(Q39241528)

English

Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy

scientific article published on 20 November 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy (English)

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

0 references

endoplasmic reticulum

0 references

Hepatitis C virus

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

He Huang

1

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Rongyan Kang

2

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Ji Wang

3

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Guangxiang Luo

4

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Wei Yang

5

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Zhendong Zhao

6

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

publication date

20 November 2012

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

9

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

175-195

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling.

1 reference

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Replication of hepatitis C virus RNA on autophagosomal membranes

1 reference

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Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation

1 reference

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Virus-triggered autophagy in viral hepatitis - possible novel strategies for drug development

1 reference

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Survival and death of endoplasmic-reticulum-stressed cells: Role of autophagy

1 reference

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HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response

1 reference

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

1 reference

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1 reference

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Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis.

1 reference

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Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK.

1 reference

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Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes

1 reference

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10 September 2017

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

1 reference

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10 September 2017

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

1 reference

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10 September 2017

Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

The association of AMPK with ULK1 regulates autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection

1 reference

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10 September 2017

Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

mTOR regulation of autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics

1 reference

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10 September 2017

Hepatitis C Virus Infection in Phenotypically Distinct Huh7 Cell Lines

1 reference

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10 September 2017

The autophagy machinery is required to initiate hepatitis C virus replication

1 reference

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10 September 2017

New and experimental therapies for HCV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

Hepatitis C Virus Nonstructural 4B Protein Modulates Sterol Regulatory Element-binding Protein Signaling via the AKT Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

A complex interplay between Akt, TSC2 and the two mTOR complexes

1 reference

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Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system

1 reference

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10 September 2017

Hepatitis C infection and risk of diabetes: a systematic review and meta-analysis

1 reference

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10 September 2017

AMPK: a key regulator of energy balance in the single cell and the whole organism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

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Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response

1 reference

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Perturbation of autophagic pathway by hepatitis C virus

1 reference

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Role of platelet-derived growth factors in physiology and medicine

1 reference

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10 September 2017

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

AMPK phosphorylation of raptor mediates a metabolic checkpoint

1 reference

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Autophagy fights disease through cellular self-digestion

1 reference

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Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance

1 reference

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Hepatitis C Virus Genotype 1a Growth and Induction of Autophagy

1 reference

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10 September 2017

Autophagy: process and function

1 reference

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Self-eating and self-killing: crosstalk between autophagy and apoptosis

1 reference

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AKT/PKB signaling: navigating downstream

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

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Signal integration in the endoplasmic reticulum unfolded protein response

1 reference

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Replication of hepatitis C virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552882

10 September 2017

Endoplasmic reticulum stress triggers autophagy

1 reference

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Role of the unfolded protein response in cell death

1 reference

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10 September 2017

AKT crystal structure and AKT-specific inhibitors

1 reference

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Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells

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Global epidemiology of hepatitis C virus infection

1 reference

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10 September 2017

Activation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replication

1 reference

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Robust hepatitis C virus infection in vitro

1 reference

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1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

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Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

1 reference

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Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication

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10 September 2017

Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

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The protein kinase B/Akt signalling pathway in human malignancy

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Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells

1 reference

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Role of AMP-activated protein kinase in mechanism of metformin action

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10 September 2017

Hepatitis C virus infection

1 reference

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Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis

1 reference

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Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations

1 reference

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Inhibition of hepatitis C virus replication through adenosine monophosphate-activated protein kinase-dependent and -independent pathways

1 reference

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Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes

1 reference

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14 September 2017

Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy.

1 reference

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14 September 2017

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1 reference

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Transcriptional regulation by cyclic AMP.

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15 June 2018

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21 August 2018

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1 reference

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21 August 2018

The Akt isoforms are present at distinct subcellular locations

1 reference

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21 August 2018

Autophagy proteins promote hepatitis C virus replication

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21 August 2018

Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta-analysis

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21 August 2018

AMPK and Raptor: matching cell growth to energy supply.

1 reference

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21 August 2018

Hepatitis C virus and risk of lymphoma and other lymphoid neoplasms: a meta-analysis of epidemiologic studies

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21 August 2018

ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

1 reference

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21 August 2018

5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.

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21 August 2018

Upregulation of renal BSC1 and TSC in prenatally programmed hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/23169238

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.4161/AUTO.22791

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

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