(Q40511094)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15448134%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization (English)

1 reference

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3 January 2020

5

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3 January 2020

author name string

Marc Vooijs

1

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3 January 2020

Eric H Schroeter

2

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3 January 2020

Yonghua Pan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15448134%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Mary Blandford

4

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3 January 2020

language of work or name

English

0 references

publication date

23 September 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15448134%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

3 January 2020

published in

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3 January 2020

volume

279

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3 January 2020

page(s)

50864-50873

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3 January 2020

issue

49

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15448134%20AND%20SRC:MED&resulttype=core&format=json

Notch signaling and inherited disease syndromes

3 January 2020

cites work

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The role of Notch in tumorigenesis: oncogene or tumour suppressor?

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Calcium depletion dissociates and activates heterodimeric notch receptors

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The Notch pathway: democracy and aristocracy in the selection of cell fate

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Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

21 January 2018

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Notch signaling: endocytosis makes delta signal better

21 January 2018

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Notch signaling: from the outside in

21 January 2018

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

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Regulation of notch signaling activity

21 January 2018

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Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data

21 January 2018

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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

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Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

21 January 2018

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Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

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Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

21 January 2018

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Intramembrane proteolysis controls diverse signalling pathways throughout evolution

21 January 2018

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Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis

21 January 2018

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Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

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Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

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A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

21 January 2018

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Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila.

21 January 2018

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Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans.

21 January 2018

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Structure and stability of the ankyrin domain of the Drosophila Notch receptor

21 January 2018

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Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans

21 January 2018

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Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

21 January 2018

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The LIN-12/Notch signaling pathway and its regulation

21 January 2018

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TOXCAT: a measure of transmembrane helix association in a biological membrane

21 January 2018

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Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Signalling downstream of activated mammalian Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

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Patched acts catalytically to suppress the activity of Smoothened

21 January 2018

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

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Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

21 January 2018

1 reference

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The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1

21 January 2018

1 reference

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Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification

21 January 2018

1 reference

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Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants

21 January 2018

1 reference

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The single transmembrane domains of ErbB receptors self-associate in cell membranes

21 January 2018

1 reference

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain

21 January 2018

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

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F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation

21 January 2018

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Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney

21 January 2018

1 reference

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Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail.

21 January 2018

1 reference

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Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1.

21 January 2018

1 reference

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Proteolysis within the membrane: rhomboids revealed

21 January 2018

1 reference

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kuzbanian-mediated cleavage of Drosophila Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

ER transport signals and trafficking of potassium channels and receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Evidence for a physical interaction between presenilin and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409430200

21 January 2018

Identifiers

DOI

10.1074/JBC.M409430200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15448134%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference