(Q40608295)

English

Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane

scientific article published on 10 December 2003

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scholarly article

1 reference

Europe PubMed Central

22 September 2017

Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane (English)

1 reference

Europe PubMed Central

22 September 2017

transmembrane protein

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author name string

Tip W Loo

1

1 reference

Europe PubMed Central

22 September 2017

M Claire Bartlett

2

1 reference

Europe PubMed Central

22 September 2017

David M Clarke

3

1 reference

Europe PubMed Central

22 September 2017

language of work or name

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publication date

10 December 2003

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Europe PubMed Central

22 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

22 September 2017

279

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Europe PubMed Central

22 September 2017

7692-7697

1 reference

Europe PubMed Central

22 September 2017

9

1 reference

Europe PubMed Central

22 September 2017

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

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21 January 2018

Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance

1 reference

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21 January 2018

Multidrug resistance in cancer: role of ATP-dependent transporters

1 reference

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21 January 2018

The human ATP-binding cassette (ABC) transporter superfamily

1 reference

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21 January 2018

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

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21 January 2018

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

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21 January 2018

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

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21 January 2018

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

1 reference

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21 January 2018

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

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21 January 2018

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

The minimum functional unit of human P-glycoprotein appears to be a monomer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

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21 January 2018

The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

1 reference

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21 January 2018

P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state

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21 January 2018

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

1 reference

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21 January 2018

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

1 reference

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21 January 2018

Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites

1 reference

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21 January 2018

Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

1 reference

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21 January 2018

Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein

1 reference

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21 January 2018

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

1 reference

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21 January 2018

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

P-glycoprotein. Associations between domains and between domains and molecular chaperones

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Permanent Activation of the Human P-glycoprotein by Covalent Modification of a Residue in the Drug-binding Site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

1 reference

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21 January 2018

Mutational analysis of human P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation

1 reference

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21 January 2018

Function of Escherichia coli MsbA, an essential ABC family transporter, in lipid A and phospholipid biosynthesis

1 reference

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21 January 2018

An Escherichia coli mutant defective in lipid export

1 reference

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21 January 2018

RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

1 reference

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21 January 2018

Ligand-induced changes in periplasmic loops in the lactose permease of Escherichia coli

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21 January 2018

Molecular mechanism of transmembrane signaling by the aspartate receptor: a model

1 reference

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21 January 2018

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

1 reference

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21 January 2018

Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

1 reference

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21 January 2018

Molecular dissection of the human multidrug resistance P-glycoprotein

1 reference

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21 January 2018

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

1 reference

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21 January 2018

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311825200

21 January 2018

Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

1 reference

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21 January 2018

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

1 reference

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21 January 2018

Mutational Analysis of the Predicted First Transmembrane Segment of Each Homologous Half of Human P-glycoprotein Suggests That They Are Symmetrically Arranged in the Membrane

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M311825200

1 reference

Europe PubMed Central

22 September 2017

1 reference

Europe PubMed Central

22 September 2017

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