar faces

7 July 2018

1 reference

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Alzheimer's disease: genes, proteins, and therapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes.

7 July 2018

1 reference

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Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice.

7 July 2018

1 reference

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Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression

7 July 2018

1 reference

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The number of trait loci in late-onset Alzheimer disease

7 July 2018

1 reference

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Is epsilon4 the ancestral human apoE allele?

7 July 2018

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The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based case series

7 July 2018

1 reference

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Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.

7 July 2018

1 reference

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

7 July 2018

1 reference

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Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum

7 July 2018

1 reference

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Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

7 July 2018

1 reference

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Specific regional transcription of apolipoprotein E in human brain neurons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Frequency of stages of Alzheimer-related lesions in different age categories

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

The presenilins and Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Skeletal and CNS defects in Presenilin-1-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Altered apolipoprotein E secretion in cytokine treated human astrocyte cultures

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Apolipoprotein E: risk factor for Alzheimer disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

A familial Alzheimer's disease locus on chromosome 1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Genetic dissection of Alzheimer disease, a heterogeneous disorder

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

The amyloid deposits in Alzheimer's disease: their nature and pathogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

High molecular weight microtubule-associated proteins: purification by electro-elution and amino acid compositions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Immunocytochemical profile of neurofibrillary tangles in Down's syndrome patients of different ages

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

APP-695 transcript prevalence is selectively reduced during Alzheimer's disease in cortex and hippocampus but not in cerebellum.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Expression of apolipoprotein E during nerve degeneration and regeneration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Genomic organization of the human amyloid beta-protein precursor gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Alternative splicing of the βA4 amyloid gene of Alzheimer's disease in cortex of control and Alzheimer's disease patients

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Neuropathological stageing of Alzheimer-related changes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Familial Alzheimer's disease: second gene locus located

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Dementia and Alzheimer disease incidence: a prospective cohort study.

7 July 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Early-onset Alzheimer disease in families with late-onset Alzheimer disease: a potential important subtype of familial Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Alzheimer's disease. Closing in on gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Apolipoprotein E E4 allele and risk of dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Genetics. Once shunned, test for Alzheimer's risk headed to market.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Early onset familial Alzheimer's disease: Mutation frequency in 31 families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Molecular diagnosis of autosomal dominant early onset Alzheimer's disease: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Abeta-42 deposition precedes other changes in PS-1 Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Apolipoprotein E polymorphism and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Apolipoprotein E-epsilon 4 allele doses in late-onset Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Apolipoprotein E genotype in patients with alzheimer's disease: Implications for the risk of dementia among relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

ApoE immunoreactivity and microglial cells in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

APOE alleles predict the rate of cognitive decline in Alzheimer disease: a nonlinear model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Patterns of risk in first-degree relatives of patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Conjugal Alzheimer disease: risk in children when both parents have Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Genetic testing has no place as a routine diagnostic test in sporadic and familial cases of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

Recent advances in the genetics of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0891988710383571

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Apolipoprotein E polymorphism and acute ischemic stroke: a diffusion- and perfusion-weighted magnetic resonance imaging study

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Molecular analysis of the presenilin 1 (S182) gene in "sporadic" cases of Alzheimer's disease: identification and characterisation of unusual splice variants

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044597

Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease

26 October 2018

1 reference

12 December 2020

Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40

1 reference

12 December 2020

Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

1 reference

12 December 2020

Diagnostic challenges in dementia

1 reference

12 December 2020

Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis

1 reference

12 December 2020

Expression of apolipoprotein E in ballooned neurons-comparative immunohistochemical study on neurodegenerative disorders and infarction

1 reference

12 December 2020

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

1 reference

12 December 2020

The genetics of Alzheimer's disease

1 reference

12 December 2020

Alzheimer's APP mangles mitochondria

1 reference

12 December 2020

Three types of amyloid protein precursor mRNA in human brain: their differential expression in Alzheimer's disease

1 reference

12 December 2020

Structure and alternative splicing of the presenilin-2 gene

1 reference

12 December 2020

Apolipoprotein E expression by neurons surviving excitotoxic stress

1 reference

12 December 2020

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

1 reference

12 December 2020

Molecular genetics of Alzheimer's disease

1 reference

12 December 2020

Identifiers

DOI

10.1177/0891988710383571

1 reference

3 August 2017

1 reference

3 August 2017

1 reference