(Q42062886)

15 October 2017

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression (English)

1 reference

15 October 2017

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1 reference

Deron Herr

2

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author name string

Connie Chao

series ordinal

1

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15 October 2017

Jerold Chun

series ordinal

3

1 reference

15 October 2017

Yang Xu

series ordinal

4

1 reference

15 October 2017

language of work or name

English

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publication date

1 June 2006

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15 October 2017

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15 October 2017

25

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15 October 2017

11

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15 October 2017

2615-2622

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DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis

15 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

The ubiquitin ligase COP1 is a critical negative regulator of p53

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Regulation of p53 responses by post-translational modifications

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Analysing p53 tumour suppressor functions in mice

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Mutation of mouse p53 Ser23 and the response to DNA damage

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Rescue of defective T cell development and function in Atm-/- mice by a functional TCR alpha beta transgene

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Regulation of p53 stability by Mdm2

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Mdm2 promotes the rapid degradation of p53

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

5 June 2018

p53: puzzle and paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Abnormal centrosome amplification in the absence of p53.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Tumor spectrum analysis in p53-mutant mice

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

p53 mutations in human cancers

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Radiation-induced apoptosis in developing mouse retina exhibits dose-dependent requirement for ATM phosphorylation of p53.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1478190

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

17 August 2018

1 reference

12 December 2020

Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice

1 reference

12 December 2020

Regulation of DNA binding and transactivation in p53 by nuclear localization and phosphorylation

1 reference

12 December 2020

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.EMBOJ.7601167

1 reference

15 October 2017

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15 October 2017

PubMed publication ID

16757976

1 reference