(Q38042773)

English

Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery

scientific article published on 13 September 2012

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

27 August 2017

Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery (English)

1 reference

Europe PubMed Central

27 August 2017

protein structure

0 references

computational biology

1 reference

based on heuristic

inferred from title

protein-protein interaction

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

6

object named as

Tom L Blundell

1 reference

Europe PubMed Central

27 August 2017

Alicia P Higueruelo

2

object named as

Alicia P Higueruelo

1 reference

Europe PubMed Central

27 August 2017

author name string

Anja Winter

1

1 reference

Europe PubMed Central

27 August 2017

May Marsh

3

1 reference

Europe PubMed Central

27 August 2017

Anna Sigurdardottir

4

1 reference

Europe PubMed Central

27 August 2017

Will R Pitt

5

1 reference

Europe PubMed Central

27 August 2017

publication date

13 September 2012

1 reference

Europe PubMed Central

27 August 2017

Quarterly Reviews of Biophysics

1 reference

Europe PubMed Central

27 August 2017

45

1 reference

Europe PubMed Central

27 August 2017

383-426

1 reference

Europe PubMed Central

27 August 2017

4

1 reference

Europe PubMed Central

27 August 2017

From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The overlap of small molecule and protein binding sites within families of protein structures

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Impact of linker strain and flexibility in the design of a fragment-based inhibitor

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment of systemic lupus erythematosus with epratuzumab.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Label-free primary screening and affinity ranking of fragment libraries using parallel analysis of protein panels

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The druggable genome

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

IntAct: an open source molecular interaction database

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

A human phenome-interactome network of protein complexes implicated in genetic disorders

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment-based deconstruction of Bcl-xL inhibitors

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of small-molecule antagonists that inhibit an activator: coactivator interaction

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural biology in fragment-based drug design

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Trapping moving targets with small molecules

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Huntingtin in health and disease

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

PIBASE: a comprehensive database of structurally defined protein interfaces

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

ProtBuD: a database of biological unit structures of protein families and superfamilies.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

SCOPPI: a structural classification of protein-protein interfaces

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of protein-protein interactions using designed molecules

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Inference of macromolecular assemblies from crystalline state

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Discovery of a novel small molecule binding site of human survivin

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Expanding the Genetic Code

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

AutoGrow: a novel algorithm for protein inhibitor design

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Ligand efficiency: a useful metric for lead selection

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

LEA3D: a computer-aided ligand design for structure-based drug design.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

'Double water exclusion': a hypothesis refining the O-ring theory for the hot spots at protein interfaces

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

HIV-1 protease inhibitors: enthalpic versus entropic optimization of the binding affinity.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

MINT: the Molecular INTeraction database

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Assessing the druggability of protein-protein interactions by a supervised machine-learning method

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural characterisation and functional significance of transient protein-protein interactions.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Automated crystal mounting and data collection for protein crystallography

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 reverse transcriptase by fragment library screening.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

A decade of fragment-based drug design: strategic advances and lessons learned

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Enthalpic efficiency of ligand binding

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

DOCKGROUND system of databases for protein recognition studies: unbound structures for docking

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct measurement of protein binding energetics by isothermal titration calorimetry

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

ICBS: a database of interactions between protein chains mediated by beta-sheet formation

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteins.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment-based de novo ligand design by multiobjective evolutionary optimization

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Small-world network approach to identify key residues in protein-protein interaction

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of coupled folding and binding of an intrinsically disordered protein

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein surface recognition and proteomimetics: mimics of protein surface structure and function

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetic studies of small molecule interactions with protein kinases using biosensor technology

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Conformation of glucagon in a lipid-water interphase by 1H nuclear magnetic resonance

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

ANCHOR: a web server and database for analysis of protein-protein interaction binding pockets for drug discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

SNAPPI-DB: a database and API of Structures, iNterfaces and Alignments for Protein-Protein Interactions.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

e-LEA3D: a computational-aided drug design web server

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The binding interface database (BID): a compilation of amino acid hot spots in protein interfaces.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

SkelGen: a general tool for structure-based de novo ligand design.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct inhibition of the NOTCH transcription factor complex

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Enzyme crystal structure in a neat organic solvent

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment-based lead discovery using X-ray crystallography.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Bifunctional recombinant proteins in cancer therapy: cell penetrating peptide aptamers as inhibitors of growth factor signaling

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

DOMINE: a comprehensive collection of known and predicted domain-domain interactions

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Predictions of hot spot residues at protein-protein interfaces using support vector machines.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Study of strong to ultratight protein interactions using differential scanning calorimetry

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Linking folding and binding

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Assessment of helical interfaces in protein-protein interactions

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Predicting protein-protein binding sites in membrane proteins.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Route to three-dimensional fragments using diversity-oriented synthesis

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Experimental validation of a fragment library for lead discovery using SPR biosensor technology

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and characterization of acidic mammalian chitinase inhibitors

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Discovering novel ligands for macromolecules using X-ray crystallographic screening

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

CAVEAT: a program to facilitate the design of organic molecules

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of dynamic conformational ensembles in biomolecular recognition

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

DIMA 3.0: Domain Interaction Map

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

ZINC--a free database of commercially available compounds for virtual screening

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural biology and drug discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Discovery of a novel warhead against beta-secretase through fragment-based lead generation

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Submit your interaction data the IMEx way: a step by step guide to trouble-free deposition

