(Q39966104)

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Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.

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1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11. (English)

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

transmembrane protein

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author name string

Tip W Loo

1

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

M Claire Bartlett

2

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

David M Clarke

3

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

language of work or name

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publication date

2 July 2008

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

283

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

36

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

24860-24870

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Flexibility in the ABC transporter MsbA: Alternating access with a twist

1 reference

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22 September 2017

Is arginine charged in a membrane?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Suppressor mutations in the transmembrane segments of P-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites.

1 reference

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22 September 2017

Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein

1 reference

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22 September 2017

On the thermodynamic stability of a charged arginine side chain in a transmembrane helix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Structure of a bacterial multidrug ABC transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Insertion of an arginine residue into the transmembrane segments corrects protein misfolding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Predicting the effects of amino acid substitutions on protein function

1 reference

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22 September 2017

Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket

1 reference

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22 September 2017

Specific rescue of cystic fibrosis transmembrane conductance regulator processing mutants using pharmacological chaperones

1 reference

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22 September 2017

Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

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Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules

1 reference

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Probing ion-channel pores one proton at a time

1 reference

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22 September 2017

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

1 reference

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22 September 2017

ATP hydrolysis promotes interactions between the extracellular ends of transmembrane segments 1 and 11 of human multidrug resistance P-glycoprotein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Non-native interhelical hydrogen bonds in the cystic fibrosis transmembrane conductance regulator domain modulated by polar mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Disease-related misassembly of membrane proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Permanent Activation of the Human P-glycoprotein by Covalent Modification of a Residue in the Drug-binding Site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Cation-pi interactions in structural biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

DNA sequencing with chain-terminating inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

22 September 2017

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

25 September 2017

Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

25 September 2017

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

25 September 2017

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

25 September 2017

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

25 September 2017

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

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25 September 2017

P-glycoprotein. Associations between domains and between domains and molecular chaperones

1 reference

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25 September 2017

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

1 reference

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15 June 2018

Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis.

1 reference

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15 June 2018

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

15 June 2018

Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein

1 reference

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15 June 2018

Snorkeling preferences foster an amino acid composition bias in transmembrane helices

1 reference

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20 August 2018

Val133 and Cys137 in transmembrane segment 2 are close to Arg935 and Gly939 in transmembrane segment 11 of human P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

20 August 2018

P-glycoprotein does not reduce substrate concentration from the extracellular leaflet of the plasma membrane in living cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

20 August 2018

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259837

20 August 2018

Cystic fibrosis-type mutational analysis in the ATP-binding cassette transporter signature of human P-glycoprotein MDR1.

1 reference

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20 August 2018

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803351200

21 January 2018

Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803351200

21 January 2018

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803351200

21 January 2018

Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803351200

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Interhelical hydrogen bonds in the CFTR membrane domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M803351200

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

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