(Q35859222)

10 August 2017

title

Inhibitors of Ras-SOS Interactions (English)

1 reference

10 August 2017

4

Ruth Nussinov

1 reference

10 August 2017

2

Hyunbum Jang

1 reference

10 August 2017

Shaoyong Lu

1

1 reference

10 August 2017

Jian Zhang

series ordinal

3

1 reference

10 August 2017

publication date

2 December 2015

1 reference

10 August 2017

1 reference

10 August 2017

volume

11

1 reference

10 August 2017

issue

8

1 reference

10 August 2017

page(s)

814-821

1 reference

Principles of protein-protein interactions: what are the preferred ways for proteins to interact?

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

The underappreciated role of allostery in the cellular network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Modulators of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Small molecule modulators of protein-protein interactions: selected case studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Protein-protein interactions: organization, cooperativity and mapping in a bottom-up Systems Biology approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Direct monitoring of the inhibition of protein-protein interactions in cells by translocation of PKCδ fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

A human protein-protein interaction network: a resource for annotating the proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Protein-protein interactions in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Comprehensive peptidomimetic libraries targeting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Harnessing allostery: a novel approach to drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Recent computational advances in the identification of allosteric sites in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

ASBench: benchmarking sets for allosteric discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

'Pathway drug cocktail': targeting Ras signaling based on structural pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Structure-function relationships of the G domain, a canonical switch motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

The guanine nucleotide-binding switch in three dimensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

GTP-Dependent K-Ras Dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Regulation of small GTPases by GEFs, GAPs, and GDIs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

G proteins, effectors and GAPs: structure and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

The interaction of Ras with GTPase-activating proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Blocking oncogenic Ras signaling for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Hyperactive Ras in developmental disorders and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

A comprehensive survey of Ras mutations in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Dragging ras back in the ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Drugging the undruggable RAS: Mission possible?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Current status of the development of Ras inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

21 January 2018

The renaissance of Ras.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Small-molecule modulation of Ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Direct Inhibitors of Ras-Effector Protein Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Inhibition of Ras signaling by blocking Ras-effector interactions with cyclic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

RAS oncogenes: the first 30 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

How does the switch II region of G-domains work?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Digital signaling and hysteresis characterize ras activation in lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Detection and structural characterization of ras oncoprotein-inhibitors complexes by electrospray mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Design, synthesis and biological evaluation of sugar-derived Ras inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

An orthosteric inhibitor of the Ras-Sos interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Direct Modulation of Small GTPase Activity and Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Intracellular antibody capture: A molecular biology approach to inhibitors of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Cancer: The Ras renaissance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

Erratum: Drugging the p53 pathway: understanding the route to clinical efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

7 January 2021

Small GTP-binding proteins

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

7 January 2021

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

7 January 2021

Regulation of ras signaling dynamics by Sos-mediated positive feedback

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500481

7 January 2021

Identifiers

DOI

10.1002/CMDC.201500481

1 reference

release_lq5sovzbjnax7aomk2dau323qy

10 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lq5sovzbjnax7aomk2dau323qy

24 November 2022

mapped directly with Wikidata item

1 reference