(Q40183194)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17701350%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Insulysin cleaves the APP cytoplasmic fragment at multiple sites (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17701350%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17701350%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

author name string

Chitra Venugopal

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17701350%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Miguel A Pappolla

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17701350%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

language of work or name

1 reference

15 August 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17701350%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

published in

Neurochemical Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17701350%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

volume

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17701350%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17701350%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

page(s)

2225-2234

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17701350%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s11064-007-9449-z

3 January 2020

exact match

0 references

cites work

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11064-007-9449-Z

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11064-007-9449-Z

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

21 January 2018

1 reference

12 December 2020

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

12 December 2020

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

12 December 2020

feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping.

1 reference

12 December 2020

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

1 reference

12 December 2020

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

1 reference

12 December 2020

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

1 reference

12 December 2020

The Alzheimer's Amyloid Precursor Is Cleaved Intracellularly in the Trans‐Golgi Network or in a Post‐Golgi Compartment a

1 reference

12 December 2020

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

1 reference

12 December 2020

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

1 reference

12 December 2020

Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors.

1 reference

12 December 2020

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

1 reference

12 December 2020

The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo

1 reference

12 December 2020

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

12 December 2020

Segregation of a missense mutation in the amyloid beta-protein precursor gene with familial Alzheimer's disease.

1 reference

12 December 2020

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

1 reference

12 December 2020

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

1 reference

12 December 2020

PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein

1 reference

12 December 2020

The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system

1 reference

12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

12 December 2020

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

1 reference

12 December 2020

Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease

1 reference

12 December 2020

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

1 reference

12 December 2020

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

12 December 2020

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

1 reference

12 December 2020

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

1 reference

12 December 2020

Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme.

1 reference

12 December 2020

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

12 December 2020

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

1 reference

12 December 2020

Mutations in APP have independent effects on Abeta and CTFgamma generation

1 reference

12 December 2020

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

1 reference

12 December 2020

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

1 reference

12 December 2020

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

1 reference

12 December 2020

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

1 reference

12 December 2020

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

1 reference

12 December 2020

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

12 December 2020

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

1 reference

12 December 2020

Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread

1 reference

12 December 2020

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

1 reference

12 December 2020

Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease

1 reference

12 December 2020

Molecular genetics of Alzheimer’s disease

1 reference

12 December 2020

hFE65L influences amyloid precursor protein maturation and secretion

1 reference

12 December 2020

Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?

1 reference

12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

12 December 2020

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

1 reference

12 December 2020

DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing

1 reference

12 December 2020

APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain

1 reference

12 December 2020

RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation

1 reference

12 December 2020

Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain

1 reference

12 December 2020

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

1 reference

12 December 2020

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

1 reference

12 December 2020

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

12 December 2020

Presenilin function and gamma-secretase activity

1 reference

12 December 2020