(Q40590032)

English

Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251.

scientific article published on 12 February 2004

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scholarly article

1 reference

Europe PubMed Central

21 September 2017

Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251. (English)

1 reference

Europe PubMed Central

21 September 2017

author name string

Madeline Leahy

1

1 reference

Europe PubMed Central

21 September 2017

Anthony Lyons

2

1 reference

Europe PubMed Central

21 September 2017

Darren Krause

3

1 reference

Europe PubMed Central

21 September 2017

Rosemary O'Connor

4

1 reference

Europe PubMed Central

21 September 2017

language of work or name

0 references

publication date

12 February 2004

1 reference

Europe PubMed Central

21 September 2017

number of pages

8

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

21 September 2017

279

1 reference

Europe PubMed Central

21 September 2017

18306-18313

1 reference

Europe PubMed Central

21 September 2017

18

1 reference

Europe PubMed Central

21 September 2017

Control of cell survival by IGF signaling pathways.

1 reference

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21 January 2018

Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis

1 reference

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21 January 2018

Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling

1 reference

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21 January 2018

Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

The IGF-I receptor in cancer research

1 reference

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21 January 2018

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation

1 reference

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21 January 2018

The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

1 reference

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21 January 2018

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma

1 reference

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21 January 2018

Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells

1 reference

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21 January 2018

Tyrosine residues in the C-terminal domain of the insulin-like growth factor-I receptor mediate mitogenic and tumorigenic signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Replacement of tyrosine 1251 in the carboxyl terminus of the insulin-like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Insulin-like growth factor-I-mediated neurite outgrowth in vitro requires mitogen-activated protein kinase activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Tyrosine residues 239 and 240 of Shc are phosphatidylinositol 4,5-bisphosphate-dependent phosphorylation sites by c-Src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Relative involvement of Shc tyrosine 239/240 and tyrosine 317 on insulin induced mitogenic signaling in rat1 fibroblasts expressing insulin receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

At the onset of transformation polyomavirus middle-T recruits shc and src to a perinuclear compartment coincident with condensation of endosomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Negative signaling in B cells: SHIP Grbs Shc.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Ras superfamily monomeric G proteins in carcinoma cell motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Raf-independent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Ras effectors and their role in mitogenesis and oncogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Crk activation of JNK via C3G and R-Ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Activation of the JNK signaling pathway: breaking the brake on apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

JunD mediates survival signaling by the JNK signal transduction pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

The tyrosine residue at 1250 of the insulin-like growth factor I receptor is required for ligand-mediated internalization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Overexpression of the insulin-like growth factor I receptor in human colon carcinomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309234200

21 January 2018

Identifiers

10.1074/JBC.M309234200

1 reference

Europe PubMed Central

21 September 2017

1 reference

Europe PubMed Central

21 September 2017

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