(Q39669709)

13 September 2017

title

Hypoxia-inducible factors: post-translational crosstalk of signaling pathways (English)

1 reference

13 September 2017

Hypoxia-Inducible Factors: Post-translational Crosstalk of Signaling Pathways (English)

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

18 June 2024

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694670

post-translational protein modification

18 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694670

18 June 2024

2

Thomas Kietzmann

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694670

18 June 2024

author name string

Elitsa Y. Dimova

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694670

18 June 2024

language of work or name

English

0 references

publication date

1 January 2010

1 reference

full work available at URL

13 September 2017

http://link.springer.com/content/pdf/10.1007/978-1-60761-738-9_13

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Methods in Molecular Biology

18 June 2024

published in

1 reference

13 September 2017

volume

647

1 reference

13 September 2017

page(s)

215-236

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

13 September 2017

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

The mammalian basic helix-loop-helix/PAS family of transcriptional regulators

1

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site

18 June 2024

2

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Integration of oxygen signaling at the consensus HRE.

18 June 2024

3

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

18 June 2024

Life with oxygen

4

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

18 June 2024

5

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

18 June 2024

6

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

18 June 2024

7

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Identification and characterization of a nuclease specific for the 3' end of the U6 small nuclear RNA

18 June 2024

8

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

18 June 2024

9

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

18 June 2024

10

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions

18 June 2024

11

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene

18 June 2024

12

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

18 June 2024

14

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

18 June 2024

15

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

18 June 2024

16

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

18 June 2024

17

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

18 June 2024

18

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin

18 June 2024

19

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

18 June 2024

20

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

18 June 2024

21

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

18 June 2024

23

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

18 June 2024

24

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

18 June 2024

25

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Turn me on: regulating HIF transcriptional activity.

18 June 2024

26

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

18 June 2024

27

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

18 June 2024

28

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

18 June 2024

29

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

18 June 2024

30

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver

18 June 2024

32

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha

18 June 2024

33

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

18 June 2024

34

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

18 June 2024

35

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells

18 June 2024

36

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex

18 June 2024

37

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions

18 June 2024

38

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Expression of hypoxia-inducible factor-1 in the cochlea of newborn rats.

18 June 2024

39

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Hypoxia rapidly activates HIF-3alpha mRNA expression

18 June 2024

40

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem

18 June 2024

41

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

18 June 2024

42

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

How oxygen makes its presence felt

18 June 2024

43

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Oxygen sensing by HIF hydroxylases

18 June 2024

44

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

HIF hydroxylation and the mammalian oxygen-sensing pathway

18 June 2024

45

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

A conserved family of prolyl-4-hydroxylases that modify HIF

18 June 2024

46

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

18 June 2024

47

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

18 June 2024

48

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

18 June 2024

49

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

18 June 2024

50

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha

18 June 2024

51

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

18 June 2024

52

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

18 June 2024

53

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

18 June 2024

55

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

18 June 2024

56

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

18 June 2024

57

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

18 June 2024

58

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

18 June 2024

59

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Jab1 interacts directly with HIF-1alpha and regulates its stability

18 June 2024

61

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

18 June 2024

62

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

18 June 2024

63

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

18 June 2024

64

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

18 June 2024

65

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

18 June 2024

66

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha

18 June 2024

67

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF

18 June 2024

68

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

ARDent about acetylation and deacetylation in hypoxia signalling.

18 June 2024

69

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Signal transduction to hypoxia-inducible factor 1

18 June 2024

70

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

18 June 2024

71

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.

18 June 2024

72

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation

18 June 2024

73

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

18 June 2024

74

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha

18 June 2024

75

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Transcriptional regulation of plasminogen activator inhibitor-1 expression by insulin-like growth factor-1 via MAP kinases and hypoxia-inducible factor-1 in HepG2 cells

18 June 2024

77

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia

18 June 2024

78

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha.

18 June 2024

79

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity

18 June 2024

80

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK.

18 June 2024

81

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

18 June 2024

85

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner

18 June 2024

86

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression

18 June 2024

87

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

18 June 2024

88

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells

18 June 2024

89

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide

18 June 2024

91

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases

18 June 2024

92

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

18 June 2024

93

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

HIF-1 alpha protein as a target for S-nitrosation

18 June 2024

94

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha

18 June 2024

95

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Regulation of HIF-1alpha stability through S-nitrosylation

18 June 2024

96

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Sumoylation increases HIF-1alpha stability and its transcriptional activity

18 June 2024

97

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia

18 June 2024

98

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity.

18 June 2024

99

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia

18 June 2024

100

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues

18 June 2024

101

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

10 Posttranslational enzymes in the biosynthesis of collagen: Intracellular enzymes

18 June 2024

102

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

18 June 2024

103

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development

18 June 2024

104

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression

18 June 2024

105

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1.

18 June 2024

106

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

18 June 2024

107

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

A new technique for the assay of infectivity of human adenovirus 5 DNA

18 June 2024

108

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-738-9_13

18 June 2024

Identifiers

1 reference

13 September 2017

1 reference