(Q40113987)

17 September 2017

title

Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences (English)

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17 September 2017

3

Ruth Nussinov

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17 September 2017

2

Hyunbum Jang

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17 September 2017

1

Mayukh Chakrabarti

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17 September 2017

language of work or name

English

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publication date

13 January 2016

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Journal of Physical Chemistry B

17 September 2017

published in

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17 September 2017

volume

120

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17 September 2017

issue

4

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17 September 2017

page(s)

667-679

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Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells

17 September 2017

cites work

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12 December 2020

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.

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12 December 2020

Polylysine domain of K-ras 4B protein is crucial for malignant transformation

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12 December 2020

VMD: visual molecular dynamics

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Developmentally-regulated expression of murine K-ras isoforms.

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Ligand-induced conformational changes in ras p21: a normal mode and energy minimization analysis.

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12 December 2020

Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo

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12 December 2020

The structural basis of the activation of Ras by Sos

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12 December 2020

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

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12 December 2020

Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor

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12 December 2020

Alternative splicing of the K-ras gene in mouse tissues and cell lines

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12 December 2020

Blocking oncogenic Ras signaling for cancer therapy

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12 December 2020

The guanine nucleotide-binding switch in three dimensions

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12 December 2020

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

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12 December 2020

RAS oncogenes: the first 30 years.

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12 December 2020

NMR characterization of full-length farnesylated and non-farnesylated H-Ras and its implications for Raf activation

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12 December 2020

Detecting changes in the relative expression of KRAS2 splice variants using polymerase colonies

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12 December 2020

Structure of the G60A mutant of Ras: implications for the dominant negative effect

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12 December 2020

Scalable molecular dynamics with NAMD

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12 December 2020

Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype

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12 December 2020

K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer

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12 December 2020

Bio3d: an R package for the comparative analysis of protein structures.

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12 December 2020

Hyperactive Ras in developmental disorders and cancer

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12 December 2020

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

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12 December 2020

GEFs and GAPs: critical elements in the control of small G proteins

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12 December 2020

Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis

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12 December 2020

Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain.

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12 December 2020

Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins

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12 December 2020

Ras oncogenes: split personalities

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12 December 2020

Kras regulatory elements and exon 4A determine mutation specificity in lung cancer

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Ras acylation, compartmentalization and signaling nanoclusters (Review).

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12 December 2020

Isoform-specific ras functions in development and cancer

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12 December 2020

Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics

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12 December 2020

Dynamical networks in tRNA:protein complexes

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12 December 2020

CHARMM: the biomolecular simulation program

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12 December 2020

Implications for KRAS status and EGFR-targeted therapies in metastatic CRC.

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12 December 2020

Characterization of a Ras mutant with identical GDP- and GTP-bound structures

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12 December 2020

Ras membrane orientation and nanodomain localization generate isoform diversity

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12 December 2020

K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.

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12 December 2020

Allosteric modulation of Ras positions Q61 for a direct role in catalysis

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12 December 2020

The distinct conformational dynamics of K-Ras and H-Ras A59G

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12 December 2020

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

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12 December 2020

Relation between the conformational heterogeneity and reaction cycle of Ras: molecular simulation of Ras.

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12 December 2020

SHIFTX2: significantly improved protein chemical shift prediction

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12 December 2020

Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events.

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12 December 2020

Functional specificity of ras isoforms: so similar but so different

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12 December 2020

Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives

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12 December 2020

Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells

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12 December 2020

Therapeutic strategies for targeting ras proteins

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12 December 2020

Ras trafficking, localization and compartmentalized signalling

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12 December 2020

Regulating the regulator: post-translational modification of RAS

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12 December 2020

The role of conserved waters in conformational transitions of Q61H K-ras

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12 December 2020

NetworkView: 3D display and analysis of protein·RNA interaction networks

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12 December 2020

Compartmentalized Ras signaling differentially contributes to phenotypic outputs

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12 December 2020

MEK targeting in N-RAS mutated metastatic melanoma

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12 December 2020

Chemical biology tools for regulating RAS signaling complexity in space and time

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12 December 2020

Drugging the undruggable RAS: Mission possible?

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12 December 2020

Integrating protein structural dynamics and evolutionary analysis with Bio3D.

1 reference

12 December 2020

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

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12 December 2020

Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region

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12 December 2020

Differential dynamics of RAS isoforms in GDP- and GTP-bound states.

1 reference

12 December 2020

GTP-Dependent K-Ras Dimerization

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12 December 2020

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

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12 December 2020

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

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12 December 2020

Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation

1 reference

12 December 2020

Inhibitors of Ras-SOS Interactions

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12 December 2020

A New View of Ras Isoforms in Cancers

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12 December 2020

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

1 reference

12 December 2020

The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding

1 reference

12 December 2020

The higher level of complexity of K-Ras4B activation at the membrane

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12 December 2020

Ras Conformational Ensembles, Allostery, and Signaling

1 reference

12 December 2020

K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?

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12 December 2020

Identifiers

DOI

10.1021/ACS.JPCB.5B11110

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17 September 2017

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