(Q39809409)

English

The role of permeability in drug ADME/PK, interactions and toxicity--presentation of a permeability-based classification system (PCS) for prediction of ADME/PK in humans

scientific article published on 21 August 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

The role of permeability in drug ADME/PK, interactions and toxicity--presentation of a permeability-based classification system (PCS) for prediction of ADME/PK in humans (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

author name string

Urban Fagerholm

1

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

21 August 2007

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

25

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

625-638

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Pharmacokinetic evaluation in man of terbutaline given as separate enantiomers and as the racemate

1 reference

https://api.crossref.org/works/10.1007%2FS11095-007-9397-Y

21 January 2018

The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system

1 reference

https://api.crossref.org/works/10.1007%2FS11095-007-9397-Y

21 January 2018

Human jejunal effective permeability and its correlation with preclinical drug absorption models

1 reference

https://api.crossref.org/works/10.1007%2FS11095-007-9397-Y

21 January 2018

Prediction of brain delivery of ofloxacin, a new quinolone, in the human from animal data

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

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Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation and suggested improvements of the Biopharmaceutics Classification System (BCS).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of oral absorption and bioavailablity of drugs between monkey and human

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A physiological model for the estimation of the fraction dose absorbed in humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterohepatic circulation: physiological, pharmacokinetic and clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In silico predictions of blood-brain barrier penetration: considerations to "keep in mind".

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug delivery across the blood-brain barrier: why is it difficult? how to measure and improve it?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of the volumes of distribution of basic drugs in humans based on data from animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The blood-brain barrier: bottleneck in brain drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms and clinical implications of renal drug excretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional intestinal permeability in rats of compounds with different physicochemical properties and transport mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport screening of drug cocktails through an in vitro blood-brain barrier: is it a good strategy for increasing the throughput of the discovery pipeline?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transporters and drug therapy: implications for drug disposition and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-brain barrier permeation: molecular parameters governing passive diffusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functional role of P-glycoprotein in the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human pharmacokinetics--gastrointestinal absorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The disposition of aspirin and salicylic acid in the isolated perfused rat liver: the effect of normal and retrograde flow on availability and mean transit time

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased drug delivery to the brain by P-glycoprotein inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Water and nonelectrolyte permeability of isolated rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transporter-mediated permeation of drugs across the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Jejunal absorption and metabolism of R/S-verapamil in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods, and normal morphometric data for rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First-pass metabolism of midazolam by the human intestine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Jejunal permeability in humans in vivo and rats in situ: investigation of molecular size selectivity and solvent drag

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of fluids from the stomach and proximal jejunum in men and women.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist, CTAP: comparison with morphine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new diffusion chamber system for the determination of drug permeability coefficients across the human intestinal epithelium that are independent of the unstirred water layer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of a protein-bound polar compound, acetaminophen sulfate, by perfused rat liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-brain barrier drug targeting: the future of brain drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal permeability and excretion into bile control the arrival of amlodipine into the systemic circulation after oral administration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Man versus beast: pharmacokinetic scaling in mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfer of enalaprilat across rat liver cell membranes is barrier limited

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A proposed blood circulation model for Reference Man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of the cyclooxygenase inhibiting nitric oxide donator (CINOD) AZD3582.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passage of organic bases into human red cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of in vitro BBMEC permeability and in vivo CNS uptake by microdialysis sampling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between clarithromycin and digoxin in patients with end-stage renal disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison between permeability coefficients in rat and human jejunum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of nonelectrolyte permeability in human red blood cell membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of allometry in predicting anatomical and physiological parameters of mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of organ availability by sequential and simultaneous analyses: intestinal conjugative metabolism impacts on intestinal availability in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17710514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-007-9397-Y

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

release_q6zlrve5rngpnpntmde45q6v5a

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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