(Q40048813)

English

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding

scientific article published on 16 November 2007

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scholarly article

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Europe PubMed Central

PubMed publication ID

16 September 2017

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding (English)

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Europe PubMed Central

PubMed publication ID

16 September 2017

phosphorylation

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based on heuristic

inferred from title

16

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Brian A Hemmings

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16 September 2017

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Keum-Jin Yang

1

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16 September 2017

Sanghee Shin

2

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16 September 2017

Longzhen Piao

3

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16 September 2017

Eulsoon Shin

4

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16 September 2017

Yuwen Li

5

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16 September 2017

Kyeong Ah Park

6

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16 September 2017

Hee Sun Byun

7

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16 September 2017

Minho Won

8

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16 September 2017

Janghee Hong

9

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16 September 2017

Gi Ryang Kweon

10

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16 September 2017

Gang Min Hur

11

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16 September 2017

Jeong Ho Seok

12

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16 September 2017

Taehoon Chun

13

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16 September 2017

Derek P Brazil

14

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16 September 2017

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publication date

16 November 2007

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16 September 2017

Journal of Biological Chemistry

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16 September 2017

283

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16 September 2017

3

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16 September 2017

1480-1491

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16 September 2017

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

"New"-clear functions of PDK1: beyond a master kinase in the cytosol?

1 reference

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21 January 2018

Protein kinase B/Akt at a glance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

PDK1, the master regulator of AGC kinase signal transduction

1 reference

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21 January 2018

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

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21 January 2018

Essential role of PDK1 in regulating cell size and development in mice

1 reference

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21 January 2018

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

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21 January 2018

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

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21 January 2018

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

1 reference

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21 January 2018

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

1 reference

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21 January 2018

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity

1 reference

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21 January 2018

Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1).

1 reference

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21 January 2018

Roles of 3-phosphoinositide-dependent kinase 1 in the regulation of endothelial nitric-oxide synthase phosphorylation and function by heat shock protein 90.

1 reference

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21 January 2018

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

1 reference

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21 January 2018

Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells

1 reference

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21 January 2018

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1 reference

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21 January 2018

Sensitivity and detection efficiency of the peroxidase antiperoxidase (PAP), avidin-biotin peroxidase complex (ABC), and peroxidase-labeled avidin-biotin (LAB) methods.

1 reference

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21 January 2018

Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

1 reference

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21 January 2018

Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

1 reference

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21 January 2018

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

1 reference

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21 January 2018

3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases

1 reference

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21 January 2018

Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

H2O2-induced phosphorylation of ERK1/2 and PKB requires tyrosine kinase activity of insulin receptor and c-Src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Activation of insulin-like growth factor type-1 receptor is required for H2O2-induced PKB phosphorylation in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Regulation of Akt/PKB activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Modulation of Akt kinase activity by binding to Hsp90

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3

1 reference

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21 January 2018

Survival-signaling pathway as a promising target for cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Heat shock protein-90 dampens and directs signaling stimulated by insulin-like growth factor-1 and insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Physiological roles of PKB/Akt isoforms in development and disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Unusual expression and localization of heat-shock proteins in human tumor cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

High constitutive expression of heat shock protein 90α in human acute leukemia cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706361200

21 January 2018

Identifiers

10.1074/JBC.M706361200

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

ResearchGate publication ID

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