(Q36323471)

English

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

object named as

Hyunbum Jang

3

0 references

6

object named as

Ruth Nussinov

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Vadim Gaponenko

5

object named as

Vadim Gaponenko

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

2

object named as

Avik Banerjee

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

author name string

Shaoyong Lu

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Jian Zhang

4

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Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

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publication date

9 October 2015

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

number of pages

14

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inferred from page(s)

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

13 August 2017

290

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

48

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

28887-28900

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

1 reference

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Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.

1 reference

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Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

1 reference

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30 September 2017

GTP-Dependent K-Ras Dimerization

1 reference

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Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme

1 reference

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Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region

1 reference

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Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

1 reference

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The efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer-specific nanoclustering.

1 reference

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1 reference

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The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.

1 reference

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

1 reference

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1 reference

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Allostery in disease and in drug discovery

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1 reference

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1 reference

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Organization, dynamics, and segregation of Ras nanoclusters in membrane domains

1 reference

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

1 reference

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Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers

1 reference

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Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events.

1 reference

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The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin

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Membrane binding of lipidated Ras peptides and proteins--the structural point of view

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Free energy profile of H-ras membrane anchor upon membrane insertion

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1 reference

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GEFs and GAPs: critical elements in the control of small G proteins

1 reference

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Lipid posttranslational modifications. Farnesyl transferase inhibitors

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M115.664755

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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