(Q35079442)

6 August 2017

1 reference

title

Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis (English)

1 reference

6 August 2017

1 reference

Todd E Golde

1

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6 August 2017

Christopher B Eckman

series ordinal

2

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6 August 2017

publication date

4 March 2003

1 reference

Science's STKE : signal transduction knowledge environment

6 August 2017

published in

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6 August 2017

volume

2003

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6 August 2017

issue

172

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6 August 2017

page(s)

RE4

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

SCAP, an ER sensor that regulates cell cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A novel clan of zinc metallopeptidases with possible intramembrane cleavage properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Identification of the cAD1 sex pheromone precursor in Enterococcus faecalis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A sporulation membrane protein tethers the pro-sigmaK processing enzyme to its inhibitor and dictates its subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Morphological coupling in development: lessons from prokaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Evidence that SpoIVFB is a novel type of membrane metalloprotease governing intercompartmental communication during Bacillus subtilis sporulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Cellular mechanisms of beta-amyloid production and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A familial Alzheimer's disease locus on chromosome 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Identification of a novel family of presenilin homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Methyl rotational barriers in amides and thioamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilins as therapeutic targets for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Notch signaling during vascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Notch signaling in vertebrate development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Notch signaling in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Calcium depletion dissociates and activates heterodimeric notch receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

kuzbanian-mediated cleavage of Drosophila Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Principles of cargo attachment to cytoplasmic motor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

The PA domain: a protease-associated domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Membrane protein secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Tumor necrosis factor-alpha converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Caspases: more than just killers?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Proteolytic cleavage of epidermal growth factor receptor by caspases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Metformin reverses fatty liver disease in obese, leptin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

Gamma -secretase inhibitors repress thymocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.172.RE4

10.1126/STKE.2003.172.RE4

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

1 reference