(Q39770080)

English

Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

breast neoplasm

1 reference

based on heuristic

inferred from title

Abelardo López-Rivas

3

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

author name string

T Sánchez-Pérez

1

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

G Ortiz-Ferrón

2

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

publication date

27 November 2009

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Cell Death & Differentiation

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Europe PubMed Central

PubMed publication ID

14 September 2017

17

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

883-894

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

https://scigraph.springernature.com/pub.10.1038/cdd.2009.176

0 references

Death receptors: signaling and modulation

1 reference

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Safety and antitumor activity of recombinant soluble Apo2 ligand

1 reference

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Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

1 reference

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Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

1 reference

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21 January 2018

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

1 reference

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21 January 2018

Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway

1 reference

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21 January 2018

Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells

1 reference

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21 January 2018

Mitochondria-dependent and -independent mechanisms in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis are both regulated by interferon-gamma in human breast tumour cells.

1 reference

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21 January 2018

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

1 reference

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21 January 2018

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Inhibition of death receptor signals by cellular FLIP

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

1 reference

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21 January 2018

NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

The spindle assembly checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Coupling cell division and cell death to microtubule dynamics

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Microtubules, microtubule-interfering agents and apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.

1 reference

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21 January 2018

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

JNK/SAPK activity contributes to TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

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21 January 2018

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Ablation of the spindle assembly checkpoint by a compound targeting Mps1.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Timing and checkpoints in the regulation of mitotic progression

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

1 reference

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21 January 2018

The TRAIL apoptotic pathway in cancer onset, progression and therapy

1 reference

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21 January 2018

Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins

1 reference

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21 January 2018

Erythroid differentiation sensitizes K562 leukemia cells to TRAIL-induced apoptosis by downregulation of c-FLIP.

1 reference

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21 January 2018

An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis

1 reference

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Down-regulation of c-FLIP contributes to the sensitization effect of 3,3'-diindolylmethane on TRAIL-induced apoptosis in cancer cells.

1 reference

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21 January 2018

MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton.

1 reference

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Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells.

1 reference

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Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.

1 reference

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21 January 2018

Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.

1 reference

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21 January 2018

The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation

1 reference

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21 January 2018

TRAIL inactivates the mitotic checkpoint and potentiates death induced by microtubule-targeting agents in human cancer cells.

1 reference

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21 January 2018

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

1 reference

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Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

1 reference

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Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells

1 reference

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Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1 reference

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Phosphorylation of FADD is critical for sensitivity to anticancer drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Modulation of tumor necrosis factor apoptosis-inducing ligand- induced NF-kappa B activation by inhibition of apical caspases

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.176

21 January 2018

Role of cell shape in growth control

1 reference

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21 January 2018

Microtubule dynamics: mechanism, regulation, and function.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Unraveling MCL-1 degradation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/CDD.2009.176

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

ResearchGate publication ID

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