(Q42152060)

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Comprehensive experimental and computational analysis of binding energy hot spots at the NF-κB essential modulator/IKKβ protein-protein interface

scientific article published on 10 April 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

17 October 2017

Comprehensive experimental and computational analysis of binding energy hot spots at the NF-κB essential modulator/IKKβ protein-protein interface (English)

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Europe PubMed Central

PMC publication ID

17 October 2017

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computational biology

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Rosina M Georgiadis

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Rosina M Georgiadis

8

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Dima Kozakov

10

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Mary S Golden

1

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Europe PubMed Central

PMC publication ID

17 October 2017

Shaun M Cote

2

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Europe PubMed Central

PMC publication ID

17 October 2017

Marianna Sayeg

3

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Europe PubMed Central

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17 October 2017

Brandon S Zerbe

4

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Europe PubMed Central

PMC publication ID

17 October 2017

Elizabeth A Villar

5

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Europe PubMed Central

PMC publication ID

17 October 2017

Dmitri Beglov

6

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Europe PubMed Central

PMC publication ID

17 October 2017

Stephen L Sazinsky

7

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Europe PubMed Central

PMC publication ID

17 October 2017

Sandor Vajda

9

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Europe PubMed Central

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17 October 2017

Adrian Whitty

11

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17 October 2017

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10 April 2013

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17 October 2017

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15

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Journal of the American Chemical Society

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17 October 2017

135

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17 October 2017

16

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Europe PubMed Central

PMC publication ID

17 October 2017

6242-6256

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions

1 reference

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1 reference

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1 reference

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Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

1 reference

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Relationship between hot spot residues and ligand binding hot spots in protein-protein interfaces

1 reference

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Fragment-based approaches in drug discovery and chemical biology

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Hot spot analysis for driving the development of hits into leads in fragment-based drug discovery

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Emerging role of surface plasmon resonance in fragment-based drug discovery.

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Structural conservation of druggable hot spots in protein-protein interfaces

1 reference

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Introduction to fragment-based drug discovery

1 reference

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Crystal structure of inhibitor of κB kinase β

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"Without Ub I am nothing": NEMO as a multifunctional player in ubiquitin-mediated control of NF-kappaB activation

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APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility.

1 reference

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Protein-protein interactions involving IKKgamma (NEMO) that promote the activation of NF-kappaB.

1 reference

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29 May 2018

The IKK complex, a central regulator of NF-kappaB activation

1 reference

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Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides

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Binding hot spots and amantadine orientation in the influenza a virus M2 proton channel

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The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions

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CHARMM: the biomolecular simulation program

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Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site

1 reference

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High-affinity interaction between IKKbeta and NEMO.

1 reference

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Introduction to NF-kappaB: players, pathways, perspectives

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NEMO binding domain of IKK-2 encompasses amino acids 735-745.

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NF-kB in development and progression of human cancer

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

18 Systematic mutational analyses of protein-protein interfaces

1 reference

https://pubmed.ncbi.nlm.nih.gov/23506214

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA400914Z

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

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