(Q41463478)

English

Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway

scientific article published on 3 October 2012

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scholarly article

1 reference

Europe PubMed Central

1 October 2017

Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway (English)

1 reference

Europe PubMed Central

1 October 2017

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based on heuristic

inferred from title

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based on heuristic

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based on heuristic

inferred from title

Makoto Taniguchi

1

object named as

Makoto Taniguchi

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Kazuyuki Kitatani

2

object named as

Kazuyuki Kitatani

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author name string

Tadakazu Kondo

3

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Europe PubMed Central

1 October 2017

Mayumi Hashimoto-Nishimura

4

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Europe PubMed Central

1 October 2017

Satoshi Asano

5

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Europe PubMed Central

1 October 2017

Akira Hayashi

6

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Europe PubMed Central

1 October 2017

Susumu Mitsutake

7

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Europe PubMed Central

1 October 2017

Yasuyuki Igarashi

8

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Europe PubMed Central

1 October 2017

Hisanori Umehara

9

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Europe PubMed Central

1 October 2017

Hiroyuki Takeya

10

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Europe PubMed Central

1 October 2017

Junzo Kigawa

11

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Europe PubMed Central

1 October 2017

Toshiro Okazaki

12

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Europe PubMed Central

1 October 2017

language of work or name

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publication date

3 October 2012

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Europe PubMed Central

1 October 2017

Journal of Biological Chemistry

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Europe PubMed Central

1 October 2017

287

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Europe PubMed Central

1 October 2017

47

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Europe PubMed Central

1 October 2017

39898-39910

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Europe PubMed Central

1 October 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3501064/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia

1 reference

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11 June 2018

Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

1 reference

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Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation

1 reference

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11 June 2018

Mammalian autophagy: core molecular machinery and signaling regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

1 reference

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11 June 2018

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response.

1 reference

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Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation

1 reference

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The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

1 reference

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S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.

1 reference

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Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

1 reference

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PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects

1 reference

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11 June 2018

Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy

1 reference

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11 June 2018

Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM.

1 reference

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Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

1 reference

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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

1 reference

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11 June 2018

Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Autophagy fights disease through cellular self-digestion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Principles of bioactive lipid signalling: lessons from sphingolipids

1 reference

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11 June 2018

The sphingolipid salvage pathway in ceramide metabolism and signaling

1 reference

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11 June 2018

Role of autophagy in cancer

1 reference

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Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

1 reference

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11 June 2018

Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells

1 reference

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11 June 2018

Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

TOR signaling in growth and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation

1 reference

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The role of autophagy in cancer development and response to therapy.

1 reference

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11 June 2018

The ins and outs of sphingolipid synthesis

1 reference

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11 June 2018

The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Biologically active sphingolipids in cancer pathogenesis and treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

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11 June 2018

Sphingosine-1-phosphate: an enigmatic signalling lipid

1 reference

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Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

1 reference

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Sphingosine 1-phosphate as a therapeutic agent

1 reference

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1 reference

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Ceramide accumulation is independent of camptothecin-induced apoptosis in prostate cancer LNCaP cells

1 reference

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Lysophospholipids--receptor revelations

1 reference

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Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration

1 reference

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FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1.

1 reference

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Characterization of a novel sphingosine 1-phosphate receptor, Edg-8

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

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1 reference

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Downregulation of mRNA expression of Edg-3, a putative sphingosine 1-phosphate receptor coupled to Ca2+ signaling, during differentiation of HL-60 leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

11 June 2018

Regulation of ceramide production and apoptosis

1 reference

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11 June 2018

Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1

1 reference

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Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids

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Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology

1 reference

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11 June 2018

Functions of ceramide in coordinating cellular responses to stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

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Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

1 reference

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11 June 2018

Ceramide activates heterotrimeric protein phosphatase 2A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

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1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells

1 reference

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Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies.

1 reference

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Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

1 reference

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19 August 2018

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression

1 reference

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19 August 2018

Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501064

19 August 2018

Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3.

1 reference

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Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles.

1 reference

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Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.416552

1 reference

Europe PubMed Central

1 October 2017

1 reference

Europe PubMed Central

1 October 2017

1 reference

Europe PubMed Central

1 October 2017

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