(Q39895269)

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DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif

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scholarly article

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Europe PubMed Central

PubMed publication ID

15 September 2017

DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif (English)

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Europe PubMed Central

PubMed publication ID

15 September 2017

phosphorylation

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based on heuristic

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15 September 2017

6

object named as

Brian A Hemmings

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Europe PubMed Central

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15 September 2017

author name string

Jianhua Feng

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Europe PubMed Central

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15 September 2017

Yuwen Li

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Europe PubMed Central

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15 September 2017

Ola Hammarsten

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Europe PubMed Central

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15 September 2017

Derek P Brazil

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Europe PubMed Central

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15 September 2017

language of work or name

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publication date

14 January 2009

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Europe PubMed Central

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15 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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15 September 2017

284

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15 September 2017

10

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15 September 2017

6169-6174

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15 September 2017

Physiological roles of PKB/Akt isoforms in development and disease

1 reference

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The protein kinase B/Akt signalling pathway in human malignancy

1 reference

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Protein kinase B/Akt at a glance

1 reference

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High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

1 reference

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21 January 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

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21 January 2018

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

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21 January 2018

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

1 reference

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21 January 2018

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

1 reference

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21 January 2018

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

1 reference

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21 January 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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21 January 2018

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

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21 January 2018

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

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21 January 2018

The DNA-dependent protein kinase: the director at the end.

1 reference

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21 January 2018

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen

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21 January 2018

Role of DNA-PK in the cellular response to DNA double-strand breaks

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21 January 2018

The Greek Goddess, Artemis, reveals the secrets of her cleavage

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21 January 2018

DNA-dependent protein kinase catalytic subunit. Structural requirements for kinase activation by DNA ends

1 reference

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21 January 2018

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1 reference

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21 January 2018

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding

1 reference

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21 January 2018

The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity

1 reference

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21 January 2018

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity

1 reference

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21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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21 January 2018

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis

1 reference

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21 January 2018

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

1 reference

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21 January 2018

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

Artemis links ATM to double strand break rejoining

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C800210200

21 January 2018

Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells.

1 reference

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21 January 2018

AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans

1 reference

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21 January 2018

Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP6 inhibits Ku mobility

1 reference

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21 January 2018

Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs

1 reference

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21 January 2018

Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

1 reference

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21 January 2018

Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase

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21 January 2018

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

1 reference

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

1 reference

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AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition

1 reference

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21 January 2018

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

1 reference

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21 January 2018

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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21 January 2018

Identifiers

10.1074/JBC.C800210200

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

ResearchGate publication ID

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