(Q39450922)

12 September 2017

Ku regulates signaling to DNA damage response pathways through the Ku70 von Willebrand A domain (English)

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12 September 2017

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Victoria L Fell

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12 September 2017

Caroline Schild-Poulter

series ordinal

2

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12 September 2017

language of work or name

English

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publication date

28 October 2011

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Molecular and Cellular Biology

12 September 2017

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12 September 2017

32

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12 September 2017

1

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12 September 2017

76-87

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describes a project that uses

12 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3255697/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

12 September 2017

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Inhibition of Id proteins by a peptide aptamer induces cell-cycle arrest and apoptosis in ovarian cancer cells

12 September 2017

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Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways

12 September 2017

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Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends

12 September 2017

1 reference

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

12 September 2017

1 reference

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Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response

12 September 2017

1 reference

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Emerging roles of ATF2 and the dynamic AP1 network in cancer

12 September 2017

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Mechanisms of double-strand break repair in somatic mammalian cells

12 September 2017

1 reference

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ATF3 transcription factor and its emerging roles in immunity and cancer

12 September 2017

1 reference

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DeubiKuitylation: a novel DUB enzymatic activity for the DNA repair protein, Ku70.

12 September 2017

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Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis

12 September 2017

1 reference

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Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

12 September 2017

1 reference

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DNA-PK: the means to justify the ends?

12 September 2017

1 reference

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Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

12 September 2017

1 reference

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Early events in the mammalian response to DNA double-strand breaks

12 September 2017

1 reference

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

12 September 2017

1 reference

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Regulation of the cellular DNA double-strand break response

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

NetworKIN: a resource for exploring cellular phosphorylation networks

12 September 2017

1 reference

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ATF2 on the double - activating transcription factor and DNA damage response protein

12 September 2017

1 reference

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ATM activation and DNA damage response

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

DNA double-strand break repair: from mechanistic understanding to cancer treatment

12 September 2017

1 reference

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DNA damage-induced cell death by apoptosis.

12 September 2017

1 reference

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The role of the nonhomologous end-joining DNA double-strand break repair pathway in telomere biology

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Cellular responses to DNA damage: one signal, multiple choices

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

DNA double-strand break repair: a relentless hunt uncovers new prey.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Coping with stress: eIF2 kinases and translational control

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Id family of helix-loop-helix proteins in cancer

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

The life and death of DNA-PK.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Double-strand breaks: signaling pathways and repair mechanisms.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

H2AX: the histone guardian of the genome

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

A means to a DNA end: the many roles of Ku.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

DNA damage-induced apoptosis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

MUSCLE: multiple sequence alignment with high accuracy and high throughput

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR)

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Mechanism and regulation of human non-homologous DNA end-joining

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Regulation and mechanisms of mammalian double-strand break repair

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Pathways of DNA double-strand break repair during the mammalian cell cycle

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Id proteins in development, cell cycle and cancer

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Modelling the molecular circuitry of cancer

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

SAP - a putative DNA-binding motif involved in chromosomal organization

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

The DNA-dependent protein kinase

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Ku70: a candidate tumor suppressor gene for murine T cell lymphoma

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Down-regulation of inhibition of differentiation-1 via activation of activating transcription factor 3 and Smad regulates REIC/Dickkopf-3-induced apoptosis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255697

DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer

21 August 2018

1 reference

12 December 2020

The scid mutation in mice causes a general defect in DNA repair

1 reference

12 December 2020

Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions

1 reference

12 December 2020

A backup DNA repair pathway moves to the forefront

1 reference

12 December 2020

Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway

1 reference

12 December 2020

Nuclear localization of Ku antigen is promoted independently by basic motifs in the Ku70 and Ku80 subunits

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.05661-11

1 reference

12 September 2017

1 reference

12 September 2017

PubMed publication ID

22037767

1 reference