(Q39298005)

10 September 2017

RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex (English)

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10 September 2017

6

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10 September 2017

R Kappler

3

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author name string

B A Abhari

1

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10 September 2017

S Cristofanon

2

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10 September 2017

D von Schweinitz

4

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10 September 2017

R Humphreys

5

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10 September 2017

language of work or name

English

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publication date

13 August 2012

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10 September 2017

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32

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27

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10 September 2017

3263-3273

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https://scigraph.springernature.com/pub.10.1038/onc.2012.337

10 September 2017

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cites work

Hallmarks of Cancer: The Next Generation

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https://api.crossref.org/works/10.1038%2FONC.2012.337

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

21 January 2018

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Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

21 January 2018

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Targeting mitochondria for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.337

Tumor resistance to apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.337

IAP-targeted therapies for cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.337

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Targeting IAPs as an approach to anti-cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Initial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing Program

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.337

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.337

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.337

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.337

TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Down-regulation of RIP expression by 17-dimethylaminoethylamino-17-demethoxygeldanamycin promotes TRAIL-induced apoptosis in breast tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.337

RIP1, a kinase on the crossroads of a cell's decision to live or die

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.337

Molecular mechanisms of necroptosis: an ordered cellular explosion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Trail receptors: targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.337

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.337

1 reference

10 September 2017

1 reference