(Q40033943)

16 September 2017

title

RAG-heptamer interaction in the synaptic complex is a crucial biochemical checkpoint for the 12/23 recombination rule (English)

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16 September 2017

Tadashi Nishihara

1

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16 September 2017

Fumikiyo Nagawa

series ordinal

2

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16 September 2017

Takeshi Imai

series ordinal

3

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16 September 2017

Hitoshi Sakano

series ordinal

4

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16 September 2017

language of work or name

English

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publication date

18 December 2007

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Journal of Biological Chemistry

16 September 2017

number of pages

9

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based on heuristic

inferred from page(s)

published in

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16 September 2017

volume

283

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16 September 2017

issue

8

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16 September 2017

page(s)

4877-4885

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Somatic generation of antibody diversity

16 September 2017

cites work

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21 January 2018

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RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

21 January 2018

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Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences

21 January 2018

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V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

21 January 2018

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21 January 2018

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Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.

21 January 2018

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A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

21 January 2018

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Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.

21 January 2018

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RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination

21 January 2018

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Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking

21 January 2018

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RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro

21 January 2018

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Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining

21 January 2018

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Genomic instability due to V(D)J recombination-associated transposition.

21 January 2018

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Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

21 January 2018

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DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

21 January 2018

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V(D)J recombination and RAG-mediated transposition in yeast.

21 January 2018

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In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

21 January 2018

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Mobilization of RAG-generated signal ends by transposition and insertion in vivo

21 January 2018

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RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons

21 January 2018

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An ancient evolutionary origin of the Rag1/2 gene locus

21 January 2018

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The genome of the sea urchin Strongylocentrotus purpuratus

21 January 2018

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The phylogenetic origins of the antigen-binding receptors and somatic diversification mechanisms

21 January 2018

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Mechanisms of antigen receptor evolution

21 January 2018

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

21 January 2018

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21 January 2018

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The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

21 January 2018

1 reference

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Initiation of V(D)J recombination in vitro obeying the 12/23 rule

21 January 2018

1 reference

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Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination

21 January 2018

1 reference

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Ordered assembly of the V(D)J synaptic complex ensures accurate recombination

21 January 2018

1 reference

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The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step

21 January 2018

1 reference

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Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Assembly of the RAG1/RAG2 synaptic complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Functional analysis of coordinated cleavage in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Single-strand recombination signal sequence nicks in vivo: evidence for a capture model of synapsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA.

21 January 2018

1 reference

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In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Identification and characterization of a gain-of-function RAG-1 mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Initiation of V(D)J recombination in a cell-free system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

The taming of a transposon: V(D)J recombination and the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Requirements for DNA hairpin formation by RAG1/2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Putting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Functional organization of single and paired V(D)J cleavage complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

Amino acid residues in Rag1 crucial for DNA hairpin formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709890200

21 January 2018

Identifiers

DOI

10.1074/JBC.M709890200

1 reference

16 September 2017

1 reference