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Anatomy of hot spots in protein interfaces

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

A hot spot of binding energy in a hormone-receptor interface

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The maximal affinity of ligands

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction databases on the same page.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacological strategies for muscular dystrophy

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

DIP: the database of interacting proteins

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Probing the druggability of protein-protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

From knowledge-based potentials to combinatorial lead design in silico

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

In situ assembly of enzyme inhibitors using extended tethering

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Coupling of folding and binding for unstructured proteins

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Experiences in fragment-based lead discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure-based screening of low-affinity compounds

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

An empirical framework for binary interactome mapping

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Hot-spot mimicry of a cytokine receptor by a small molecule

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

An automated microseed matrix-screening method for protein crystallization

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

SCOWLP classification: structural comparison and analysis of protein binding regions.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The SeeDs approach: integrating fragments into drug discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural biology and drug discovery for protein-protein interactions.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

A quantitative model of thermal stabilization and destabilization of proteins by ligands

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Site-directed ligand discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Recent developments in fragment-based drug discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

High-throughput crystallography for lead discovery in drug design.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

On the value of c: can low affinity systems be studied by isothermal titration calorimetry?

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Shape shifting leads to small-molecule allosteric drug discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

A ‘Rule of Three’ for fragment-based lead discovery?

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Measurements of binding thermodynamics in drug discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Homodimeric enzymes as drug targets.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The influence of lead discovery strategies on the properties of drug candidates

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein-protein interactions: organization, cooperativity and mapping in a bottom-up Systems Biology approach.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Druggability indices for protein targets derived from NMR-based screening data

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Understanding and predicting druggability. A high-throughput method for detection of drug binding sites

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Target immobilization as a strategy for NMR-based fragment screening: comparison of TINS, STD, and SPR for fragment hit identification

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The Conformation, Flexibility, and Dynamics of Polypeptide Hormones

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment-based lead discovery: leads by design

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

PRISM: protein interactions by structural matching

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein-protein interactions in receptor activation and intracellular signalling

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Locating and characterizing binding sites on proteins

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Theory and applications of NMR-based screening in pharmaceutical research

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures: physical evidence of a molecular thermometer

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment-based synthesis and SAR of modified FKBP ligands: influence of different linking on binding affinity

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment-based drug design: how big is too big?

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Organic solvents identify specific ligand binding sites on protein surfaces

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Adding new chemistries to the genetic code

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of allosteric PIF-pocket ligands for PDK1 using NMR-based fragment screening and 1H-15N TROSY experiments

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fpocket: an open source platform for ligand pocket detection.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Exact analysis of competition ligand binding by displacement isothermal titration calorimetry.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Screening for GPCR Ligands Using Surface Plasmon Resonance

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

High-density miniaturized thermal shift assays as a general strategy for drug discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular complexity and its impact on the probability of finding leads for drug discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

A simple physical model for binding energy hot spots in protein-protein complexes

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of inhibitors of protein kinase B using fragment-based lead discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

X-ray analysis of glucagon and its relationship to receptor binding

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment screening purely with protein crystallography.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Large-scale comparison of four binding site detection algorithms.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Computer-based de novo design of drug-like molecules

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Features of similarity

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Hormone-receptor interactions: a study of the binding of hormone-substituted tobacco mosaic virus to membrane vesicles by dynamic light scattering and by transient electric bi-refringence

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

PCRPi-DB: a database of computationally annotated hot spots in protein interfaces

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

NMR spectroscopy tools for structure-aided drug design

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

A survey of available tools and web servers for analysis of protein-protein interactions and interfaces

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

New surface contacts formed upon reductive lysine methylation: improving the probability of protein crystallization

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment screening to predict druggability (ligandability) and lead discovery success.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

3did: identification and classification of domain-based interactions of known three-dimensional structure

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Highly accurate method for ligand-binding site prediction in unbound state (apo) protein structures.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

CONFIRM: connecting fragments found in receptor molecules

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

ASEdb: a database of alanine mutations and their effects on the free energy of binding in protein interactions

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Beyond the canonical 20 amino acids: expanding the genetic lexicon

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Isothermal titration calorimetry of protein-protein interactions

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Geometry of nonbonded interactions involving planar groups in proteins

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

PSIbase: a database of Protein Structural Interactome map (PSIMAP).

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

SYNOPSIS: SYNthesize and OPtimize System in Silico

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The RNA aptamer disrupts protein-protein interaction between beta-catenin and nuclear factor-kappaB p50 and regulates the expression of C-reactive protein

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein stability induced by ligand binding correlates with changes in protein flexibility.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment screening of stabilized G-protein-coupled receptors using biophysical methods

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

The Negatome database: a reference set of non-interacting protein pairs

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Anchor residues in protein-protein interactions

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Stabilization of Proteins by Ligand Binding: Application to Drug Screening and Determination of Unfolding Energetics

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Predicting druggable binding sites at the protein-protein interface.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Fragment-based screening using surface plasmon resonance technology

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Practical aspects of NMR-based fragment screening

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

PocketDepth: a new depth based algorithm for identification of ligand binding sites in proteins.

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Higher throughput calorimetry: opportunities, approaches and challenges

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000108

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1017/S0033583512000108

1 reference

Europe PubMed Central

27 August 2017

1 reference

Europe PubMed Central

27 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q38042773&oldid=1803878298"